1 Result for "

Sipeimine (Standard)

" in MedChemExpress (MCE) Product Catalog:
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1 Results for "Sipeimine (Standard)" in MCE Product Catalog:

Sipeimine (Standard)
Sipeimine (Standard)
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Cat. No.: HY-N0696R
CAS No.: 61825-98-7
Synonyms: Imperialine (Standard)
Category:  

Alkaloids Piperidine Alkaloids Liliaceae Plants Fritillaria ussuriensis Maxim.

Target:  

Reference Standards PI3K NF-κB Akt NOD-like Receptor (NLR) Pyroptosis Ferroptosis

Sipeimine (Standard) is the analytical standard of Sipeimine (HY-N0696R). Sipeimine (Imperialine) is an inhibitor targeting the PI3K/AKT/NF-κB pathway and NLRP3 inflammasome, which can competitively bind to PI3K and p65. Sipeimine inhibits PI3K/AKT phosphorylation, blocks NF-κB nuclear translocation and NLRP3 inflammasome activation. Sipeimine exerts anti-inflammatory activities, inhibits pyroptosis and ferroptosis, and protects the extracellular matrix. Sipeimine can reduce cartilage degradation and synovial inflammation in osteoarthritis and improve PM2.5-induced lung injury. Sipeimine is mainly used in the study of anti-inflammatory and degenerative diseases .
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