2892105-43-8
2892105-43-8
Chemical Structure
SARS-CoV-2 nsp3-IN-1
- CAS No.: 2892105-43-8
- Formula:C17H15N5O2
- Molecular Weight:321.33
IUPAC Name: (7H-pyrrolo[2,3-d]pyrimidin-4-yl)-L-tryptophan
InChIKey: NOYXATOHIUTWQW-AWEZNQCLSA-N
SMILES: OC([C@H](CC1=CNC2=C1C=CC=C2)NC3=NC=NC4=C3C=CN4)=O
Biological Activity: SARS-CoV-2 nsp3-IN-1 (Compound 15c) is a Mac1 (SARS-CoV-2 nsp3 macrodomain) inhibitor with the IC50 value of 6.1 μM. SARS-CoV-2 nsp3-IN-1 can inhibit Mac1 ADP-ribosylhydrolase activity. SARS-CoV-2 nsp3-IN-1 demonstrates notable selectivity for coronavirus macrodomains, especially towards SARS-CoV-2 Mac1[1].
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SARS-CoV-2 nsp3-IN-1 | ≥98.0% | SARS-CoV-2 nsp3-IN-1 (Compound 15c) is a Mac1 (SARS-CoV-2 nsp3 macrodomain) inhibitor with the IC50 value of 6.1 μM. SARS-CoV-2 nsp3-IN-1 can inhibit Mac1 ADP-ribosylhydrolase activity. SARS-CoV-2 nsp3-IN-1 demonstrates notable selectivity for coronavirus macrodomains, especially towards SARS-CoV-2 Mac1. | ||||||||||||||||||||
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References
Keywords
