140-95-4
Chemical Structure
Oxymethurea
Synonym(s): Dimethylolurea
- No. CAS: 140-95-4
- Formula:C3H8N2O3
- Molecular Weight:120.11
IUPAC Name: 1,3-bis(hydroxymethyl)urea
InChIKey: QUBQYFYWUJJAAK-UHFFFAOYSA-N
SMILES: O=C(NCO)NCO
Biological Activity: Oxymethurea (Dimethylolurea) is a formaldehyde-releasing protein modification reagent. Under acidic conditions, Oxymethurea promotes nucleophilic substitution of tyrosine via protonation of its hydroxymethyl group, while under alkaline conditions, it promotes protein crosslinking by converting the phenolic hydroxyl group of tyrosine into a more nucleophilic phenoxide ion. Oxymethurea can be used in studies related to protein chemical modification, protein crosslinking, protein protection and genotoxicity[1][2][3].
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Oxymethurea | Oxymethurea (Dimethylolurea) is a formaldehyde-releasing protein modification reagent. Under acidic conditions, Oxymethurea promotes nucleophilic substitution of tyrosine via protonation of its hydroxymethyl group, while under alkaline conditions, it promotes protein crosslinking by converting the phenolic hydroxyl group of tyrosine into a more nucleophilic phenoxide ion. Oxymethurea can be used in studies related to protein chemical modification, protein crosslinking, protein protection and genotoxicity. | |||||||||||||||||||||
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- [1]. White AC, et al. A multiple in silico program approach for the prediction of mutagenicity from chemical structure. Mutation research. 2003 Aug 05;539(1-2):77-89. [Content Brief]
- [2]. Friedman M, et al. Dimethylolurea as a Tyrosine Reagent and Protein Protectant against Ruminal Degradation. Journal of Agricultural and Food Chemistry. 1982;30:72-77.
- [3]. Pfuhler S, et al. Effects of the formaldehyde releasing preservatives dimethylol urea and diazolidinyl urea in several short-term genotoxicity tests. Mutation research. 2002 Feb 15;514(1-2):133-46. [Content Brief]
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