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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
24 Results for "
PAD1
" in MedChemExpress (MCE) Product Catalog:
Products (24)
24 Results for "PAD1" in MCE Product Catalog:
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24 Publications Verification
Research Areas:
Cl-amidine hydrochloride is an orally active peptidylarginine deminase (PAD) inhibitor, with IC50 values of 0.8 μM, 6.2 μM and 5.9 μM for PAD1, PAD3, and PAD4, respectively. Cl-amidine hydrochloride induces apoptosis in cancer cells. Cl-amidine hydrochloride induces microRNA (miR)-16 (miRNA-16, microRNA-16) expression and causes cell cycle arrest. Cl-Amidine hydrochloride prevents histone 3 citrullination and neutrophil extracellular trap formation, and improves survival in a murine sepsis model [1] .
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24 Publications Verification
Cat. No.: HY-100574B
CAS No.: 1043444-18-3
Research Areas:
Cl-amidine TFA is an orally active peptidylarginine deminase (PAD) inhibitor, with IC50 values of 0.8 μM, 6.2 μM and 5.9 μM for PAD1, PAD3, and PAD4, respectively. Cl-amidine TFA induces apoptosis in cancer cells. Cl-amidine TFA induces microRNA (miR)-16 (miRNA-16, microRNA-16) expression and causes cell cycle arrest. Cl-Amidine TFA prevents histone 3 citrullination and neutrophil extracellular trap formation, and improves survival in a murine sepsis model [1] .
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Cat. No.: HY-P790098
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: PSMD14; 26S Proteasome Regulatory Subunit RPN11; Proteasome 26S Subunit, Non-ATPase 14; Ubiquitin C-Terminal Hydrolase PSMD14; POH1; Testis Tissue Sperm-Binding Protein Li 69n; 26S Proteasome Non-ATPase Regulatory Subunit 14; 26S Proteasome Regulatory Sub
Cat. No.: HY-176710
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PAD-PF2 is a PAD family inhibitor, as well as a κ-opioid receptor agonist (EC50 = 7.55 μM) and an M1 muscarinic acetylcholine receptor antagonist (IC50 = 12.3 μM). The IC50 values of PAD-PF2 against PAD1, PAD2, PAD3 and PAD4 are 109 nM, 27.9 nM, 106 nM and 20.1 nM, respectively. PAD-PF2 binds to the common allosteric pocket of PAD1-4, and its inhibitory effects on PAD2 and PAD4 are Ca 2+-dependent. PAD-PF2 inhibits protein citrullination in neutrophils. PAD-PF2 is applicable to research related to rheumatoid arthritis, neurodegenerative diseases and cancer [1].
Cat. No.: HY-100574
CAS No.: 913723-61-2
Research Areas:
Cl-amidine is an orally active peptidylarginine deminase (PAD) inhibitor, with IC50 values of 0.8 μM, 6.2 μM and 5.9 μM for PAD1, PAD3, and PAD4, respectively. Cl-amidine induces apoptosis in cancer cells. Cl-amidine induces microRNA (miR)-16 (miRNA-16, microRNA-16) expression and causes cell cycle arrest. Cl-Amidine prevents histone 3 citrullination and neutrophil extracellular trap formation, and improves survival in a murine sepsis model [1] .
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BMS-P5 is a selective and orally active peptidylarginine deiminase 4 (PAD4) inhibitor with an IC50 of 98 nM. BMS-P5 shows selective for PAD4 over PAD1, PAD2, and PAD3. BMS-P5 blocks multiple myeloma (MM)-induced neutrophil extracellular trap (NET) formation and delays progression of MM in a syngeneic mouse model [1].
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BMS-P5 free base is a selective and orally active peptidylarginine deiminase 4 (PAD4) inhibitor with an IC50 of 98 nM. BMS-P5 free base shows selective for PAD4 over PAD1, PAD2, and PAD3. BMS-P5 free base blocks multiple myeloma (MM)-induced neutrophil extracellular trap (NET) formation and delays progression of MM in a syngeneic mouse model [1].
