PTHR1

By Targets:	PTHR (12) Androgen Receptor (1) Arrestin (2) Bacterial (1) PKC (1) Reference Standards (1) Small Interfering RNA (siRNA) (4)
By Research Areas:	Cancer (4) Endocrinology (7) Infection (1) Metabolic Disease (6)
Oligonucleotides:	Rat Pre-designed siRNA Sets (2) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (4)

Targets Recommended: PTHR

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-108742

Abaloparatide 3 Publications Verification BA 058; BIM 44058	PTHR Arrestin	Metabolic Disease Cancer
Abaloparatide (BA 058) is a parathyroid hormone receptor 1 (PTHR1) analog. Abaloparatide also is a selective *PTHR1* activator. Abaloparatide enhances Gs/cAMP signaling and β-arrestin recruitment. Abaloparatide enhances bone formation and cortical structure in mice. Abaloparatide has the potential for the research of osteoporosis ^[1] .

HY-100856

PCO371	PTHR	Endocrinology
PCO371 is an orally active full agonist of parathyroid hormone receptor 1 (PTHR1), with no effect on PTH type 2 receptor.

HY-15103

AH3960	PTHR Androgen Receptor	Cancer
AH3960 (compound 16c) is an antagonist of androgen receptor. AH3960 binds wild as well as T877 mutant type androgen receptors. AH3960 selectively inhibits T877 with an IC₅₀ value of 0.82 μM. AH3960 also serves as an agonist of parathyroid hormone receptor-1 (PTHR1) ^[1] .

HY-148350

DS69910557	PTHR	Cancer
DS69910557 is a potent, selective and orally activehuman parathyroid hormone receptor 1 (hPTHR1) antagonist. DS69910557 has antagonistic activity for PTHR1 with an IC₅₀ value of 0.08 μM. DS69910557 can be used for the research of hyperparathyroidism, hypercalcemia of malignancy and osteoporosis ^[1].

HY-108742A

Abaloparatide TFA 3 Publications Verification BA 058 TFA; BIM 44058 TFA	Arrestin PTHR	Metabolic Disease Endocrinology Cancer
Abaloparatide TFA (BA 058 TFA) is a parathyroid hormone receptor 1 (PTHR1) analogue. Abaloparatide TFA also is a selective *PTHR1* activator. Abaloparatide TFA enhances Gs/cAMP signaling and β-arrestin recruitment. Abaloparatide TFA enhances bone formation and cortical structure in mice. Abaloparatide TFA has the potential for the research of osteoporosis ^[1] .

HY-125879

DS08210767	PTHR	Metabolic Disease Endocrinology
DS08210767 is a highly potent, orally bioavailable *PTHR1* antagonist with IC₅₀ of 90 nM ^[1].

HY-131206

DS37571084	PTHR	Metabolic Disease Endocrinology
DS37571084 is an orally active and potent antagonist of the parathyroid hormone type 1 receptor (PTHR1), with an IC₅₀ value of 0.17 μM. DS37571084 can be used for the study of hyperparathyroidism ^[1].

HY-113918

SW-106	PTHR	Metabolic Disease
SW-106 is a parathyroid hormone receptor 1 (PTHR1) antagonist. SW106 antagonizes PTHR1-mediated cAMP signaling induced by the peptide analog, M-PTH (1-11), as well as by the native PTH (1-9) sequence, as tethered to the extracellular end of transmembrane domain (TMD) helix-1 of the receptor. SW-106 can be used for the research of metabolic disease ^[1].

HY-120398

CH5447240	PTHR	Endocrinology
CH5447240 is an agonist for parathyroid hormone receptor 1 (PTHR1), that inhibits human PTHR1 with an EC₅₀ of 12 μM. CH5447240 exhibits good metabolic stability in human liver microsomes. CH5447240 increases serum calcium levels in rats. CH5447240 can be used in research about hypoparathyroidism ^[1].

