5 Results for "

Rapamycin (Standard)

" in MedChemExpress (MCE) Product Catalog:
Products (5)

5 Results for "Rapamycin (Standard)" in MCE Product Catalog:

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Cat. No.: HY-10219R
CAS No.: 53123-88-9
Synonyms: Sirolimus (Standard); AY-22989 (Standard); NSC 226080 (Standard)
Rapamycin (Standard) (Sirolimus (Standard)) is the analytical standard of Rapamycin (HY-10219). This product is intended for research and analytical applications. Rapamycin (Sirolimus; AY 22989) is a potent and specific blood-brain barrier-transmissible mTOR inhibitor with an IC50 of 0.1 nM in HEK293 cells. Rapamycin is a molecular glue that binds FKBP12 and mTOR proteins together, thereby inhibiting mTOR kinase activity. Rapamycin binds to FKBP12 and specifically acts as an allosteric inhibitor of mTORC1. Rapamycin is an autophagy activator, an immunosuppressant .
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Cat. No.: HY-10218R
CAS No.: 159351-69-6
Synonyms: RAD001 (Standard); SDZ-RAD (Standard)
Research Areas:  

Cancer

Everolimus (Standard) is the analytical standard of Everolimus. This product is intended for research and analytical applications. Everolimus (RAD001) is a Rapamycin (HY-10219) derivative and a potent, selective and orally active mTOR1 inhibitor. Everolimus binds to FKBP-12 to generate an immunosuppressive complex. Everolimus inhibits tumor cells proliferation and induces cell apoptosis and autophagy. Everolimus has potent immunosuppressive and anticancer activities .
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Cat. No.: HY-19555AR
CAS No.: 148554-65-8
Synonyms: SecoRapamycin A monosodium (Standard)
Research Areas:  

Others

Phenglutarimid (hydrochloride) (Standard) is the analytical standard of Phenglutarimid (hydrochloride). This product is intended for research and analytical applications. Phenglutarimid hydrochloride is an anticholinergic used as an antiparkinsonian agent.
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Cat. No.: HY-10949R
CAS No.: 67200-34-4
Research Areas:  

Cancer

SMER3 (Standard) is the analytical standard of SMER3 (HY-10949). This product is intended for research and analytical applications. SMER3, a Rapamycin enhancer, is a selective Skp1-Cullin-F-box (SCF)Met30 ubiquitin ligase inhibitor. SMER3 enhances Rapamycin's growth inhibitory effect by inhibition of SCFMet30 .
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Cat. No.: HY-101920R
CAS No.: 1644443-47-9
Autophinib (Standard) is the analytical standard of Autophinib (HY-101920). This product is intended for research and analytical applications. Autophinib is a potent, selective autophagy inhibitor with IC50s of 90 nM and 40 nM for starvation- and Rapamycin-induced autophagy, respectively. Autophinib is also an ATP competitive Vacuolar Protein Sorting 34 (VPS34) inhibitor with an IC50 of 19 nM. Autophinib inhibits autophagy induced by starvation or Rapamycin by targeting VPS34 .
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