1. Protein Tyrosine Kinase/RTK
    JAK/STAT Signaling
  2. EGFR
  3. EGFR-IN-9

EGFR-IN-9 

Cat. No.: HY-18213
Handling Instructions

EGFR-IN-9 (Compound 8) is a potent EGFR kinase inhibitor with IC50s of 7 nM, 28 nM for the wild type EGFR kinase and double mutant EGFR kinase (L858R/T790M). EGFR-IN-9 has antitumor activity.

For research use only. We do not sell to patients.

EGFR-IN-9 Chemical Structure

EGFR-IN-9 Chemical Structure

CAS No. : 1226549-39-8

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Description

EGFR-IN-9 (Compound 8) is a potent EGFR kinase inhibitor with IC50s of 7 nM, 28 nM for the wild type EGFR kinase and double mutant EGFR kinase (L858R/T790M). EGFR-IN-9 has antitumor activity[1].

IC50 & Target[1]

EGFR (WT)

7 nM (IC50)

EGFRL858R/T790M

28 nM (IC50)

In Vitro

EGFR-IN-9 (Compound 8) shows antiproliferative activity in HCC827 lung cancer cell line with an IC50 of 8 nM.

Molecular Weight

476.53

Formula

C₂₉H₂₄N₄O₃

CAS No.

1226549-39-8

SMILES

C=CC(NC1=CC=CC(C2=C(C3=CC=CC=C3)OC4=NC=NC(N[[email protected]@H](C5=CC=CC=C5)CO)=C42)=C1)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

EGFR-IN-9EGFREpidermal growth factor receptorErbB-1HER1Inhibitorinhibitorinhibit

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