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PI(4

" in MedChemExpress (MCE) Product Catalog:

72

Inhibitors & Agonists

2

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1

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3

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4

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4

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2

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20

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Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-12016
    KU-55933
    Maximum Cited Publications
    62 Publications Verification

    ATM/ATR Autophagy Cancer
    KU-55933 is a potent ATM inhibitor with an IC50 and Ki of 12.9 and 2.2 nM, respectively, and is highly selective for ATM as compared to DNA-PK, PI3K/PI4K, ATR and mTOR.
    KU-55933
  • HY-103489
    PI-273
    5+ Cited Publications

    PI4K Apoptosis Cancer
    PI-273 is a first reversibly and specific phosphatidylinositol 4-kinase (PI4KIIα) inhibitor with an IC50 of 0.47 μM. PI-273 can inhibit breast cancer cell proliferation, block the cell cycle and induce cell apoptosis .
    PI-273
  • HY-125118
    GSK-A1
    2 Publications Verification

    PI4K HCV Infection
    GSK-A1 is a selective type III phosphatidylinositol 4-kinase PI4KA (PI4KIIIα) inhibitor with a pIC50 of 8.5-9.8. GSK-A1 inhibits PtdIns(4,5)P2 resynthesis with an IC50 of about 3 nM. GSK-A1 potently decreases the levels of PtdIns(4)P with a negligible effect on PtdIns(4,5)P2. GSK-A1 has the potential for anti-hepatitis C virus (HCV) research .
    GSK-A1
  • HY-12046
    PIK-93
    5+ Cited Publications

    PI4K PI3K Virus Protease Cancer
    PIK-93 is the first potent, synthetic PI4K (PI4KIIIβ) inhibitor with IC50 of 19 nM, and also inhibits PI3Kγ and PI3Kα with IC50 of 16 nM and 39 nM, respectively.
    PIK-93
  • HY-106005
    MMV390048
    3 Publications Verification

    Parasite PI4K Infection
    MMV390048 is a representative of a new chemical class of Plasmodium PI4K inhibitor (Kd app=0.3 µM). MMV390048 binds to the ATP binding site of Plasmodium PI4K and does not bind to other P. falciparum and human kinases apart from human PIP4K2C, thus alleviating potential kinase-mediated safety concerns. MMV390048 is an antimalarial agent .
    MMV390048
  • HY-100198
    PI4KIIIbeta-IN-10
    10+ Cited Publications

    PI4K PI3K Infection
    PI4KIIIbeta-IN-10 is a potent PI4KIIIβ inhibitor with an IC50 of 3.6 nM.
    PI4KIIIbeta-IN-10
  • HY-115675

    PI4K Others
    NC03 is a PI4K2A inhibitor and reducing agent. NC03 inhibits the activity of PI4K2A, thereby reducing the production of PI4P in the cellular compartments where PI4K2A functions. NC03 rapidly induces a decrease in PI4P pools in the Golgi and endosomal compartments. NC03 reduces PI4P production in Rab7-positive late endosomes .
    NC03
  • HY-U00426
    BF738735
    5 Publications Verification

    PI4K Reverse Transcriptase Infection
    BF738735 is a phosphatidylinositol 4-kinase III beta (PI4KIIIβ) inhibitor with an IC50 of 5.7 nM.
    BF738735
  • HY-108313
    T-00127_HEV1
    4 Publications Verification

    PI4K Infection
    T-00127_HEV1 is a phosphatidylinositol 4-kinase III beta (PI4KB) inhibitor with an IC50 of 60 nM.
    T-00127_HEV1
  • HY-12912

    PI4K Parasite Infection
    KDU691, an imidazopyrazine with potent anti-parasitic activity against blood stage schizonts, gametocytes and liver stages, is a Plasmodium PI4K inhibitor. KDU691 selectively inhibits dihydroartemisinin-pretreated Plasmodium falciparum ring-stage parasites .
    KDU691
  • HY-112613
    UCB9608
    1 Publications Verification

