Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
49 Results for "
TMPRSS2
" in MedChemExpress (MCE) Product Catalog:
Products (49)
49 Results for "TMPRSS2" in MCE Product Catalog:
49
49 Publications Verification
Synonyms: Camostat mesilate; FOY305; FOY-S980
Target:
Áreas de investigación:
Camostat mesylate (Camostat mesilate) is an orally active, synthetic serine protease inhibitor for chronic pancreatitis. Camostat mesylate, an inhibitor of TMPRSS2, shows antiviral activity against SARS-CoV-2. Camostat mesylate also inhibits the activity of prostasin, trypsin, and matriptase [2] .
4
Áreas de investigación:
Bromhexine hydrochloride is a potent and specific TMPRSS2 protease inhibitor with an IC50 of 0.75 μM. Bromhexine hydrochloride can prevent and manage SARS-CoV-2 infection. Bromhexine hydrochloride is an autophagy agonist. Bromhexine hydrochloride is a mucolytic cough suppressant and has the potential for a range of respiratory conditions [2] .
1
1 Cited Publications
Referencia número: HY-134432B
Pureza: 99.69%
Target:
Áreas de investigación:
1
1 Cited Publications
Referencia número: HY-W749874
No. CAS: 97457-31-3
Category:
Acanthaceae Extract Plant Flavonoids Baphicacanthus cusia (Nees) Bremek. Extract Other Flavonoids
Target:
1
1 Cited Publications
Referencia número: HY-P72043
Pureza: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: TMPRSS2; Transmembrane Protease, Serine 2; Transmembrane Serine Protease 2; Serine Protease 10; PRSS10; Epitheliasin; Transmembrane Protease Serine 2
Species:
Human
Source:
P. pastoris
Target:
Áreas de investigación:
ARD-69 is a PROTAC degrader based on the E3 ubiquitin ligase VHL and targeting the androgen receptor, which can induce androgen receptor (AR) protein degradation in AR-positive prostate cancer cells. ARD-69 inhibits AR-regulated gene expression, binds to the AR ligand binding domain at one end and binds to VHL at the other end, prompting AR to be recruited to the E3 ubiquitin ligase complex, triggering proteasome degradation, thereby inhibiting AR signaling pathways and downstream gene expression (such as PSA, TMPRSS2). ARD-69 can be used to study of castration-resistant prostate cancer (mCRPC) [2] .
MM3122 is a selective type II transmembrane serine protease (TMPRSS2) inhibitor with an IC50 value of 0.34 nM. MM3122 effectively blocks TMPRSS2, thereby inhibiting the entry of SARS-CoV-2 and MERS-CoV into human cells .
Target:
BC-11 hydrobromide is a selective TMPRSS2 inhibitor (TMPRSS2 is a key host cellular factor for viral entry and SARS-CoV-2 pathogenesis), and a selective urokinase (uPA) inhibitor (IC50=8.2 μM). BC-11 hydrobromide is cytotoxic to triple-negative MDA-MB231 breast cancer cells. BC-11 hydrobromide is used in research on viral infections and cancer [2] .
Referencia número: HY-W195509
No. CAS: 1052540-65-4
Synonyms: Debrisoquine hydroiodide; Isocaramidine hydroiodide; Ro 5-3307/1 hydroiodide
Target:
Áreas de investigación:
Debrisoquin (hydroiodide) is the hydrochloride form of Debrisoquin (HY-B1624). Debrisoquin is a TMPRSS2 inhibitors that inhibits SARS-CoV-2 entry into human lung cell line by a TMPRSS2-depedent manner. Debrisoquin can be used for antiviral research .
Synonyms: Debrisoquine hemisulfate; Isocaramidine hemisulfate; Ro 5-3307/1 hemisulfate
Target:
Referencia número: HY-13512R
No. CAS: 59721-29-8
Synonyms: Camostat mesilate (Standard); FOY305 (Standard); FOY-S980 (Standard)
Referencia número: HY-RS14769
Target:
Áreas de investigación:
TMPRSS2 Human Pre-designed siRNA Set A contains three designed siRNAs for TMPRSS2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Referencia número: HY-RS16739
Target:
Áreas de investigación:
Tmprss2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Tmprss2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Target:
Áreas de investigación:
Debrisoquin (Isocaramidine) is a TMPRSS2 inhibitors that inhibits SARS-CoV-2 entry into human lung cell line by a TMPRSS2-depedent manner, with an IC50 of 22μM. Debrisoquin can be used for antiviral research .
Propamidine is a covalent inhibitor of TMPRSS2 and has some antibacterial activity. .
Referencia número: HY-RS23176
Target:
Áreas de investigación:
Tmprss2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Tmprss2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Referencia número: HY-P990524
Target:
Áreas de investigación:
Referencia número: HY-134432A
No. CAS: 201849-55-0
Target:
Áreas de investigación:
Boc-Gln-Ala-Arg-AMC hydrochloride is a fluorogenic substrate for trypsin. Boc-Gln-Ala-Arg-AMC hydrochloride can also be used for measuring the proteolytic activity of TMPRSS2 [2].
Referencia número: HY-158073
No. CAS: 2943213-62-3
ML2006a4 is an orally active inhibitor for SARS-CoV-2 main protease (M pro) with IC50 in picomolare value. ML2006a4 is cell permeable and antiviral active, that inhibits replication in SARS-CoV-2 in cells Huh7.5.1-ACE2-TMPRSS2 (Huh7.5.1++) in picomolare level
Referencia número: HY-B0372AS
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
