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Cat. No.: HY-151533

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PBRM1-BD2-IN-6

PBRM1-BD2-IN-6 is a potent PBRM1 bromodomain inhibitor with an IC₅₀ value of 0.22 μM. PBRM1-BD2-IN-6 shows antiproliferation activity. PBRM1-BD2-IN-6 has the potential for the research of PBRM1-dependent cancer.

For research use only. We do not sell to patients.

CAS No.: 2819989-67-6
Formula: C₁₆H₁₅ClN₂O
Molecular Weight:286.76

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

PBRM1-BD2-IN-6 Chemical Structure

CAS No.: 2819989-67-6

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

IC₅₀: 0.22 nM (PBRM1-BD2)^[1]

All Epigenetic Reader Domain Isoforms :

All SWI/SNF Complex Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
LNCaP	IC₅₀	0.66 μM Compound: 25	Cytotoxicity against human LNCaP cells assessed as inhibition of cell growth measured after 7 days with compound replacement for every 48 hrs by celltiter-glo assay Cytotoxicity against human LNCaP cells assessed as inhibition of cell growth measured after 7 days with compound replacement for every 48 hrs by celltiter-glo assay	[PMID: 36227159]

In Vitro

PBRM1-BD2-IN-6 (compound 25) (0.1, 1, 10 μM; 5 days) shows antiproliferation activity with IC₅₀ values of 0.66, 0.77, 0.32 μM for LNCaP, PC3, HEK293T cells, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:

LNCaP, PC3, HEK293T cells
Concentration:

0.1, 1, 10 μM
Incubation Time:

5 days
Result:

Inhibited the cell growth with IC₅₀ values of 0.66, 0.77, 0.32 µM for LNCaP, PC3, HEK293T cells, respectively.

Chemical Information

CAS No. 2819989-67-6
Molecular Weight 286.76
Formula C₁₆H₁₅ClN₂O
SMILES

O=C1NC(C2=CC=CC(C)=C2C)NC3=C1C(Cl)=CC=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Shishodia S, et al. Selective and Cell-Active PBRM1 Bromodomain Inhibitors Discovered through NMR Fragment Screening. J Med Chem. 2022 Oct 13. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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PBRM1-BD2-IN-6

All Epigenetic Reader Domain Isoforms

All SWI/SNF Complex Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

PBRM1-BD2-IN-6 Related Classifications

HY-151533 Related Classifications