PBRM1-BD2-IN-6
PBRM1-BD2-IN-6 is a potent PBRM1 bromodomain inhibitor with an IC50 value of 0.22 μM. PBRM1-BD2-IN-6 shows antiproliferation activity. PBRM1-BD2-IN-6 has the potential for the research of PBRM1-dependent cancer.
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- CAS. Nr.: 2819989-67-6
- Formel: C16H15ClN2O
- Molecular Weight:286.76
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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- Reinheit & Dokumentation
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Help & FAQs
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Biologische Aktivität
Beschreibung
IC50 & Target
IC50: 0.22 nM (PBRM1-BD2)[1]
Cellular Effect
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Cell Line
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Type | Value | Description | References |
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| LNCaP | IC50 |
0.66 μM
Compound: 25
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Cytotoxicity against human LNCaP cells assessed as inhibition of cell growth measured after 7 days with compound replacement for every 48 hrs by celltiter-glo assay
Cytotoxicity against human LNCaP cells assessed as inhibition of cell growth measured after 7 days with compound replacement for every 48 hrs by celltiter-glo assay
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[PMID: 36227159] |
In Vitro
PBRM1-BD2-IN-6 (compound 25) (0.1, 1, 10 μM; 5 days) shows antiproliferation activity with IC50 values of 0.66, 0.77, 0.32 μM for LNCaP, PC3, HEK293T cells, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
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Cell Line:LNCaP, PC3, HEK293T cells
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Concentration:0.1, 1, 10 μM
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Incubation Time:5 days
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Result:Inhibited the cell growth with IC50 values of 0.66, 0.77, 0.32 µM for LNCaP, PC3, HEK293T cells, respectively.
Chemical Information
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CAS. Nr. 2819989-67-6
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Molecular Weight 286.76
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Formel C16H15ClN2O
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SMILES
O=C1NC(C2=CC=CC(C)=C2C)NC3=C1C(Cl)=CC=C3
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Protokoll
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
PBRM1-BD2-IN-6 Related Classifications
HY-151533 Related Classifications
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