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Results for "

NTS

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Amino Acid Derivatives (1) Apoptosis (1) Biochemical Assay Reagents (2) Histone Demethylase (2) Histone Methyltransferase (1) Liposome (1) Na+/Ca2+ Exchanger (1) Neurotensin Receptor (10) PD-1/PD-L1 (1) Small Interfering RNA (siRNA) (3)
By Research Areas:	Cancer (2) Infection (2) Neurological Disease (11)
Click Chemistry:	Alkynes (1)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Phospholipids (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

Inhibitors & Agonists

Peptides

Inhibitory Antibodies

Recombinant Proteins

Click Chemistry

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-130463

POPG sodium salt PG(16:0/18:1); 1-Palmitoyl-2-oleoyl-sn-glycero-3-phospho-(1'-rac-glycerol)	Liposome Biochemical Assay Reagents Neurotensin Receptor	Neurological Disease
POPG sodium salt is a negatively charged phospholipid. POPG sodium salt affects the interactions of membrane proteins with other molecules by changing the charge characteristics of the lipid environment. POPG sodium salt increases the apparent affinity of Gαq and Gβ₁γ₁ for activated *NTS1*. POPG sodium salt can interact with the positive charge of peptides. POPG sodium salt can be used in Parkinson's disease research .

HY-P10275

*Tat-NTS* peptide**	Apoptosis	Neurological Disease
Tat-NTS peptide is a cell-penetrating peptide with neuroprotective effects. Tat-NTS peptide can specifically inhibit the nuclear translocation of ANXA1 and reduce neuronal apoptosis in ischemic areas. Moreover, Tat-NTS peptide can reduce the volume of cerebral ischemic infarction and can be used in the research of ischemic stroke .

HY-137002

Fmoc-N-Me-Arg(Pbf)-OH	Amino Acid Derivatives Biochemical Assay Reagents	Others
Fmoc-N-Me-Arg(Pbf)-OH is an amino acid derivative containing a guanidinium protecting group on the arginine side chain. Fmoc-N-Me-Arg(Pbf)-OH is used in the synthesis of neurotensin-derived NTS1 ligands for PET imaging .

HY-148650

Sortilin antagonist 1	Neurotensin Receptor	Neurological Disease
Sortilin antagonist 1 (compound 44) is a sortilin antagonist with an IC₅₀ value of 20 nM for inhibiting Neurotensin (NTS) binds to sortilin. Neurotensin is a sortilin ligand. Sortilin antagonist 1 can be used for the research of neurological disease .

HY-P2544

[Lys8, Lys9]-Neurotensin (8-13) JMV438	Neurotensin Receptor	Neurological Disease
[Lys8, Lys9]-Neurotensin (8-13) (JMV438), a Neurotensin analog, exerts its analgesic effects through activation of the G protein-coupled receptors *NTS1* and *NTS2, with K_i* values of 0.33 nM and 0.95 nM for hNTS1 and hNTS2 receptors, respectively .

HY-12436

NTRC-824	Neurotensin Receptor	Neurological Disease
NTRC-824 (Compound 5) is a potent, selective and neurotensin-like nonpeptide neurotensin receptor type 2 (NTS2) antagonist with an IC₅₀ of 38 nM and a K_i of 202 nM. NTRC-824 is >150-fold selectivity for *NTS2* over NTS1 (K_i >30 μM) .

HY-124831

NTRC-844	Neurotensin Receptor	Neurological Disease
NTRC-844 (compound 8) is a selective antagonist of neurotensin receptor type 2 (NTS2),with the EC₅₀ of 238 nM. NTRC-844 plays an important role in analgesic animal research .

HY-137525

NTRC-808	Neurotensin Receptor	Neurological Disease
NTRC-808 is a nonpeptide selective GPCR neurotensin receptor type 2 (NTS2) partial agonist with an EC₅₀ of 14 nM and K_i of 88 nM. NTRC-808 has higher selectivity for NTS2 than for NTS1. NTRC-808 has antipsychotic and analgesic activity .

HY-P991147

Ledostomig	PD-1/PD-L1	Cancer
Ledostomig is an immunoglobulin (H-γ1-scFv-L-κ) dimer monoclonal antibody targeting human netrin-5 (NTS5) and programmed death-1 (PD-1). Ledostomig is promising for research of various cancers .

HY-P10767

MD01-67	Neurotensin Receptor	Neurological Disease
MD01-67 is a selective macrocyclic compound targeting the neurotensin receptor type 2 (NTS2), with K_i of 2.9 nM. MD01-67 exhibits analgesic and tactile hypersensitivity reducing activity in rats acute/persistent/chronic inflammatory pain models .

