PMNL

By Targets:	Antibiotic (3) Apoptosis (1) FLAP (1) Isotope-Labeled Compounds (2) Leukotriene Receptor (3) Lipoxygenase (1)
By Research Areas:	Cancer (1) Inflammation/Immunology (6)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B0174A

Olsalazine	Leukotriene Receptor Antibiotic	Inflammation/Immunology
Olsalazine is a potent inhibitor of macrophages chemotaxis to LTB4 with an IC₅₀ value of 0.39 mM, also reduces the synthesis of 5-hydroxyeicosatetraenoic acid (5-HETE), 11-HETE, 12-HETE, and 15-HETE in polymorphonuclear leukocyte (PMNL) and mononuclear cells (MNL). Olsalazine can be used for researching ulcerative colitis. Anti-inflammatory activity .

HY-106200

CJ-13,610	Lipoxygenase	Inflammation/Immunology
CJ-13,610, a nonredox-type 5-LO inhibitor, dose dependently suppresses 5-LO product formation in ionophore A23187-stimulated PMNL in the absence of exogenous AA with an IC₅₀ of about 70 nM . PMNL: polymorphonuclear leukocytes; AA: arachidonic acid

HY-B0174AS1

Olsalazine-d3	Antibiotic Leukotriene Receptor Isotope-Labeled Compounds	Inflammation/Immunology
Olsalazine-d₃ is deuterated labeled Olsalazine (HY-B0174A). Olsalazine is a potent inhibitor of macrophages chemotaxis to LTB4 with an IC₅₀ value of 0.39 mM, also reduces the synthesis of 5-hydroxyeicosatetraenoic acid (5-HETE), 11-HETE, 12-HETE, and 15-HETE in polymorphonuclear leukocyte (PMNL) and mononuclear cells (MNL). Olsalazine can be used for researching ulcerative colitis. Anti-inflammatory activity .

HY-B0174AS2

Olsalazine-d3,15N	Antibiotic Leukotriene Receptor Isotope-Labeled Compounds	Inflammation/Immunology
Olsalazine-d₃, ¹⁵N is ¹⁵N and deuterated labeled Olsalazine (HY-B0174A). Olsalazine is a potent inhibitor of macrophages chemotaxis to LTB4 with an IC₅₀ value of 0.39 mM, also reduces the synthesis of 5-hydroxyeicosatetraenoic acid (5-HETE), 11-HETE, 12-HETE, and 15-HETE in polymorphonuclear leukocyte (PMNL) and mononuclear cells (MNL). Olsalazine can be used for researching ulcerative colitis. Anti-inflammatory activity .

HY-113776

15(S)-HETRE	Others	Inflammation/Immunology
15(S)-HETrE is the hydroxy-trienoic acid resulting from 15-lipoxygenation of dihomo-γ-linolenic acid. It is an inhibitor of 5-LO in human PMNL with an IC₅₀ value of 4.6 μM.1 In RBL cells, 15(S)-HETrE inhibits 5-LO, but is about 1/20 as potent as 15(S)-HpETE.

HY-10037

Quiflapon 1 Publications Verification MK-591	FLAP Apoptosis	Inflammation/Immunology
Quiflapon (MK-591) is a selective and specific 5-lipoxygenase-activating protein (FLAP) inhibitor with an IC₅₀ of 1.6 nM in a FLAP binding assay. Quiflapon is also a potent and orally active Leukotriene biosynthesis (LT) inhibitor, shows IC₅₀ values of 3.1 and 6.1 nM in intact human and elicited rat PMNLs, respectively. Quiflapon induces cell apoptosis .

HY-113484

Leukotriene B5 LTB5	Others	Cancer
Leukotriene B5 (LTB5) is a leukotriene with diverse biological activities. It is a metabolite of eicosapentaenoic acid formed through the 5-lipoxygenase (5-LO) pathway. LTB5 increases contraction of bullfrog lung strips ex vivo in a concentration-dependent manner. In vivo, LTB5 (100 nM) reduces tumor volume in mice injected with Tm1 murine melanoma cells. LTB5 also elicits chemokinesis and lysosomal enzyme release from polymorphonuclear leukocytes (PMNLs) 20- to 30-fold less, and induces platelet aggregation 8-fold less, potently than LTB4.

Species:	Human (2) Mouse (3) Cynomolgus (1)
Tag:	His (4) Tag Free (2)
Source:	HEK293 (5) CHO (1)

Cat. No.	Compare	Product Name	Species	Source

HY-P72507

	MMP-8 Protein, Human (HEK293, His) Neutrophil collagenase; Matrix metalloproteinase-8; MMP-8; PMNL collagenase; PMNL-CL; MMP8; CLG1	Human	HEK293
	MMP-8, also known as matrix metalloproteinase-8 or collagenase-2, is recognized for its enzymatic abilities, particularly its ability to break down fibrillar types I, II, and III collagen. This enzymatic activity suggests that MMP-8 plays an important role in the remodeling and turnover of collagen-rich tissues such as connective tissue, cartilage, and bone. MMP-8 Protein, Human (HEK293, His) is the recombinant human-derived MMP-8 protein, expressed by HEK293 , with C-10*His labeled tag. The total length of MMP-8 Protein, Human (HEK293, His) is 447 a.a., with molecular weight of approximately 64.09 kDa.

HY-P73298

	MMP-8 Protein, Human (HEK293) Neutrophil collagenase; MMP-8; PMNL-CL; CLG1	Human	HEK293
	MMP-8, also known as matrix metalloproteinase-8 or collagenase-2, is recognized for its enzymatic abilities, particularly its ability to break down fibrillar types I, II, and III collagen. This enzymatic activity suggests that MMP-8 plays an important role in the remodeling and turnover of collagen-rich tissues such as connective tissue, cartilage, and bone. MMP-8 Protein, Human (HEK293) is the recombinant human-derived MMP-8 protein, expressed by HEK293 , with N-Met labeled tag. The total length of MMP-8 Protein, Human (HEK293) is 447 a.a., with molecular weight of ~65 kDa.

