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Isoforms Recommended:	Protein Polybromo-1

Results for "

PBRM1

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (1) Epigenetic Reader Domain (14) Ligands for Target Protein for PROTAC (1) Molecular Glues (1) PROTACs (3) Small Interfering RNA (siRNA) (3) SWI/SNF Complex (3)
By Research Areas:	Cancer (16)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

Inhibitors & Agonists

Antibodies

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-128359

ACBI1 10+ Cited Publications	PROTACs SWI/SNF Complex Apoptosis	Cancer
ACBI1 is a potent and cooperative SMARCA2, SMARCA4 and *PBRM1* degrader with DC₅₀s of 6, 11 and 32 nM, respectively. ACBI1 is a PROTAC degrader. ACBI1 shows anti-proliferative activity. ACBI1 induces apoptosis ^[1].

HY-163410

AU-24118 1 Publications Verification	PROTACs Epigenetic Reader Domain	Cancer
AU-24118 is a selective and orally bioavailable PROTAC degrader of mSWI-SNF ATPases (SMARCA2 and SMARCA4) and *PBRM1. AU-24118 integrates a bait moiety binding to the bromodomains of SMARCA2 and SMARCA4, along with a ligand moiety for CRBN ligase. AU-24118 demonstrates tumor regression in prostate cancer model. AU-24118 can be studied to combat prostate cancer. (Pink: PBRM1/SMARCA2,4* ligand (HY-171774); Blue: CRBN ligand (HY-171775)) ^[1].

HY-151538

PBRM1-BD2-IN-8	Epigenetic Reader Domain	Cancer
PBRM1-BD2-IN-8 (compound 34) is a potent PBRM1 Bromodomain inhibitor (PBRM1-BD2 K_d=4.4 μM, PBRM1-BD2 IC₅₀=0.16 μM; PBRM1-BD5 K_d=25 μM). PBRM1-BD2-IN-8 shows anti-cancer activity ^[1].

HY-151532

PBRM1-BD2-IN-5	Epigenetic Reader Domain	Cancer
PBRM1-BD2-IN-5 is a potent PBRM1 Bromodomain inhibitor with K_d values of 1.5 μM and 3.9 μM for PBRM1-BD2 and PBRM1-BD5, respectively, and an IC₅₀ value of 0.26 μM for PBRM1-BD2. PBRM1-BD2-IN-5 reduces the binding of full-length PBRM1 within the PBAF complex in cell lysates to acetylated histone peptide. PBRM1-BD2-IN-5 can be used to research anticancer ^[1].

HY-149026

GNE-064	Epigenetic Reader Domain	Others
GNE-064 (compound 5) is a selective, orally active and highly soluble inhibitor of SMARCA4, SMARCA2 and *PBRM1* bromodomains 5. GNE-064 inhibits SMARCA4 with an IC₅₀ of 0.035 μM and inhibits SMARCA2 with an EC₅₀ of 0.10 μM. GNE-064 possess K_ds with 0.01, 0.016, 0.018 and 0.049 μM for SMARCA4, SMARCA2, PBRM1 bromodomains 5 and PBRM1 bromodomains 2, repectively. GNE-064 can be used as a chemical probe for the research of agent synthesis ^[1].

HY-150289

GNE-235	Epigenetic Reader Domain	Cancer
GNE-235 is a compound selective for the second bromodomain of *PBRM1, with a K_D* of 0.28 ± 0.02 μM. GNE-235 can be used for evaluation of the cellular function of PBRM1 ^[1].

HY-151531

PBRM1-BD2-IN-4	Epigenetic Reader Domain	Cancer
PBRM1-BD2-IN-4 (compound 15) is a potent PBRM1 Bromodomain inhibitor with K_d values of 5.5 μM and 11.1 μM for PBRM1-BD2 and PBRM1-BD5, respectively, and an IC₅₀ value of 0.2 μM for PBRM1-BD2. PBRM1-BD2-IN-4 can be used to research anticancer ^[1].

HY-151528

PBRM1-BD2-IN-1	Epigenetic Reader Domain	Cancer
PBRM1-BD2-IN-1 is a selective and cell-active polybromo-1 (PBRM1) bromodomain inhibitor. PBRM1-BD2-IN-1 has binding affinity and inhibitory activity for PBRM1-BD2 with K_d and IC₅₀ values of 0.7 μM and 0.2 μM, respectively. PBRM1-BD2-IN-1 can be used for the research of cancer ^[1].

HY-RS10105

PBRM1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
PBRM1 Human Pre-designed siRNA Set A contains three designed siRNAs for PBRM1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

PBRM1 Human Pre-designed siRNA Set A PBRM1 Human Pre-designed siRNA Set A

HY-175756

SMARCA2/4 degrader-1	Molecular Glues SWI/SNF Complex	Cancer
SMARCA2/4 degrader-1 is a SMARCA2/4 molecular glue degrader with a DCAF16 EC₅₀ of 110 nM. SMARCA2/4 degrader-1 covalently adducts at cysteine to form a ternary complex with SMARCA2/4 and recruits CUL4 ^DCAF16 and CRL1 ^FBXO22 E3 ligase complexes. SMARCA2/4 degrader-1 induces ubiquitination and proteasomal degradation of SMARCA2/4. SMARCA2/4 degrader-1 can be used for research of SMARCA4-deficient malignancies, non-small cell lung cancer (NSCLC), and colorectal cancer ^[1].

