2819989-61-0
2819989-61-0
Chemical Structure
PBRM1-BD2-IN-5
- CAS No.: 2819989-61-0
- Formula:C15H13ClN2O
- Molecular Weight:272.73
IUPAC Name: 5-chloro-2-(2,3-dimethylphenyl)-2,3-dihydroquinazolin-4(1H)-one
InChIKey: OBDBCXGMLSMARG-UHFFFAOYSA-N
SMILES: O=C1NC(C2=CC=CC(C)=C2)NC3=C1C(Cl)=CC=C3
Biological Activity: PBRM1-BD2-IN-5 is a potent PBRM1 Bromodomain inhibitor with Kd values of 1.5 μM and 3.9 μM for PBRM1-BD2 and PBRM1-BD5, respectively, and an IC50 value of 0.26 μM for PBRM1-BD2. PBRM1-BD2-IN-5 reduces the binding of full-length PBRM1 within the PBAF complex in cell lysates to acetylated histone peptide. PBRM1-BD2-IN-5 can be used to research anticancer[1].
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PBRM1-BD2-IN-5 | 99.75% | PBRM1-BD2-IN-5 is a potent PBRM1 Bromodomain inhibitor with Kd values of 1.5 μM and 3.9 μM for PBRM1-BD2 and PBRM1-BD5, respectively, and an IC50 value of 0.26 μM for PBRM1-BD2. PBRM1-BD2-IN-5 reduces the binding of full-length PBRM1 within the PBAF complex in cell lysates to acetylated histone peptide. PBRM1-BD2-IN-5 can be used to research anticancer. | ||||||||||||||||||||
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