PBRM1-BD2-IN-4
PBRM1-BD2-IN-4 is a PBRM1-BD2 inhibitor with an IC50 of 0.2 μM, and its Kd values for PBRM1-BD2 and PBRM1-BD5 are 5.5 μM and 11.1 μM, respectively. PBRM1-BD2-IN-4 selectively inhibits the proliferation of PBRM1-dependent prostate cancer cells. PBRM1-BD2-IN-4 can be used in studies related to prostate cancer.
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- CAS. Nr.: 2819989-60-9
- Formel: C15H13ClN2O
- Molecular Weight:272.73
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
Beschreibung
IC50 & Target
[1]|
BD2 0.2 μM (IC50) |
In Vitro
PBRM1-BD2-IN-4 (Compound 12) (0.1-10 μM; 5 days) inhibits the proliferation of LNCaP cells in a dose-dependent manner, while exerts no significant effect on PC3 and PWPE-1 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:LNCaP, PC3 and PWPE-1 cell
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Concentration:0.1, 1 and 10 μM
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Incubation Time:5 days
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Result:Inhibited the proliferation of LNCaP cells in a dose-dependent manner, while exerts no significant effect on PC3 and PWPE-1 cells.
Chemical Information
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CAS. Nr. 2819989-60-9
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Molecular Weight 272.73
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Formel C15H13ClN2O
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SMILES
O=C1NC(C2=CC=CC=C2C)NC3=C1C(Cl)=CC=C3
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
PBRM1-BD2-IN-4 Related Classifications
HY-151531 Related Classifications
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