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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
3 Results for "
SMase-IN-1
" in MedChemExpress (MCE) Product Catalog:
Products (3)
3 Results for "SMase-IN-1" in MCE Product Catalog:
Cat. No.: HY-170650
CAS No.: 33017-85-5
Research Areas:
SMase-IN-1 (Compound 4) is a bacterial sphingomyelinase enzyme (SMase) inhibitor (IC50 value for B. cereus SMase is 6.43 µM). SMase-IN-1 also inhibits eqBuChE (59.50% inhibition rate at 50 µM concentration). SMase-IN-1 forms a complex with Cu 2+ in biometal interactions. SMase-IN-1 reduces B. cereus-induced hemolysis on sheep erythrocytes [1].
Cat. No.: HY-173538
Synonyms: NBD SM(d18:1/6:0)
Target:
Research Areas:
C6 NBD Sphingomyelin (d18:1/6:0) (NBD SM(d18:1/6:0)) is a fluorescent short-chain analogue of Sphingomyelin (HY-113498). C6 NBD Sphingomyelin (d18:1/6:0) has neutral sphingomyelinase (N-SMase) activity .
Cat. No.: HY-182413
CAS No.: 849020-48-0
Target:
Research Areas:
SMases D-IN-1 is an inhibitor of SMase D (sphingomyelinase D) from Loxosceles (brown recluse spider), with a Ki value of 0.54 μM. SMases D-IN-1 inhibits the hydrolysis of sphingomyelin substrates by recombinant and native SMases D, reduces the binding ability of SMases D to human red blood cells, and prevents the shedding of glycophorin C from the surface of human red blood cells. SMases D-IN-1 partially inhibits Loxosceles venom-induced death of human keratinocytes and also suppresses systemic reactions triggered by Loxosceles venom. SMases D-IN-1 can be used in studies related to recluse spider envenomation [1].
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
