873305-35-2
873305-35-2
Chemical Structure
AIM-100
- CAS 番号: 873305-35-2
- Formula:C23H21N3O2
- Molecular Weight:371.43
IUPAC Name: (S)-5,6-diphenyl-N-((tetrahydrofuran-2-yl)methyl)furo[2,3-d]pyrimidin-4-amine
InChIKey: XNFHHOXCDUAYSR-SFHVURJKSA-N
SMILES: C1(C2=C(C3=CC=CC=C3)OC4=C2C(NC[C@@H]5CCCO5)=NC=N4)=CC=CC=C1
Biological Activity: AIM-100 is a potent and selective Ack1 inhibitor with an IC50 of 21.58 nM. AIM-100 also inhibits Tyr267 phosphorylation. AIM-100 does not inhibits other kinases including PI3-kinase and AKT subfamily members. AIM-100 has an anticancer effect[1][2].
| 製品番号 | 製品名 | 純度 | 製品説明 | Pricing | |||||||||||||||||||
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AIM-100 | 99.95% | AIM-100 is a potent and selective Ack1 inhibitor with an IC50 of 21.58 nM. AIM-100 also inhibits Tyr267 phosphorylation. AIM-100 does not inhibits other kinases including PI3-kinase and AKT subfamily members. AIM-100 has an anticancer effect. | ||||||||||||||||||||
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Structural Analogs
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Similarity Score 0.63
HY-18213EGFR-IN-9 -
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HY-148327AK-IN-1 -
Similarity Score 0.60
HY-128778Gozanertinib -
Similarity Score 0.49
HY-153554NLRP3-IN-18 -
Similarity Score 0.49
HY-125741GW768505A free base -
Similarity Score 0.48
HY-125035LCH-7749944 -
Similarity Score 0.48
HY-149848MMP-9-IN-6 -
Similarity Score 0.47
HY-171218CGP062464 -
Similarity Score 0.47
HY-W1599171,4-Di(5-Phenyl-2-oxazolyl)benzene -
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References
- [1]. Mahajan K, et al. Ack1 tyrosine kinase activation correlates with pancreatic cancer progression. Am J Pathol. 2012 Apr;180(4):1386-93. [Content Brief]
- [2]. Mahajan K, et al. Ack1-mediated androgen receptor phosphorylation modulates radiation resistance in castration-resistant prostate cancer. J Biol Chem. 2012 Jun 22;287(26):22112-22. [Content Brief]
