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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
11 Results for "
V79 cells
" in MedChemExpress (MCE) Product Catalog:
Products (11)
11 Results for "V79 cells" in MCE Product Catalog:
5
Category:
2
2 Cited Publications
Target:
Research Areas:
7-Azido-4-methylcoumarin is a selective coumarin-based fluorescent probe for hydrogen sulfide (H2S). In the presence of H2S, the aromatic azido group of 7-Azido-4-methylcoumarin is selectively reduced to produce the fluorescently active 7-amino-4-methylcoumarin (AMC). 7-Azido-4-methylcoumarin binds to the coumarin/phenol-binding site of BSA, the aglycone-binding site of UGT1A6, and the substrate-binding site of SULT1A1, respectively. 7-Azido-4-methylcoumarin retains its fluorescent properties after covalent binding, acts as a fluorescent H2S probe, and does not react with cysteine, homocysteine or glutathione (Ex/Em = 340/445 nm) .
Cat. No.: HY-N2306A
CAS No.: 75443-99-1
Synonyms: Aclarubicin hydrochloride
Cat. No.: HY-W008581
CAS No.: 1035-77-4
Synonyms: 3-O-Methyl estradiol; 17β-Estradiol 3-methyl ether; 3-Methoxyestradiol
Research Areas:
Estradiol 3-methyl ether (EDME) is a highly selective TRPML1 ion channel antagonist and microtubule (microtubule) depolymerizing agent, with IC50 values of 0.22 μM and 3.8 μM against TRPML1 and TRPML2, respectively; it shows no activity against TRPML3. Estradiol 3-methyl ether induces the disruption of cytoplasmic microtubule networks in mammalian cells, with an EC50 of 9 μM. Independent of estrogen receptors, Estradiol 3-methyl ether blocks autophagy (autophagy), TFEB nuclear translocation, and inhibits the migration and invasion of triple-negative breast cancer cells by suppressing TRPML1. Estradiol 3-methyl ether is applicable for relevant research on triple-negative breast cancer .
Cat. No.: HY-N2306R
CAS No.: 57576-44-0
Synonyms: Aclarubicin (Standard)
Category:
Cat. No.: HY-121648
CAS No.: 140448-29-9
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Research Areas:
PK 130 is a 2-nitroimidazole derivative that has radiosensitizing effects on hypoxic cells. PK 130 increases the radiosensitivity of Chinese hamster V79 cells under hypoxic conditions .
Cat. No.: HY-D1749
CAS No.: 114301-96-1
Cat. No.: HY-N0025
CAS No.: 120406-34-0
Cat. No.: HY-187015
CAS No.: 74141-74-5
Synonyms: NSC 314055
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Research Areas:
SR-2555 (NSC 314055) is a CYP2D6 inhibitor with an IC50 of 1017 μM against human CYP2D6. SR-2555 inhibits the AMMC demethylase activity of recombinant CYP2D6; differentially enhances the sensitivity of hypoxic cells to the lethal effect of γ-rays; and exhibits cytotoxicity against hypoxic cells. SR-2555 can be used in cancer-related research .
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Oxymethurea (Dimethylolurea) is a formaldehyde-releasing protein modification reagent. Under acidic conditions, Oxymethurea promotes nucleophilic substitution of tyrosine via protonation of its hydroxymethyl group, while under alkaline conditions, it promotes protein crosslinking by converting the phenolic hydroxyl group of tyrosine into a more nucleophilic phenoxide ion. Oxymethurea can be used in studies related to protein chemical modification, protein crosslinking, protein protection and genotoxicity .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
