Parathyroid Hormone Receptor 1 Antibody (YA1452)
(Synonyms: PTH1R; PTHR; PTHR1; Parathyroid hormone/parathyroid hormone-related peptide receptor; PTH/PTHrP type I receptor; PTH/PTHr receptor; Parathyroid hormone 1 receptor; PTH1 receptor)Parathyroid Hormone Receptor 1 Antibody (YA1452) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Parathyroid Hormone Receptor 1.
-
Host:
Rabbit
-
Isotype:
IgG
-
Application:
WB, IP
-
Reactivity :
Human
-
Formulation:
Supplied in rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
-
Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
|
IP
IP: Immunoprecipitation
|
|---|---|---|
| Dilution Ratio | 1:500-1:1000 | 1:50 |
Product Details
Parathyroid Hormone Receptor 1 Antibody (YA1452) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Parathyroid Hormone Receptor 1.
-
Host Rabbit
-
Clonality Recombinant, Monoclonal
-
Species ReactivityHuman
-
Observed Molecular WeightObserved band size: 66 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
-
Calculated Molecular Weight Predicted band size: 66 kDa
A synthesized peptide derived from human Parathyroid Hormone Receptor 1 aa50-200/593.
Endogenous
Affinity Chromatography
Non-conjugated
Unmodified
IgG
Product Properties
-
Appearance
Liquid
-
Formulation
Supplied in rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
-
Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
-
Shipping
Shipping with blue ice.
Background
-
Function
Parathyroid Hormone Receptor 1 is a G-protein-coupled receptor for parathyroid hormone (PTH) and for parathyroid hormone-related peptide (PTHLH). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (cAMP). PTH1R is coupled to G(s) G alpha proteins and mediates activation of adenylate cyclase activity. PTHLH dissociates from PTH1R more rapidly than PTH; as consequence, the cAMP response induced by PTHLH decays faster than the response induced by PTH[1][2][3][4][5][6][7][8].
-
Subcellular Localization
Cell membrane; Multi-pass membrane protein
-
Expression
Tissue_specificity:It is expressed in most tissues, with the highest concentrations found in the kidneys, bones, and liver. -
Subunit
Homodimer in the absence of bound ligand (PubMed:19674967, PubMed:20172855, PubMed:27160269, PubMed:30975883). Peptide hormone binding leads to dissociation of the homodimer (PubMed:19674967, PubMed:20172855)
-
SwissProt ID
-
Synonyms
PTH1R; PTHR; PTHR1; Parathyroid hormone/parathyroid hormone-related peptide receptor; PTH/PTHrP type I receptor; PTH/PTHr receptor; Parathyroid hormone 1 receptor; PTH1 receptor
-
Research Field
Signal Transduction
Documentation
Powered by Bioz
