903574-41-4
Chemical Structure
Hexacyclinol
- CAS No.: 903574-41-4
- Formula:C23H28O7
- Molecular Weight:416.46
InChIKey: PFZFRWWDGXFULQ-NHFKQXEKSA-N
SMILES: COC(C)([C@@H]1[C@@]23[C@@]([C@@]4([H])C(C([C@]5([H])[C@](O5)([H])[C@@H]4O)=O)=C1)([H])[C@@]([C@@]6([H])[C@@](O6)([H])C3=O)([H])O[C@@H]2/C=C(C)\C)C
Biological Activity: Hexacyclinol has moderate anti-Gram-positive bacteria activity, 4-40 μg/mL can inhibit the production of oxidants by polymorphonuclear neutrophils (PMNL) stimulated by zymosan. Hexacyclinol inhibits the growth of L-930 and K 562 cells with IC50s of 1.4 μg/mL and 0.4 μg/mL, respectively, and the IC50 of HeLa cells is 10 μg/mL. Hexacyclinol also has an anti-Plasmodium effect, and its IC50 for Plasmodium falciparum is 2.4 μg/mL[1].
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Hexacyclinol | Hexacyclinol has moderate anti-Gram-positive bacteria activity, 4-40 μg/mL can inhibit the production of oxidants by polymorphonuclear neutrophils (PMNL) stimulated by zymosan. Hexacyclinol inhibits the growth of L-930 and K 562 cells with IC50s of 1.4 μg/mL and 0.4 μg/mL, respectively, and the IC50 of HeLa cells is 10 μg/mL. Hexacyclinol also has an anti-Plasmodium effect, and its IC50 for Plasmodium falciparum is 2.4 μg/mL. | |||||||||||||||||||||
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