74141-74-5
Chemical Structure
SR-2555
Synonym(s): NSC 314055
- CAS No.: 74141-74-5
- Formula:C9H14N4O5
- Molecular Weight:258.23
IUPAC Name: N,N-bis(2-hydroxyethyl)-2-(2-nitro-1H-imidazol-1-yl)acetamide
InChIKey: KGFGBSRVWKBWIC-UHFFFAOYSA-N
SMILES: O=C(N(CCO)CCO)CN1C=CN=C1[N+]([O-])=O
Biological Activity: SR-2555 (NSC 314055) is a CYP2D6 inhibitor with an IC50 of 1017 μM against human CYP2D6. SR-2555 inhibits the AMMC demethylase activity of recombinant CYP2D6; differentially enhances the sensitivity of hypoxic cells to the lethal effect of γ-rays; and exhibits cytotoxicity against hypoxic cells. SR-2555 can be used in cancer-related research[1][2].
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SR-2555 | SR-2555 (NSC 314055) is a CYP2D6 inhibitor with an IC50 of 1017 μM against human CYP2D6. SR-2555 inhibits the AMMC demethylase activity of recombinant CYP2D6; differentially enhances the sensitivity of hypoxic cells to the lethal effect of γ-rays; and exhibits cytotoxicity against hypoxic cells. SR-2555 can be used in cancer-related research. | |||||||||||||||||||||
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[1]. Kemp C A, et al. Validation of Model of Cytochrome P450 2D6: An in Silico Tool for Predicting Metabolism and Inhibition. J. Med. Chem, 2004, 47(22): 5340-5346.
- [2]. Astor M, et al. Newly synthesized hypoxia-mediated drugs as radiosensitizers and cytotoxic agents. International journal of radiation oncology, biology, physics. 1982 Jan;8(1):75-83. [Content Brief]
Keywords
