2673176-36-6
2673176-36-6
Chemical Structure
JAK-IN-27
- CAS No.: 2673176-36-6
- Formula:C20H21F2N7O
- Molecular Weight:413.42
InChIKey: QYCVEBICDFQYBS-ZNMIVQPWSA-N
SMILES: O=C([C@H](C1)C1(F)F)N2[C@H]3CN(C[C@@H]2CC3)C4=NC(C(C=N5)=CN5C)=CN6C4=CC=N6
Biological Activity: JAK-IN-27 (compound 1) is an orally active and potent JAKS family kinase inhibitor with IC50s of 3.0 nM (TYK2), 7.7 nM (JAK1), 629.6 nM (JAK3), respectively. JAK-IN-27 inhibits IFN-α2B-induced phosphorylation of STAT3 in Jurkat cells (IC50=23.7 nM)[1].
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JAK-IN-27 | JAK-IN-27 (compound 1) is an orally active and potent JAKS family kinase inhibitor with IC50s of 3.0 nM (TYK2), 7.7 nM (JAK1), 629.6 nM (JAK3), respectively. JAK-IN-27 inhibits IFN-α2B-induced phosphorylation of STAT3 in Jurkat cells (IC50=23.7 nM). | |||||||||||||||||||||
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References
Keywords
