568558-66-7
Chemical Structure
NC03
- CAS No.: 568558-66-7
- Formula:C21H21N3O7S
- Molecular Weight:459.47
IUPAC Name: N-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-((5-(3,4,5-trimethoxyphenyl)-1,3,4-oxadiazol-2-yl)thio)acetamide
InChIKey: RBXOMDTTWFHGND-UHFFFAOYSA-N
SMILES: O=C(CSC1=NN=C(C2=CC(OC)=C(OC)C(OC)=C2)O1)NC3=CC=C4OCCOC4=C3
Biological Activity: NC03 is a PI4K2A inhibitor and reducing agent. NC03 inhibits the activity of PI4K2A, thereby reducing the production of PI4P in the cellular compartments where PI4K2A functions. NC03 rapidly induces a decrease in PI4P pools in the Golgi and endosomal compartments. NC03 reduces PI4P production in Rab7-positive late endosomes[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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NC03 | 98.79% | NC03 is a PI4K2A inhibitor and reducing agent. NC03 inhibits the activity of PI4K2A, thereby reducing the production of PI4P in the cellular compartments where PI4K2A functions. NC03 rapidly induces a decrease in PI4P pools in the Golgi and endosomal compartments. NC03 reduces PI4P production in Rab7-positive late endosomes. | ||||||||||||||||||||
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- [1]. Kumari S, et al. Enhancement of aqueous solubility and oral bioavailability of nelfinavir by complexation with β-cyclodextrin[J]. Tropical Journal of Pharmaceutical Research, 2015, 14(8): 1333-1340.
- [2]. Hofacker A F, et al. Mercury mobilization in a flooded soil by incorporation into metallic copper and metal sulfide nanoparticles[J]. Environmental science & technology, 2013, 47(14): 7739-7746.
- [3]. Sengupta N, et al. A large scale high-throughput screen identifies chemical inhibitors of phosphatidylinositol 4-kinase type II alpha. J Lipid Res. 2019;60(3):683-693. [Content Brief]
Keywords
