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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
41 Results for "
SORT
" in MedChemExpress (MCE) Product Catalog:
Products (41)
41 Results for "SORT" in MCE Product Catalog:
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12 Publications Verification
Research Areas:
Autophinib is a potent, selective autophagy inhibitor with IC50s of 90 nM and 40 nM for starvation- and Rapamycin-induced autophagy, respectively. Autophinib is also an ATP competitive Vacuolar Protein Sorting 34 (VPS34) inhibitor with an IC50 of 19 nM. Autophinib inhibits autophagy induced by starvation or Rapamycin by targeting VPS34 .
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Endosidin-2 (ES2) is a selective inhibitor targeting the conserved exosome subunit EXO70. Endosidin-2 binds to the C-terminal domain of EXO70, inhibiting exocytosis and endosomal recycling, while promoting vacuolar trafficking in plant cells. Endosidin-2 interferes with the EXO70-mediated vesicle-to-plasma membrane anchoring process, leading to abnormal aggregation of auxin transporters (such as PIN2) in the cytoplasm and redirected to vacuolar degradation, while causing abnormal Golgi structure (such as cup-shaped or ring-shaped vesicles cisternae formation). Endosidin-2 can inhibit exocytosis in plant and mammalian cells and is mainly used to study the dynamic regulation of membrane trafficking (such as polar growth, vesicle sorting) .
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1 Cited Publications
Cat. No.: HY-W747072
CAS No.: 71781-33-4
Synonyms: 3-Sulfocholyl Taurine; TCA3S
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3-Sulfo-taurocholic Acid Disodium Salt (3-Sulfocholyl Taurine; TCA3S) is a metabolite of the conjugated bile acid taurocholic acid. Plasma levels of 3-Sulfo-taurocholic Acid Disodium Salt are elevated in wild-type and Sortilin 1 (Sort1) knockout mice at 6 hours following bile duct ligation (BDL) and are further elevated in Sort1 knockout mice at 24 hours post-BDL.
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1 Cited Publications
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SORT-PGRN interaction inhibitor 1 is a potent inhibitor of the sortilin-progranulin interaction with an IC50 of 2 μM .
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Cat. No.: HY-N16308
CAS No.: 3091879-77-2
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Cat. No.: HY-D1581
CAS No.: 878674-84-1
Cat. No.: HY-P5481
CAS No.: 1807943-24-3
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BVFP binds to the PGRN588–593 peptide with a Kd of 20 μM. BVFP can disrupt PGRN-SORT1 binding. BVFP also inhibits SORT1-mediated rPGRN endocytosis .
Cat. No.: HY-P991011
CAS No.: 2923556-87-8
Synonyms: AL101; GSK-4527226
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Cat. No.: HY-D2170
Cat. No.: HY-132975
CAS No.: 2231405-64-2
PrDiAzK is a bifunctional amino acid. PrDiAzK can be site-selectively incorporated into proteins in both bacterial and mammalian cell culture. PrDiAzK can be used for proteome-wide incorporation via stochastic orthogonal recoding of translation (SORT) . PrDiAzK is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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Sortin1 is a vacuolar protein sorting inhibitor that targets carboxypeptidase Y (CPY). Sortin1 is a soluble and membrane vacuolar marker molecule in plants and yeast .
Cat. No.: HY-RS13575
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SORT1 Human Pre-designed siRNA Set A contains three designed siRNAs for SORT1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-153688
CAS No.: 2691846-87-2
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SORT-PGRN interaction inhibitor 3 (Compound 13) is a SORT-PGRN interaction inhibitor (IC50: 0.17 μM). SORT-PGRN interaction inhibitor 3 can be used for research of neurodegenerative diseases .
Cat. No.: HY-159878
CAS No.: 3031580-91-0
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SORT1-IN-5 (compound 3) is a blood-brain barrier permeable SORT1 inhibitor. SORT1-IN-5 is an MSOH salt with limited oral bioavailability .
Cat. No.: HY-159868
CAS No.: 2806762-69-4
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SORT1-IN-1 (compound 2) is a SORT1 inhibitor .
Cat. No.: HY-159875
CAS No.: 2854233-44-4
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SORT1-IN-2 (compound 6) is a SORT1 inhibitor .
Cat. No.: HY-159876
CAS No.: 2915675-56-6
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SORT1-IN-3 (compound 5) is a blood-brain barrier permeable SORT1 inhibitor .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