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D-Cl-amidine hydrochloride is a potent and highly selective PAD1 inhibitor. D-Cl-amidine is well-torelated with no significant toxicity [1].
Cat. No.: HY-122365R
CAS No.: 6556-11-2
Synonyms: Inositol niacinate (Standard); Hexanicit (Standard)
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Inositol nicotinate (Standard) is the analytical standard of Inositol nicotinate. This product is intended for research and analytical applications. Inositol nicotinate, with vasodilatory effect, is used in the study of Peripheral arterial disease (PAD) .
Cat. No.: HY-174349
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PAD-IN-3 (Compound 16) is a potent dual peptidyl arginine deiminases 4 (PAD4) and PAD1 inhibitor with IC50 values of 0.204 μM and 0.273 μM, respectively. PAD-IN-3 is promising for research of citrullination-associated disorders such as cancer and autoimmune diseases [1].
Cat. No.: HY-100574C
CAS No.: 1404060-15-6
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D-Cl-amidine is a potent and highly selective PAD1 inhibitor. D-Cl-amidine is well-torelated with no significant toxicity [1].
Cat. No.: HY-137124
CAS No.: 2219331-30-1
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BB-F-Yne is a protein arginine deiminase (PAD) inhibitor with Ki values of PAD1-4.are 2050, 1700, 1100, 3100 M -1min -1 respectively. BB-F-Yne can be used as a click probe to label PAD .
Cat. No.: HY-137125
CAS No.: 2219324-71-5
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BB-Cl-Yne is a protein arginine deiminase (PAD) inhibitor with Ki values of PAD1-4.are 6400, 3600, 10800, 4900 M -1min -1 respectively. BB-Cl-Yne can be used as a click probe to label PAD .
Cat. No.: HY-139088
CAS No.: 1671088-84-8
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PAD3-IN-1 (compound 14b) is an inhibitor of protein arginine deiminase (PAD) and is more than 10-fold more selective for PAD3 than PAD 1, 2, and 4. The IC50 values of PAD3-IN-1 for PAD 1, 2, 3, and 4 are 120, 27.5, 4.5, and 30.5 μM, respectively. And PAD3 is a PAD isoform associated with neurodegenerative responses to spinal cord injury, and PAD3-IN-1 could be used to study PAD-related neurological diseases [1].
Cat. No.: HY-178365
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PAD-IN-4 is a potent PAD inhibitor (PAD 1/4, IC50 = 0.273/0.24 μM). PAD-IN-4 shows no significant cytotoxicity against A549 or MDA-MB-231 cells. PAD-IN-4 can be used for the study of cancer and autoimmune diseases [1].
Cat. No.: HY-P703022
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: PADI1; PDI; Peptidyl Arginine Deiminase 1; Peptidyl Arginine Deiminase, Type I; PDI1; Protein-Arginine Deiminase Type I; PAD1; Peptidylarginine Deiminase I; Protein-Arginine Deiminase Type-1; HPAD-Colony 10; HPAD10; Peptidylarginine Deiminase Type I
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Cat. No.: HY-P704834
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: PADI1; PDI; Peptidyl Arginine Deiminase 1; Peptidyl Arginine Deiminase, Type I; PDI1; Protein-Arginine Deiminase Type I; PAD1; Peptidylarginine Deiminase I; Protein-Arginine Deiminase Type-1; HPAD-Colony 10; HPAD10; Peptidylarginine Deiminase Type I
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Cat. No.: HY-100574DR
CAS No.: 2985338-61-0
Research Areas:
D-Cl-amidine (hydrochloride) (Standard) is the analytical standard of D-Cl-amidine (hydrochloride) (HY-100574D). This product is intended for research and analytical applications. D-Cl-amidine hydrochloride is a potent and highly selective PAD1 inhibitor. D-Cl-amidine is well-torelated with no significant toxicity [1].
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
