33017-85-5
33017-85-5
Chemical Structure
SMase-IN-1
- CAS No.: 33017-85-5
- Formula:C8H5ClN2OS
- Molecular Weight:212.66
InChIKey: RXWIQURSYQCLTG-UHFFFAOYSA-N
SMILES: O=C(C1=CC(Cl)=CC=C1N2)NC2=S
Biological Activity: SMase-IN-1 (Compound 4) is a bacterial sphingomyelinase enzyme (SMase) inhibitor (IC50 value for B. cereus SMase is 6.43 µM). SMase-IN-1 also inhibits eqBuChE (59.50% inhibition rate at 50 µM concentration). SMase-IN-1 forms a complex with Cu2+ in biometal interactions. SMase-IN-1 reduces B. cereus-induced hemolysis on sheep erythrocytes[1].
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SMase-IN-1 | SMase-IN-1 (Compound 4) is a bacterial sphingomyelinase enzyme (SMase) inhibitor (IC50 value for B. cereus SMase is 6.43 µM). SMase-IN-1 also inhibits eqBuChE (59.50% inhibition rate at 50 µM concentration). SMase-IN-1 forms a complex with Cu2+ in biometal interactions. SMase-IN-1 reduces B. cereus-induced hemolysis on sheep erythrocytes. | |||||||||||||||||||||
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References
Keywords