    PI4K Inflammation/Immunology
    UCB9608 is a potent, selective and orally active PI4KIIIβ inhibitor, with an IC50 of 11 nM, selective over PI3KC2 α, β, and γ lipid kinases. UCB9608 improves metabolic stability and exhibits excellent pharmacokinetic profile, acts as a potent immunosuppressive agent .
    UCB9608
  • HY-19798
    PI4KIIIbeta-IN-9
    5 Publications Verification

    PI4K PI3K Cancer
    PI4KIIIbeta-IN-9 is a potent PI4KIIIβ inhibitor with an IC50 of 7 nM. PI4KIIIbeta-IN-9 also inhibits PI3Kδ and PI3Kγ with IC50s of 152 nM and 1046 nM, respectively.
    PI4KIIIbeta-IN-9
  • HY-15679
    PI4KIII beta inhibitor 3
    3 Publications Verification

    PI4K Cancer
    PI4KIII beta inhibitor 3 is a novel and high effective PI4KIIIβ inhibitor with IC50 of 5.7 nM.
    PI4KIII beta inhibitor 3
  • HY-100603

    PI4K PI3K Infection
    GSK-F1 (Compound F1) is an orally active PI4KA inhibitor with pIC50 values of 8.0, 5.9, 5.8, 5.9, 5.9 and 6.4 against PI4KA, PI4KB, PI3KA, PI3KB, PI3KG and PI3KD, respectively. GSK-F1 can be used for HCV infection research .
    GSK-F1
  • HY-175067

    DHPI-4,5-P2 sodium salt; PI(4,5)P2 (6:0/6:0) sodium salt; PIP2[4',5'](6:0/6:0) sodium salt

    Biochemical Assay Reagents Others
    PtdIns-(4,5)-P2 (1,2-dihexanoyl) (sodium salt) is a synthetic analog of natural Ptdlns with C6:0 fatty acids at the sn-1 and sn-2 positions.
    PtdIns-(4,5)-P2 (1,2-dihexanoyl) sodium salt
  • HY-106012

    PI4K PI3K Cancer
    PI4K-IN-1 (compound 44) is a potent PI4KIII inhibitor, with pIC50 values of 9.0 and 6.6 for PI4KIIIα and PI4KIIIβ, respectively. PI4K-IN-1 also inhibits PI3Kα/β/γ/δ, with pIC50 values of 4.0/<3.7/5.0/<4.1, respectively .
    PI4K-IN-1
  • HY-110248

    PI4K HCV Infection
    MI 14 is a selective PI4KIIIβ inhibitor with IC50s of 54 nM, >100 μM, >100 μM for PI4KIIIβ, PI4KIIIα, PI4KIIα, respectively. MI 14 has antiviral activity against HCV 1b, CVB3, HRVM, HVC 2a .
    MI 14
  • HY-148075

    PI4K Infection
    PI4KIIIbeta-IN-11 is an inhibitor of PI4KIIIβ, with a mean pIC50 value of at least 9.1. PI4KIIIβ plays a key role in diseases research of RNA viruses and Plasmodium falciparum .
    PI4KIIIbeta-IN-11
  • HY-18748
    BQR-695
    1 Publications Verification

    NVP-BQR695

    PI4K Parasite Infection
    BQR-695 is a PI4KIIIβ inhibitor with IC50s of 80 and 3.5 nM for human PI4KIIIβ and Plasmodium variant of PI4KIIIβ, respectively.
    BQR-695
  • HY-112435

    PI4K Parasite Infection
    UCT943 is a next-generation Plasmodium falciparum PI4K inhibitor. UCT943 inhibits the P. vivax PI4K (PvPI4K) enzyme with an IC50 of 23 nM .
    UCT943
  • HY-100603A

    PI3K PI4K Infection
    (S)-GSK-F1 (Compound 28) is an inhibitor for type III phosphatidylinositol 4-kinase α (PI4KIIIα). (S)-GSK-F1 inhibits PI4Kα, PI4Kβ, PI4Kγ, PI3Kα, PI3Kβ and PI3Kδ with pIC50 of 8.3, 6.0, 5.6, 5.6, 5.1 and 5.6, respectively. (S)-GSK-F1 exhibits anti-hepatitis C virus (HCV) activity through inhibition of HCV replication. (S)-GSK-F1 exhibits moderate pharmacokinetic characters in rat model .
    (S)-GSK-F1
  • HY-103583

