1. Protein Tyrosine Kinase/RTK
  2. VEGFR
  3. GW768505A free base

GW768505A free base 

Cat. No.: HY-125741
Handling Instructions

GW768505A free base is a potent dual inhibitor of VEGFR2 (KDR) and Tie-2, with a pIC50 of 7.81 for VEGFR2. GW768505A free base has anti-angiogenic activity。

For research use only. We do not sell to patients.

GW768505A free base Chemical Structure

GW768505A free base Chemical Structure

CAS No. : 501693-25-0

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Description

GW768505A free base is a potent dual inhibitor of VEGFR2 (KDR) and Tie-2, with a pIC50 of 7.81 for VEGFR2. GW768505A free base has anti-angiogenic activity[1]

IC50 & Target[1]

KDR

 

Tie-2

 

In Vitro

GW768505A free base has inhibition for cancer cells growth in NCI-60 panel screening[2].
GW768505A free base is an inhibitor of KDR and TIE2, shows potent inhibition (71–88% inhibition at 100 nM) of the tropomysin-related kinases TRKA, TRKB and TRKC[2].

Molecular Weight

537.47

Formula

C₂₇H₁₉F₄N₅O₃

CAS No.

501693-25-0

SMILES

O=C(NC1=CC(C(F)(F)F)=CC=C1F)NC2=CC=C(C3=C(C4=CC=C(OC)C=C4)OC5=NC=NC(N)=C53)C=C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

GW768505AVEGFRVascular endothelial growth factor receptorVEGFR2KDRanti-angiogenicInhibitorinhibitorinhibit

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GW768505A free base
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HY-125741
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