HY-P73808

	MMP-8 Protein, Mouse (HEK293) Neutrophil collagenase; MMP-8; PMNL-CL; CLG1	Mouse	HEK293
	MMP-8 protein degrades different fibrillar collagens, such as type I, II, and III. It is implicated in the breakdown of collagen fibers during uterine involution. MMP-8 Protein, Mouse (HEK293) is the recombinant mouse-derived MMP-8 protein, expressed by HEK293, with tag free. The total length of MMP-8 Protein, Mouse (HEK293) is 445 a.a., with molecular weight of ~65 kDa.

HY-P78328

	MMP-8 Protein, Mouse (HEK293, His) MMP-8; PMNL-CL; CLG1; MMP8; Collagenase 2; PMNL-CL; HNC	Mouse	HEK293
	MMP-8 protein degrades different fibrillar collagens, such as type I, II, and III. It is implicated in the breakdown of collagen fibers during uterine involution. MMP-8 Protein, Mouse (HEK293, His) is the recombinant mouse-derived MMP-8 protein, expressed by HEK293 , with C-His labeled tag. The total length of MMP-8 Protein, Mouse (HEK293, His) is 445 a.a., with molecular weight of 65-70 kDa.

HY-P700793

	MMP-8 Protein, Cynomolgus (447a.a, HEK293, His) PMNL-CL; CLG1; MMP8; Collagenase 2; PMNL-CL; HNC	Cynomolgus	HEK293
	MMP-8, also known as matrix metalloproteinase-8 or collagenase-2, is recognized for its enzymatic abilities, particularly its ability to break down fibrillar types I, II, and III collagen. This enzymatic activity suggests that MMP-8 plays an important role in the remodeling and turnover of collagen-rich tissues such as connective tissue, cartilage, and bone. MMP-8 Protein, Cynomolgus (447a.a, HEK293, His) is the recombinant cynomolgus-derived MMP-8 protein, expressed by HEK293 , with C-His labeled tag. The total length of MMP-8 Protein, Cynomolgus (447a.a, HEK293, His) is 447 a.a., with molecular weight of 60-70 kDa.

HY-P73809

	MMP-8 Protein, Mouse (CHO, His) Neutrophil collagenase; MMP-8; PMNL-CL; CLG1	Mouse	CHO
	MMP-8 protein degrades different fibrillar collagens, such as type I, II, and III. It is implicated in the breakdown of collagen fibers during uterine involution. MMP-8 Protein, Mouse (CHO, His) is the recombinant mouse-derived MMP-8 protein, expressed by CHO, with C-His labeled tag. The total length of MMP-8 Protein, Mouse (CHO, His) is 465 a.a., with molecular weight of ~57 kDa.


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Cat. No.	Product Name	Chemical Structure

HY-B0174AS1

Olsalazine-d3
Olsalazine-d₃ is deuterated labeled Olsalazine (HY-B0174A). Olsalazine is a potent inhibitor of macrophages chemotaxis to LTB4 with an IC₅₀ value of 0.39 mM, also reduces the synthesis of 5-hydroxyeicosatetraenoic acid (5-HETE), 11-HETE, 12-HETE, and 15-HETE in polymorphonuclear leukocyte (PMNL) and mononuclear cells (MNL). Olsalazine can be used for researching ulcerative colitis. Anti-inflammatory activity .

Olsalazine-d3

Olsalazine-d₃ is deuterated labeled Olsalazine (HY-B0174A). Olsalazine is a potent inhibitor of macrophages chemotaxis to LTB4 with an IC₅₀ value of 0.39 mM, also reduces the synthesis of 5-hydroxyeicosatetraenoic acid (5-HETE), 11-HETE, 12-HETE, and 15-HETE in polymorphonuclear leukocyte (PMNL) and mononuclear cells (MNL). Olsalazine can be used for researching ulcerative colitis. Anti-inflammatory activity .

HY-B0174AS2

Olsalazine-d3,15N
Olsalazine-d₃, ¹⁵N is ¹⁵N and deuterated labeled Olsalazine (HY-B0174A). Olsalazine is a potent inhibitor of macrophages chemotaxis to LTB4 with an IC₅₀ value of 0.39 mM, also reduces the synthesis of 5-hydroxyeicosatetraenoic acid (5-HETE), 11-HETE, 12-HETE, and 15-HETE in polymorphonuclear leukocyte (PMNL) and mononuclear cells (MNL). Olsalazine can be used for researching ulcerative colitis. Anti-inflammatory activity .

Olsalazine-d3,15N

Olsalazine-d₃, ¹⁵N is ¹⁵N and deuterated labeled Olsalazine (HY-B0174A). Olsalazine is a potent inhibitor of macrophages chemotaxis to LTB4 with an IC₅₀ value of 0.39 mM, also reduces the synthesis of 5-hydroxyeicosatetraenoic acid (5-HETE), 11-HETE, 12-HETE, and 15-HETE in polymorphonuclear leukocyte (PMNL) and mononuclear cells (MNL). Olsalazine can be used for researching ulcerative colitis. Anti-inflammatory activity .

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P83285

MMP8 Antibody (YA3030)

HNC; CLG1; MMP-8; PMNL-CL; COLLAGENASE I; NEUTROPHIL; matrix metalloproteinase 8
WB, IHC-P, ICC/IF, IP, FC Human, Mouse, Rat

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