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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
48 Results for "
TMPRSS2
" in MedChemExpress (MCE) Product Catalog:
Products (48)
48 Results for "TMPRSS2" in MCE Product Catalog:
46
46 Publications Verification
Synonyms: Camostat mesilate; FOY305; FOY-S980
Target:
4
Research Areas:
Bromhexine hydrochloride is a potent and specific TMPRSS2 protease inhibitor with an IC50 of 0.75 μM. Bromhexine hydrochloride can prevent and manage SARS-CoV-2 infection. Bromhexine hydrochloride is an autophagy agonist. Bromhexine hydrochloride is a mucolytic cough suppressant and has the potential for a range of respiratory conditions [2] .
4
4 Cited Publications
AIM-100 is a potent and selective Ack1 inhibitor with an IC50 of 21.58 nM. AIM-100 also inhibits Tyr 267 phosphorylation. AIM-100 does not inhibits other kinases including PI3-kinase and AKT subfamily members. AIM-100 has an anticancer effect [2].
1
1 Cited Publications
Synonyms: 11-KDHT; 5α-Dihydro-11-keto testosterone
Target:
Research Areas:
11-Ketodihydrotestosterone (11-KDHT; 5α-Dihydro-11-keto testosterone) is an endogenous steroid and a metabolite of 11β-Hydroxyandrostenedione. 11-Ketodihydrotestosterone is an active androgen and is also a potent androgen receptor (AR) agonist with a Ki of 20.4 nM and an EC50 of 1.35 nM for human AR. 11-Ketodihydrotestosterone drives gene regulation, protein expression and cell growth in androgen-dependent prostate cancer cells [2].
1
1 Cited Publications
Cat. No.: HY-134432B
Purity: 99.69%
Target:
Research Areas:
1
1 Cited Publications
Cat. No.: HY-W749874
CAS No.: 97457-31-3
Target:
1
1 Cited Publications
Cat. No.: HY-P72043
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: Serine protease 10; PRSS10;
Species:
Source:
Target:
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ARD-69 is a PROTAC degrader based on the E3 ubiquitin ligase VHL and targeting the androgen receptor, which can induce androgen receptor (AR) protein degradation in AR-positive prostate cancer cells. ARD-69 inhibits AR-regulated gene expression, binds to the AR ligand binding domain at one end and binds to VHL at the other end, prompting AR to be recruited to the E3 ubiquitin ligase complex, triggering proteasome degradation, thereby inhibiting AR signaling pathways and downstream gene expression (such as PSA, TMPRSS2). ARD-69 can be used to study of castration-resistant prostate cancer (mCRPC) [2] .
MM3122 is a selective type II transmembrane serine protease (TMPRSS2) inhibitor with an IC50 value of 0.34 nM. MM3122 effectively blocks TMPRSS2, thereby inhibiting the entry of SARS-CoV-2 and MERS-CoV into human cells .
Target:
BC-11 hydrobromide is a selective TMPRSS2 inhibitor (TMPRSS2 is a key host cellular factor for viral entry and SARS-CoV-2 pathogenesis), and a selective urokinase (uPA) inhibitor (IC50=8.2 μM). BC-11 hydrobromide is cytotoxic to triple-negative MDA-MB231 breast cancer cells. BC-11 hydrobromide is used in research on viral infections and cancer [2] .
Cat. No.: HY-W195509
CAS No.: 1052540-65-4
Synonyms: Debrisoquine hydroiodide; Isocaramidine hydroiodide; Ro 5-3307/1 hydroiodide
Target:
Research Areas:
Debrisoquin (hydroiodide) is the hydrochloride form of Debrisoquin (HY-B1624). Debrisoquin is a TMPRSS2 inhibitors that inhibits SARS-CoV-2 entry into human lung cell line by a TMPRSS2-depedent manner. Debrisoquin can be used for antiviral research .
Synonyms: Debrisoquine hemisulfate; Isocaramidine hemisulfate; Ro 5-3307/1 hemisulfate
Target:
Cat. No.: HY-13512R
CAS No.: 59721-29-8
Synonyms: Camostat mesilate (Standard); FOY305 (Standard); FOY-S980 (Standard)
Target:
Research Areas:
Debrisoquin (Isocaramidine) is a TMPRSS2 inhibitors that inhibits SARS-CoV-2 entry into human lung cell line by a TMPRSS2-depedent manner, with an IC50 of 22μM. Debrisoquin can be used for antiviral research .
Cat. No.: HY-RS14769
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Research Areas:
TMPRSS2 Human Pre-designed siRNA Set A contains three designed siRNAs for TMPRSS2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS16739
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Tmprss2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Tmprss2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Propamidine is a covalent inhibitor of TMPRSS2 and has some antibacterial activity. .
Cat. No.: HY-P990524
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Research Areas:
Cat. No.: HY-134432A
CAS No.: 201849-55-0
Target:
Research Areas:
Boc-Gln-Ala-Arg-AMC hydrochloride is a fluorogenic substrate for trypsin. Boc-Gln-Ala-Arg-AMC hydrochloride can also be used for measuring the proteolytic activity of TMPRSS2 [2].
Cat. No.: HY-RS23176
Target:
Research Areas:
Tmprss2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Tmprss2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
