2 Results for "

Tyk2-IN-7

" in MedChemExpress (MCE) Product Catalog:
Products (2)

2 Results for "Tyk2-IN-7" in MCE Product Catalog:

Cat. No.: HY-126242S
CAS No.: 1609391-90-3
Purity:  99.62%
Tyk2-IN-7 is an orally active TYK2 JH2 inhibitor, binds to TYK2 JH2 domain with IC50 and Ki.app of 0.00053 μM and 0.00007 μM, respectively. Tyk2-IN-7 provides a highly selective alternative to conventional TYK2 orthosteric inhibitors, inhibits TYK2/JAK1/JAK2 kinase domain. Tyk2-IN-7 can inhibit the IL-23 and IFN-α signaling pathways. Tyk2-IN-7 is commonly used in the study of inflammatory conditions such as colitis .
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Cat. No.: HY-153702
CAS No.: 2673176-36-6
Target:  

JAK

Research Areas:  

Cancer

JAK-IN-27 (compound 1) is an orally active and potent JAKS family kinase inhibitor with IC50s of 3.0 nM (TYK2), 7.7 nM (JAK1), 629.6 nM (JAK3), respectively. JAK-IN-27 inhibits IFN-α2B-induced phosphorylation of STAT3 in Jurkat cells (IC50=23.7 nM) .
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