    PI4K Parasite Infection
    KDU731, an orally active C. parvum PI4K inhibitor with an IC50 value of 25 nM, blocks Cryptosporidium infection in vitro and in vivo . KDU731 is a promising agent candidate for the treatment of diarrhea caused by Cryptosporidium and meets a broad range of safety .
    KDU731
  • HY-174134

    PI4K PKG Parasite Infection
    PI4Kβ/PKG-IN-2 (Compound 20) is an orally active dual inhibitor of Plasmodium phosphatidylinositol 4-kinase beta (PI4Kβ) and cGMP-dependent protein kinase (PKG). PI4Kβ/PKG-IN-2 has potent inhibitory effects on Plasmodium. PI4Kβ/PKG-IN-2 is promising for research of malaria .
    PI4Kβ/PKG-IN-2
  • HY-157712

    Biochemical Assay Reagents Others
    08:0 PI(4,5)P2 ammonium is suitable for identifying its binding site at the transient receptor potential vanilloid 4 (TRPV 4 N) terminus .
    08:0 PI(4,5)P2 ammonium
  • HY-177725

    Molecular Glues PI4K Cancer
    MG degrader 2 (Compound CM-2) is a CRBN-dependent molecular glue degrader. MG degrader 2 induces ZFP91, FIZ1 and PI4KB degradation. MG degrader 2 has anti-proliferative activity against MM.1S cells (IC50 = 162 nM). MG degrader 2 can be used for the research of cancer, such as multiple myeloma .
    MG degrader 2
  • HY-112608

    PI3K Cancer
    CHMFL-PI3KD-317 is a highly potent, selective and orally active PI3Kδ inhibitor, with an IC50 of 6 nM, and exhibits over 10-1500 fold selectivity over other class I, II and III PIKK family isoforms, such as PI3Kα (IC50, 62.6 nM), PI3Kβ (IC50, 284 nM), PI3Kγ (IC50, 202.7 nM), PIK3C2A (IC50, >10000 nM), PIK3C2B (IC50, 882.3 nM), VPS34 (IC50, 1801.7 nM), PI4KIIIA (IC50, 574.1 nM) and PI4KIIIB (IC50, 300.2 nM). CHMFL-PI3KD-317 inhibits PI3Kδ-mediated Akt T308 phosphorylation in Raji cells, with an EC50 of 4.3 nM. CHMFL-PI3KD-317 has antiproliferative effects on cancer cells .
    CHMFL-PI3KD-317
  • HY-178775

    PI4K Parasite MAP4K PI3K Infection
    PI4K-IN-3 (Compound 27) is an orally active PI4K inhibitor with an IC50 of 1.9  nM for Plasmodium vivax PI4K. PI4K-IN-3 has no hERG channel inhibition and mammalian cytotoxicity. PI4K-IN-3 has significant selectivity against the human MINK1 and MAP4K4 kinases but with low selectivity against human PI3Kα and PI4. PI4K-IN-3 has potent antimalarial activity and significantly reduces parasitaemia in NSG mice mouse models of Plasmodium falciparum malaria .
    PI4K-IN-3
  • HY-175557

    PI4K Enterovirus Infection
    PI4K-IN-2 (Compound 30) is a highly selective type III phosphatidylinositol 4-kinase β (PI4KB) inhibitor (IC50=0.015 μM). PI4K-IN-2 is promising for research of human rhinovirus (HRV) .
    PI4K-IN-2
  • HY-175732

    PI4K Parasite Infection
    PI4Kβ-IN-1 is an orally active and selective PI4inhibitor, with an IC50 of 0.9 nM. PI4Kβ-IN-1 exhibits inhibitory activity against all stages of the P. falciparum life cycle, including blood, liver, and transmission stages. PI4Kβ-IN-1 demonstrates potent antimalarial efficacy in the mouse model infected with Plasmodium falciparum. PI4Kβ-IN-1 can be used for the study of malaria caused by Plasmodium falciparum .
    PI4Kβ-IN-1
  • HY-118525

