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Cat. No.: HY-151530

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PBRM1-BD2-IN-3

PBRM1-BD2-IN-3 (compound 12) is a potent PBRM1-BD2 inhibitor with an IC₅₀ value of 1.1 μM. PBRM1-BD2 Inhibitor can be used to research anticancer.

For research use only. We do not sell to patients.

CAS No.: 2819989-58-5
Formula: C₁₄H₁₁ClN₂O
Molecular Weight:258.70

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

PBRM1-BD2-IN-3 Chemical Structure

CAS No.: 2819989-58-5

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

PBRM1-BD2-IN-3 (compound 12) is a potent PBRM1-BD2 inhibitor with an IC₅₀ value of 1.1 μM. PBRM1-BD2 Inhibitor can be used to research anticancer^[1].

IC₅₀ & Target

IC₅₀: 1.1 μM (PBRM1-BD2)^[1]

All Epigenetic Reader Domain Isoforms :

All SWI/SNF Complex Isoforms :

Chemical Information

CAS No. 2819989-58-5
Molecular Weight 258.70
Formula C₁₄H₁₁ClN₂O
SMILES

O=C1NC(C2=CC=CC=C2)NC3=C1C(Cl)=CC=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Shishodia S, et al. Selective and Cell-Active PBRM1 Bromodomain Inhibitors Discovered through NMR Fragment Screening. J Med Chem. 2022 Oct 13. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References

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PBRM1-BD2-IN-3

All Epigenetic Reader Domain Isoforms

All SWI/SNF Complex Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

PBRM1-BD2-IN-3 Related Classifications

HY-151530 Related Classifications