HY-151533

PBRM1-BD2-IN-6	Epigenetic Reader Domain	Cancer
PBRM1-BD2-IN-6 is a potent PBRM1 bromodomain inhibitor with an IC₅₀ value of 0.22 μM. PBRM1-BD2-IN-6 shows antiproliferation activity. PBRM1-BD2-IN-6 has the potential for the research of PBRM1-dependent cancer ^[1].

HY-151529

PBRM1-BD2-IN-2	Epigenetic Reader Domain	Cancer
PBRM1-BD2-IN-2 is a selective and cell-active polybromo-1 (PBRM1) bromodomain inhibitor. PBRM1-BD2-IN-2 has binding affinity and inhibitory activity for PBRM1-BD2 with K_d and IC₅₀ values of 9.3 μM and 1.0 μM, respectively. PBRM1-BD2-IN-2 can be used for the research of cancer ^[1].

HY-171774

PBRM1/SMARCA2,4-ligand-1	Ligands for Target Protein for PROTAC Epigenetic Reader Domain	Cancer
PBRM1/SMARCA2,4-ligand-1 (Compound 4) is a Ligand for Target Protein for PROTAC that binds to *PBRM1, SMARCA2, and SMARCA4. PBRM1/SMARCA2,4-ligand-1* is a potent SMARCA4 bromodomain inhibitor. PBRM1/SMARCA2,4-ligand-1 can be used to synthesize PROTAC AU-24118 (HY-163410) ^[1] .

HY-151530

PBRM1-BD2-IN-3	Epigenetic Reader Domain	Cancer
PBRM1-BD2-IN-3 (compound 12) is a potent *PBRM1-BD2* inhibitor with an IC₅₀ value of 1.1 μM. PBRM1-BD2 Inhibitor can be used to research anticancer ^[1].

HY-174237

PBRM1/SMARCA2,4 binder-1	Epigenetic Reader Domain	Cancer
PBRM1/SMARCA2,4 binder-1 (Compound 17) is a binder of *PBRM1, SMARCA2, and SMARCA4* (IC₅₀: 0.083, 0.153, and 0.046 μM, respectively) ^[1].

HY-RS24387

Pbrm1 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Pbrm1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Pbrm1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Pbrm1 Rat Pre-designed siRNA Set A Pbrm1 Rat Pre-designed siRNA Set A

HY-RS17918

Pbrm1 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Pbrm1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Pbrm1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Pbrm1 Mouse Pre-designed siRNA Set A Pbrm1 Mouse Pre-designed siRNA Set A

HY-151534

PBRM1-BD2-IN-7	Epigenetic Reader Domain	Cancer
PBRM1-BD2-IN-7 is a selective and cell-active polybromo-1 (PBRM1) bromodomain inhibitor. PBRM1-BD2-IN-7 has inhibitory activity for PBRM1-BD2 with an IC₅₀ value of 0.29 μM. PBRM1-BD2-IN-7 can be used for the research of cancer ^[1].

HY-161881

SMARCA2-IN-9	Epigenetic Reader Domain	Cancer
SMARCA2-IN-9 (compound 11) is a SMARCA2, **PBRM1 bromodomains 2 (PBRM1(2)), and PBRM1 bromodomains 5 (PBRM1(5)) inhibitor with K_d** values of 1.6 μM, 2.5 μM, and 3.95 μM, respectively ^[1].

HY-183007

LJM133	PROTACs SWI/SNF Complex	Cancer
LJM133 is a *SMARCA2/PBRM1/SMARCA4* PROTAC degrader with DC₅₀ values of 3.5 nM, 7 nM, and 6.4 nM. LJM133 induces ternary complex formation with VHL E3 ligase to drive proteasome-mediated degradation of target proteins. LJM133 suppresses cell proliferation and exhibits significant antitumor efficacy in a SMARCA4 mutant cancer xenograft model. LJM133 can be used for the research of cancer, such as SMARCA4 mutant non-small cell lung cancer ^[1]. (Pink: SMARCA2/PBRM1/SMARCA4 ligand (HY-182987); E3 ubiquitin ligase ligand-linker conjugate (HY-183619)).

Host:	Rabbit (2)
Reactivity:	Human (2)
Application:	IHC-P (2)
Isotype:	IgG (2)
Conjugation:	Non-conjugated (2)
Clonality:	Monoclonal (1) Recombinant (1)
Modification:	Unmodified (1)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P81431

	Baf180 Antibody (YA1176) BAF180; hPB1; PB1; PBRM1; polybromo 1; Polybromo-1D	IHC-P	Human
	Baf180 Antibody (YA1176) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Baf180.

HY-P81431A

	Baf180 Antibody (YA1176)(PBS only) BAF180; hPB1; PB1; PBRM1; polybromo 1; Polybromo-1D	IHC-P	Human
	Baf180 Antibody (YA1176) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Baf180.

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PBRM1 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
PBRM1 Human Pre-designed siRNA Set A contains three designed siRNAs for PBRM1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

Pbrm1 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Pbrm1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Pbrm1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Pbrm1 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Pbrm1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Pbrm1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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