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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
34 Results for "
Pyridazine
" in MedChemExpress (MCE) Product Catalog:
Products (34)
34 Results for "Pyridazine" in MCE Product Catalog:
Cat. No.: HY-W007494
CAS No.: 289-80-5
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2 Cited Publications
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DNMT3A-IN-1 (compound 1) is an effective and selective DNMT3A inhibitor. DNMT3A-IN-1 exhibits inhibitory activity against DNMT3A, with KI values ranging from 9.16 to 18.85 μM (AdoMet) and 11.37 to 23.34 μM (poly dI-dC). DNMT3A-IN-1 can induce apoptosis in acute myeloid leukemia (AML) cell lines (Apoptosis) .
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2 Cited Publications
Cat. No.: HY-150753
CAS No.: 2097925-52-3
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RS6212 is a specific LDH (lactate dehydrogenase) inhibitor with an IC50 value of 12.03 μM . RS6212 inhibits tumor growth and exhibits potent anticancer activity in multiple cancer cell lines .
Synonyms: 4-Nitrophenyl a-D-mannopyranoside
Cat. No.: HY-W002066
CAS No.: 50681-25-9
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Hydracarbazine is a pyridazine. Hydracarbazine can effectively lower blood pressure, it can be used for the research of high blood pressure .
Cat. No.: HY-W001297
CAS No.: 1121-79-5
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3-Chloro-6-methylpyridazine is a substituted pyridazine derivative containing an electron-withdrawing chlorine atom and an electron-donating methyl group. Pyridazine compounds generally possess pharmacological activities such as antibacterial and anti-inflammatory properties. 3-Chloro-6-methylpyridazine can serve as an organic ligand for constructing organic-inorganic hybrid chloroantimonate materials with semiconducting behavior. 3-Chloro-6-methylpyridazine can be used in studies related to optoelectronic devices, photodetectors, and photocatalysis .
Cat. No.: HY-W790266
CAS No.: 1810726-08-9
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Polygodial pyridazine (compound 7) is a polygodial analogue and a TRPV1 agonist with a GI50 of 72 μM against MCF-7. Polygodial pyridazine can be utilized in cancer research .
Cat. No.: HY-176439
CAS No.: 2758789-03-4
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AChE-IN-88 (Compound 26) is a novel pyridazine derivative. AChE-IN-88 is an orally active multi-target ligand for Alzheimer's disease (AD) that inhibits both acetylcholinesterase (AChE) and amyloid β protein (Aβ) aggregation (pIC50: 7.16) .
Cat. No.: HY-106885
CAS No.: 133220-91-4
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F 2692 is an orally effective derivative of pyridazine. F 2692 has significant anti anxiety effects. F 2692 also has activities such as anticonvulsant, sedative, and muscle relaxant. F 2692 can be used for research on neurological disorders such as anxiety disorders .
Cat. No.: HY-59354S1
CAS No.: 2140327-62-2
Synonyms: 1,2-Dihydro-3,6-Pyridazine-13C4-dione; 3,6-DihydroxyPyridazine-13C4; 3,6-Pyridazine-13C4-diol; Maleic hydrazide-13C4
Cat. No.: HY-161174
CAS No.: 3033849-05-4
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Carbonic anhydrase inhibitor 17 (compound 7c) ,pyridazine-tethered sulfonamide, is a carbonic anhydrase II inhibitor with IC50 of 0.63 nM .
Cat. No.: HY-155648
CAS No.: 121041-08-5
Tuberculosis inhibitor 6 (compound 2c) is a 3-methoxy-2-phenylimidazo[1,2-b]pyridazine derivative that shows highly active against Mycobacterium tuberculosis (MIC90 of ≤1.66 μM) and Mycobacterium marinum (MIC90 of 2.65 μM) .
Cat. No.: HY-155649
CAS No.: 121041-20-1
Tuberculosis inhibitor 7 (compound 2d) is a 3-methoxy-2-phenylimidazo[1,2-b]pyridazine derivative that shows highly active against Mycobacterium tuberculosis (MIC90 of 0.63 μM) and Mycobacterium marinum (MIC90 of 0.63 μM) .
Cat. No.: HY-155650
CAS No.: 141353-07-3
Tuberculosis inhibitor 8 (compound 3b) is a 3-methoxy-2-phenylimidazo[1,2-b]pyridazine derivative that shows highly active against Mycobacterium tuberculosis (MIC90 of 0.69 μM) and Mycobacterium marinum (MIC90 of 0.69 μM) .
Cat. No.: HY-161921
Antifungal agent 108 (compound 14d), an original imidazo[1,2-b]pyridazine derivative, shows potent antifungal activity against Madurella mycetomatis (MM55 strain) with an IC50 of 0.9 μM. Antifungal agent 108 exhibits an IC50 of 14.3 μM on cell viability of NIH-3T3 murine fibroblast .
Cat. No.: HY-157995
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Dyrk1a-in-7 (Compound 29) is a selective DYRK1A kinase inhibitor, and has good kinase selectivity for CLK1 kinase. The IC50 value of DYRK1A is 28 nM. For CLK2, Kd is 17.5 nM. Dyrk1a-in-7 can be used in the research of cancer, type Ⅱ diabetes and neurological diseases .
Cat. No.: HY-164055
CAS No.: 202828-10-2
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HL1 is a Schiff base ligand. HL1 exhibits chelation-enhanced fluorescence effect when forming complexes and can be used as a fluorescent probe for metal ions. HL1 can be used for the research of cancer .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