HY-175184

LSD1-IN-44	Histone Demethylase	Infection
LSD1-IN-44 (Compound 19) is a LSD1 inhibitor with an IC₅₀ of 0.02  μM for LSD1-CoREST enzymatic complex. LSD1-IN-44 has significant antischistosomal activity against transformed schistosomula (NTS) and Schistosoma mansoni adult worms while showing a delayed onset of action towards juvenile forms. LSD1-IN-44 has no significant toxicity to human cells. LSD1-IN-44 can be used for schistosomiasis research .

HY-RS24084

Nts Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Nts Rat Pre-designed siRNA Set A contains three designed siRNAs for Nts gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Nts Rat Pre-designed siRNA Set A Nts Rat Pre-designed siRNA Set A

HY-12217

NTRC-739	Neurotensin Receptor	Neurological Disease
NTRC-739 is a selective nonpeptide partial neurotensin receptor type 2 (NTS2) agonist with an EC₅₀ of 12 nM and a K_i of 153 nM. NTRC-739 is 161-fold selective for NTS2 versus NTS1. NTRC-739 can be used for the study of chronic pain research .

HY-P2025

JMV 236	Histone Methyltransferase	Neurological Disease
JMV 236 is a cholecystokinin antagonist with appetite-suppressing activity. JMV 236 affects the regulation of food intake through the interaction of the intestinal endogenous peptide PrRP and the CCK1 receptor. The administration of JMV 236 activates PrRP neurons located in the NTS, thereby enhancing its appetite-suppressing effect. JMV 236 has significant effects on areas of the central nervous system associated with food intake, especially during states of starvation .

HY-175185

MC3935	Histone Demethylase	Infection
MC3935 is a LSD1 inhibitor with an IC₅₀ of 0.52  μM for LSD1-CoREST enzymatic complex. MC3935 has significant antischistosomal activity against transformed schistosomula (NTS) and Schistosoma mansoni adult worms while showing a delayed onset of action towards juvenile forms. MC3935 has no significant toxicity to human cells. MC3935 can be used for schistosomiasis research .

HY-RS17624

Nts Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Nts Mouse Pre-designed siRNA Set A contains three designed siRNAs for Nts gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Nts Mouse Pre-designed siRNA Set A Nts Mouse Pre-designed siRNA Set A

HY-RS09637

NTS Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
NTS Human Pre-designed siRNA Set A contains three designed siRNAs for NTS gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

NTS Human Pre-designed siRNA Set A NTS Human Pre-designed siRNA Set A

HY-P11594

JMV 7490	Neurotensin Receptor	Cancer
JMV 7490 is a highly potent and highly hydrophilic neurotensin receptor *NTS₁* probe that can be successfully labeled with ⁶⁸Ga and ¹¹¹In. JMV 7490 acts as an efflux inhibitor to reduce its efflux in NTS₁-positive cancer cells; it also serves as an internalization inducer and is efficiently and continuously internalized by NTS₁-positive cancer cells. ¹¹¹In-radiolabeled JMV 7490 shows persistent uptake in NTS₁-positive xenografts in nude mice, but no significant uptake in NTS₁-negative xenografts. JMV 7490 can be used for in vivo tracer applications of NTS1-positive tumors and supports related research on colorectal cancer .

HY-W574030

Fmoc-DL-Leu-OH	Neurotensin Receptor	Neurological Disease
Fmoc-DL-Leu-OH acts as a partial agonist of the neurotensin NTS1 receptor (NTS1R) with an EC₅₀ of 215.50 μM. Fmoc-DL-Leu-OH triggers intracellular calcium mobilization, and its activity is blocked by selective NTS1R antagonists. Fmoc-DL-Leu-OH can be used in the research of schizophrenia .

HY-132227

Dichlorobenzamil hydrochloride 3',4'-Dichlorobenzamil hydrochloride; L-594881 hydrochloride	Na+/Ca2+ Exchanger	Others
Dichlorobenzamil (3',4'-Dichlorobenzamil; L-594881) hydrochloride is a Na ⁺-Ca ²⁺ Exchanger inhibitor. Dichlorobenzamil (hydrochloride) attenuates the Na ⁺-Ca ²⁺ exchanger-mediated inward current induced by activation of type I metabotropic glutamate receptors in second-order baroreceptor neurons of the rat nucleus tractus solitarius .

Cat. No.	Product Name	Target	Research Area