HY-P4856

pTH-Related Protein (1-40) (human, mouse, rat)	PTHR PKC	Endocrinology
pTH-Related Protein (1-40) (human, mouse, rat) stimulates calcium uptake in rat intestinal cells through PTHR1 receptor and PKCα/β signaling pathways. pTH-Related Protein (1-40) up-regulates parathyroid hormone 1 receptor (PTHR1) protein, four transcellular calcium transporters, potential vanillin member 6 (TRPV6), calcium-binding protein-D9K (CaBP-D9k), sodium-calcium Exchanger 1 (NCX1) and plasma membrane calcium ATPase 1 (PMCA1) ^[1].

HY-186200

PTHR1 antagonist 1	PTHR	Metabolic Disease
PTHR1 antagonist 1 (Compound 18) is a *PTHR1* antagonist with an IC₅₀ of 0.090 µM. PTHR1 antagonist 1 is applicable to the research of calcium metabolism disorders ^[1].

HY-RS11395

PTH1R Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
PTH1R Human Pre-designed siRNA Set A contains three designed siRNAs for PTH1R gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

PTH1R Human Pre-designed siRNA Set A PTH1R Human Pre-designed siRNA Set A

HY-100856R

PCO371 (Standard)	PTHR Reference Standards	Endocrinology
PCO371 (Standard) is the analytical standard of PCO371 (HY-100856). This product is intended for research and analytical applications. PCO371 is an orally active full agonist of parathyroid hormone receptor 1 (PTHR1), with no effect on PTH type 2 receptor.

HY-RS17667

Pth1r Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Pth1r Mouse Pre-designed siRNA Set A contains three designed siRNAs for Pth1r gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Pth1r Mouse Pre-designed siRNA Set A Pth1r Mouse Pre-designed siRNA Set A

HY-P1709

Protactin	Bacterial	Infection
Protactin is a pentapeptide lactone produced by Streptomyces cucumeris strain L703-4 (ATCC 53784) with significant antioxidant properties. Protactin can be converted to actinomycin Zp by ferrocyanide oxidation. Actinomycin Zp exhibits potent antibacterial activity in vitro and has significant antitumor effects against P-388 leukemia in a mouse model ^[1].

HY-RS24128

Pth1r Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Pth1r Rat Pre-designed siRNA Set A contains three designed siRNAs for Pth1r gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Pth1r Rat Pre-designed siRNA Set A Pth1r Rat Pre-designed siRNA Set A

HY-RS23068

Pth Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Pth Rat Pre-designed siRNA Set A contains three designed siRNAs for Pth gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Pth Rat Pre-designed siRNA Set A Pth Rat Pre-designed siRNA Set A

Cat. No.	Product Name	Target	Research Area

HY-108742

Abaloparatide 3 Publications Verification BA 058; BIM 44058	PTHR Arrestin	Metabolic Disease Cancer
Abaloparatide (BA 058) is a parathyroid hormone receptor 1 (PTHR1) analog. Abaloparatide also is a selective *PTHR1* activator. Abaloparatide enhances Gs/cAMP signaling and β-arrestin recruitment. Abaloparatide enhances bone formation and cortical structure in mice. Abaloparatide has the potential for the research of osteoporosis ^[1] .

HY-108742A

Abaloparatide TFA 3 Publications Verification BA 058 TFA; BIM 44058 TFA	Arrestin PTHR	Metabolic Disease Endocrinology Cancer
Abaloparatide TFA (BA 058 TFA) is a parathyroid hormone receptor 1 (PTHR1) analogue. Abaloparatide TFA also is a selective *PTHR1* activator. Abaloparatide TFA enhances Gs/cAMP signaling and β-arrestin recruitment. Abaloparatide TFA enhances bone formation and cortical structure in mice. Abaloparatide TFA has the potential for the research of osteoporosis ^[1] .

HY-P4856

pTH-Related Protein (1-40) (human, mouse, rat)	PTHR PKC	Endocrinology
pTH-Related Protein (1-40) (human, mouse, rat) stimulates calcium uptake in rat intestinal cells through PTHR1 receptor and PKCα/β signaling pathways. pTH-Related Protein (1-40) up-regulates parathyroid hormone 1 receptor (PTHR1) protein, four transcellular calcium transporters, potential vanillin member 6 (TRPV6), calcium-binding protein-D9K (CaBP-D9k), sodium-calcium Exchanger 1 (NCX1) and plasma membrane calcium ATPase 1 (PMCA1) ^[1].

