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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
8 Results for "
PYCR1
" in MedChemExpress (MCE) Product Catalog:
Products (8)
8 Results for "PYCR1" in MCE Product Catalog:
2
2 Cited Publications
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2-APQC is an orally active and selective agonist of Sirtuin-3 (SIRT3) (Kd=2.756 μM), antagonizes Isoproterenol/ISO (HY-B0468)-induced cytotoxicity. 2-APQC activates the SIRT3-PYCR1 axis to enhance mitochondrial proline metabolism and inhibit the ROS-p38MAPK pathway by inhibiting signaling pathways such as mTOR-p70S6K, JNK, and TGF-β/Smad3. 2-APQC also activates the AMPK-Parkin axis to alleviate myocardial hypertrophy and fibrosis and protect cardiac function. 2-APQC can be used in the study of heart failure [1].
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PYCR1-IN-1 (compound 4) is a pyrroline-5-carboxylate reductase 1 (PYCR1) inhibitor with an IC50 of 8.8 µM. PYCR1-IN-1 has anticancer effects [1].
Cat. No.: HY-RS11486
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PYCR1 Human Pre-designed siRNA Set A contains three designed siRNAs for PYCR1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS18544
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Pycr1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Pycr1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS25026
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Pycr1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Pycr1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-P703182
Synonyms: PYCR1; ARCL2B; Pyrroline-5-Carboxylate Reductase 1; ARCL3B; P5C; P5CR 1; Pyrroline-5-Carboxylate Reductase 1, Mitochondrial; PIG45; P5C Reductase 1; PP222; Truncated Pyrroline-5-Carboxylate Reductase 1; P5CR; Proliferation-Inducing Protein 45; PRO3; Pyrro
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
