1811503-67-9
1811503-67-9
Chemical Structure
NTRC-844
- CAS No.: 1811503-67-9
- Formula:C28H28FN3O4
- Molecular Weight:489.54
IUPAC Name: (1R,3S,5r,7r)-2-(1-(4-fluorophenyl)-5-(2-methoxyphenyl)-1H-pyrazole-3-carboxamido)adamantane-2-carboxylic acid
InChIKey: CFHHPKGFMMIMOJ-BRZMSGEPSA-N
SMILES: O=C(C1=NN(C(C=C2)=CC=C2F)C(C(C=CC=C3)=C3OC)=C1)NC4([C@H]5C[C@H](C6)C[C@@H]4C[C@H]6C5)C(O)=O
Biological Activity: NTRC-844 (compound 8) is a selective antagonist of neurotensin receptor type 2 (NTS2),with the EC50 of 238 nM. NTRC-844 plays an important role in analgesic animal research[1].
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NTRC-844 | 95.60% | NTRC-844 (compound 8) is a selective antagonist of neurotensin receptor type 2 (NTS2),with the EC50 of 238 nM. NTRC-844 plays an important role in analgesic animal research. | ||||||||||||||||||||
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References
- [1]. James B Thomas, et al. Identification of 2-({[1-(4-Fluorophenyl)-5-(2-methoxyphenyl)-1H-pyrazol-3-yl]carbonyl}amino)tricyclo[3.3.1.13,7]decane-2-carboxylic Acid (NTRC-844) as a Selective Antagonist for the Rat Neurotensin Receptor Type 2. ACS Chem Neurosci. 2016 Sep 21;7(9):1225-31. [Content Brief]
Keywords