HY-P1709

Protactin	Bacterial	Infection
Protactin is a pentapeptide lactone produced by Streptomyces cucumeris strain L703-4 (ATCC 53784) with significant antioxidant properties. Protactin can be converted to actinomycin Zp by ferrocyanide oxidation. Actinomycin Zp exhibits potent antibacterial activity in vitro and has significant antitumor effects against P-388 leukemia in a mouse model ^[1].

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-P1709

Protactin	Microorganisms Antibiotics Other Antibiotics Source Classification	Bacterial
Protactin is a pentapeptide lactone produced by Streptomyces cucumeris strain L703-4 (ATCC 53784) with significant antioxidant properties. Protactin can be converted to actinomycin Zp by ferrocyanide oxidation. Actinomycin Zp exhibits potent antibacterial activity in vitro and has significant antitumor effects against P-388 leukemia in a mouse model ^[1].

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P705968

	PTH1R Protein, Rat (HEK293, His) Parathyroid hormone/parathyroid hormone-related peptide receptor; PTH/PTHRP type I receptor (PTH/PTHR receptor); Parathyroid hormone 1 receptor (PTH1 receptor); Pth1r; PTHR, PTHR1	Rat	HEK293

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Host:	Mouse (2) Rabbit (2)
Reactivity:	Human (4)
Application:	IHC-P (2) ICC/IF (2) IP (2) WB (2) ELISA (2)
Isotype:	IgG (2) IgG1 (2)
Conjugation:	Non-conjugated (4)
Clonality:	Monoclonal (2) Monoclonal Antibody (1) Recombinant (2)
Modification:	Unmodified (3)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P84478

	Parathyroid Hormone Receptor 1 Antibody (YA4175) PFE; PTHR; PTHR1; MGC138426; MGC138452; PTH1R	IHC-P, ICC/IF, ELISA	Human
	Parathyroid Hormone Receptor 1 Antibody (YA4175) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Parathyroid Hormone Receptor 1.

HY-P84478A

	Parathyroid Hormone Receptor 1 Antibody (YA4175)(PBS only) PFE; PTHR; PTHR1; MGC138426; MGC138452; PTH1R	IHC-P, ICC/IF, ELISA	Human
	Parathyroid Hormone Receptor 1 Antibody (YA4175) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Parathyroid Hormone Receptor 1.

HY-P85340

	Parathyroid Hormone Receptor 1 Antibody (YA5032) PTH1R; PTHR; PTHR1; Parathyroid hormone/parathyroid hormone-related peptide receptor; PTH/PTHRP type I receptor; PTH/PTHR receptor; Parathyroid hormone 1 receptor; PTH1 receptor	WB, IP	Human
	Parathyroid Hormone Receptor 1 Antibody (YA5032) is a Rabbit-derived and non-conjugated monoclonal antibody, targeting to Parathyroid Hormone Receptor 1.

HY-P81707

	Parathyroid Hormone Receptor 1 Antibody (YA1452) PTH1R; PTHR; PTHR1; Parathyroid hormone/parathyroid hormone-related peptide receptor; PTH/PTHRP type I receptor; PTH/PTHR receptor; Parathyroid hormone 1 receptor; PTH1 receptor	WB, IP	Human
	Parathyroid Hormone Receptor 1 Antibody (YA1452) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Parathyroid Hormone Receptor 1.

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Cat. No.	Product Name		Classification

HY-RS11395

PTH1R Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
PTH1R Human Pre-designed siRNA Set A contains three designed siRNAs for PTH1R gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS17667

Pth1r Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Pth1r Mouse Pre-designed siRNA Set A contains three designed siRNAs for Pth1r gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS24128

Pth1r Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Pth1r Rat Pre-designed siRNA Set A contains three designed siRNAs for Pth1r gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS23068

Pth Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Pth Rat Pre-designed siRNA Set A contains three designed siRNAs for Pth gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

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