    HCV PI4K Infection
    AL-9 is a inhibitor of PI4KIIIα, with the IC50 of 0.57 μM, that can inhibit HCV replication .
    AL-9
  • HY-150598

    PI4K PI3K Infection
    CHMFL-PI4K-127 (compound 15g) is an orally active, potent and high selective PfPI4K (Plasmodium falciparum PI4K kinase) inhibitor, with an IC50 of 0.9 nM. CHMFL-PI4K-127 exhibits potent activity against 3D7 Plasmodium falciparum, with an EC50 of 25.1 nM. CHMFL-PI4K-127 shows antimalaria efficacy .
    CHMFL-PI4K-127
  • HY-174130

    Parasite PI4K PKG Infection
    PI4Kβ/PKG-IN-1 (Compound 19) is an orally active dual inhibitor targeting Plasmodium phosphatidylinositol 4-kinase beta (PI4Kβ) and cGMP-dependent protein kinase (PKG). PI4Kβ/PKG-IN-1 exhibits potent antiplasmodial activity. PI4Kβ/PKG-IN-1 is promising for research of malaria .
    PI4Kβ/PKG-IN-1
  • HY-157645

    Biochemical Assay Reagents Others
    18:0-20:4 PI(4)P ammonium is a fatty acid.
    18:0-20:4 PI(4)P ammonium
  • HY-172255

    PI4K Apoptosis Autophagy PI3K Akt Cancer
    PI4KIII beta inhibitor 4 (Compound 16) is a selective PI4KIIIβ inhibitor with an IC50 of 0.005 μM. PI4KIIIβ inhibitor 4 induces tumor cell apoptosis, cell cycle arrest, and autophagy by inhibiting the PI3K/AKT pathway. PI4KIIIβ inhibitor 4 can be used in the study of cancer .
    PI4KIII beta inhibitor 4
  • HY-172256

    PI4K Cancer
    PI4KIII beta inhibitor 5 is a PI4KIIIβ inhibitor with an IC50 of 19 nM. PI4KIII beta inhibitor 5 can induce cancer cell apoptosis (Apoptosis), cell cycle arrest at the G2/M phase, and autophagy (Autophagy) by inhibiting the PI3K/AKT pathway. PI4KIII beta inhibitor 5 has also demonstrated significant antitumor activity in the H446 xenograft model of small cell lung cancer. PI4KIII beta inhibitor 5 can be used for research in the field of cancer therapy .
    PI4KIII beta inhibitor 5
  • HY-RS10468

    Small Interfering RNA (siRNA) PI4K Others

    Pi4ka Rat Pre-designed siRNA Set A contains three designed siRNAs for Pi4ka gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Pi4ka Rat Pre-designed siRNA Set A
    Pi4ka Rat Pre-designed siRNA Set A
  • HY-RS10469

    Small Interfering RNA (siRNA) PI4K Others

    PI4KB Human Pre-designed siRNA Set A contains three designed siRNAs for PI4KB gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    PI4KB Human Pre-designed siRNA Set A
    PI4KB Human Pre-designed siRNA Set A
  • HY-RS10470

    Small Interfering RNA (siRNA) PI4K Others

    Pi4kb Mouse Pre-designed siRNA Set A contains three designed siRNAs for Pi4kb gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Pi4kb Mouse Pre-designed siRNA Set A
    Pi4kb Mouse Pre-designed siRNA Set A
  • HY-RS10467

    Small Interfering RNA (siRNA) PI4K Others

    Pi4ka Mouse Pre-designed siRNA Set A contains three designed siRNAs for Pi4ka gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Pi4ka Mouse Pre-designed siRNA Set A
    Pi4ka Mouse Pre-designed siRNA Set A
  • HY-RS10471

    Small Interfering RNA (siRNA) PI4K Others

    Pi4kb Rat Pre-designed siRNA Set A contains three designed siRNAs for Pi4kb gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Pi4kb Rat Pre-designed siRNA Set A
    Pi4kb Rat Pre-designed siRNA Set A
  • HY-RS10466

