2. GPCR/G Protein Neuronal Signaling
  3. Neurotensin Receptor
  4. NTRC-739

NTRC-739 is a selective nonpeptide partial neurotensin receptor type 2 (NTS2) agonist with an EC50 of 12 nM and a Ki of 153 nM. NTRC-739 is 161-fold selective for NTS2 versus NTS1. NTRC-739 can be used for the study of chronic pain research.

For research use only. We do not sell to patients.

NTRC-739

NTRC-739 Chemical Structure

CAS No. : 1612188-96-1

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NTRC-739 Related Antibodies

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Description

NTRC-739 is a selective nonpeptide partial neurotensin receptor type 2 (NTS2) agonist with an EC50 of 12 nM and a Ki of 153 nM. NTRC-739 is 161-fold selective for NTS2 versus NTS1. NTRC-739 can be used for the study of chronic pain research[1].

IC50 & Target[1]

NTR2

12 nM (EC50)

NTR2

153 nM (Ki)

Cellular Effect
Cell Line Type Value Description References
CHO-K1 EC50
12 nM
Compound: 7b
Partial agonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assay
Partial agonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assay
[PMID: 24856674]
CHO-K1 EC50
7 nM
Compound: 7b
Partial agonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assay relative to SR142948a
Partial agonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as induction of calcium release by FLIPR assay relative to SR142948a
[PMID: 24856674]
CHO-K1 IC50
153 nM
Compound: 7b
Antagonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as inhibition of SR142948a-induced calcium release by FLIPR assay
Antagonist activity at rat NTS2 stably expressed in CHOK1 cells assessed as inhibition of SR142948a-induced calcium release by FLIPR assay
[PMID: 24856674]
Molecular Weight

437.46

Formula

C24H24FN3O4
CAS No.
SMILES

O=C(C1(NC(C2=NN(C3=CC=C(F)C=C3)C(C4=CC=CC=C4OC)=C2)=O)CCCCC1)O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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NTRC-739 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NTRC-7391612188-96-1NTRC739NTRC 739Neurotensin ReceptorNTS2 Agonistchronic painanalgesiaInhibitorinhibitorinhibit

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