    Small Interfering RNA (siRNA) PI4K Others

    PI4KA Human Pre-designed siRNA Set A contains three designed siRNAs for PI4KA gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    PI4KA Human Pre-designed siRNA Set A
    PI4KA Human Pre-designed siRNA Set A
  • HY-RS10464

    Small Interfering RNA (siRNA) Others

    PI4K2A Human Pre-designed siRNA Set A contains three designed siRNAs for PI4K2A gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    PI4K2A Human Pre-designed siRNA Set A
    PI4K2A Human Pre-designed siRNA Set A
  • HY-RS20578

    Small Interfering RNA (siRNA) Others

    Pi4k2a Mouse Pre-designed siRNA Set A contains three designed siRNAs for Pi4k2a gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Pi4k2a Mouse Pre-designed siRNA Set A
    Pi4k2a Mouse Pre-designed siRNA Set A
  • HY-RS10465

    Small Interfering RNA (siRNA) Others

    PI4K2B Human Pre-designed siRNA Set A contains three designed siRNAs for PI4K2B gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    PI4K2B Human Pre-designed siRNA Set A
    PI4K2B Human Pre-designed siRNA Set A
  • HY-RS12700

    Small Interfering RNA (siRNA) Others

    SERPINA4 Human Pre-designed siRNA Set A contains three designed siRNAs for SERPINA4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    SERPINA4 Human Pre-designed siRNA Set A
    SERPINA4 Human Pre-designed siRNA Set A
  • HY-157703

    1,2-Dioleoyl-sn-glycero-3-phospho-1′-myo-inositol-4′,5′-bisphosphate ammonium

    Biochemical Assay Reagents
    18:1 PI(4,5)P2 (1,2-Dioleoyl-sn-glycero-3-phospho-(1′-myo-inositol-4′,5′-bisphosphate) (ammonium)) is a kind of biochemical reagent.
    18:1 PI(4,5)P2
  • HY-161357

    PI4K Infection
    KR-27370 (compound 7f) is an antiviral agent and selective PI4KIIIβ/PI4KIIIα inhibitor (IC50: 3.1 nM/15.8 nM), against hRV, Ke Saatchivirus and other enteroviruses have inhibitory activity .
    KR-27370
  • HY-E70631

    PI3K Cancer
    PIP5K1A phosphorylates PI4P to synthesize the important signalling phospholipid PI(4,5)P2. This phospholipid also serves as the substrate for PI3K for conversion into PI(3,4,5)P3 to stimulate cell growth and survival. PIP5K1A has been directly implicated in breast cancer and prostate cancer. PIP5K1A Recombinant Human Active Lipid Kinase is a recombinant PIP5K1A protein that can be used to study PIP5K1A-related functions .
    PIP5K1A Recombinant Human Active Lipid Kinase
  • HY-139406

    PtdIns-(4)-P1 (1,2-dioctanoyl) ammonium; 08:0 PI(4)P ammonium

    Biochemical Assay Reagents Neurological Disease
    1,2-Dioctanoyl-sn-glycero-3-phospho-(1'-myo-inositol-4'-phosphate) (PtdIns-(4)-P1 (1,2-dioctanoyl)) ammonium is a synthetic phosphatidylinositol. 1,2-Dioctanoyl-sn-glycero-3-phospho-(1'-myo-inositol-4'-phosphate) ammonium can be used for the research of signal transduction research .
    1,2-Dioctanoyl-sn-glycero-3-phospho-1'-myo-inositol-4'-phosphate ammonium
  • HY-163765

    PI4K Potassium Channel Infection
    Antimalarial agent 41 (Compound 17) exhibits antimalarial activity, which inhibits Plasmodium falciparum with an IC50 of 40 nM (NF54 strain) and 76 nM (K1 strain). Antimalarial agent 41 is an inhibitor for P. falciparum phosphatidylinositol-4-kinase β (Pf PI4K) and hERG channel, with an IC50 of 53 nM and 3 μM. Antimalarial agent 41 exhibits cytotoxicity to CHO cells with an IC50 of 34 μM. Antimalarial agent 41 ameliorates the malaria infection and exhibits good pharmacokinetic characters in mouse models .
    Antimalarial agent 41

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