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Results for "

VL

" in MedChemExpress (MCE) Product Catalog:

21

Inhibitors & Agonists

1

Peptides

3

Inhibitory Antibodies

2

Antibodies

3

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-W077028
    N-(2-Hydroxypropyl)methacrylamide

    		Biochemical Assay Reagents Others
    N-(2-Hydroxypropyl)methacrylamide is used to synthesize copolymers for the targeted delivery of antileishmanial agents in Visceral leishmaniasis (VL) .
    N-(2-Hydroxypropyl)methacrylamide
  • HY-111663
    VL285

    		Ligands for E3 Ligase Cancer
    VL285 is a potent VHL ligand with an IC50 of 0.34 μM .
    VL285
  • HY-131350
    LXE408

    		Proteasome Parasite Infection
    LXE408 is an orally active, non-competitive and kinetoplastid-selective proteasome inhibitor. LXE408 has an IC50 of 0.04 μM for L. donovani proteasome and an EC50 of 0.04 μM for L. donovani. LXE408 has a low propensity to cross the blood brain barrier. LXE408 has the potential for visceral leishmaniasis (VL) research .
    LXE408
  • HY-159709
    VL-422

    		Liposome Metabolic Disease
    VL-422 is an ionizable cationic lipid. VL-422 delivers CRISPR complementary single-guide RNA (sgRNA) and Cas9 mRNA to enable in vitro and in vivo gene editing. LNPs containing VL-422 loaded with Cas9 mRNA and sgRNA targeting the ANGPTL3 gene induce the deletion of premature stop codons within the ANGPTL3 gene in the liver of cynomolgus monkeys. Loss-of-function of ANGPTL3 leads to decreased levels of LDL, HDL and cholesterol in plasma. The VL-422 delivery system can be used for the research of gene editing strategies targeting lipid metabolism diseases .
    VL-422
  • HY-151227
    VL285 Phenol

    		Ligands for E3 Ligase Cancer
    VL285 Phenol is a phenol-based VL285 analog. VL285 is an E3 ubiquitin ligase VHL ligand and can be used in the synthesis of HaloPROTAC3, degrading HaloTag7 fusion protein (IC50=0.34 μM).
    VL285 Phenol
  • HY-W086630
    Camphorquinone

    2,3-Bornanedione

    		 Biochemical Assay Reagents Others
    Camphorquinone (2,3-Bornanedione) is a photoinitiator. Camphorquinone enhances free radical production under visible light (VL) irradiation and exhibits minimal cytotoxicity to HPF cells. Camphorquinone is used in the research of dental resin polymers .
    Camphorquinone
  • HY-156132
    DNDI-0690

    		Parasite Infection
    DNDI-0690 is a potent orally active analogue of DNDI-VL-2098, exhibiting potent activity against cutaneous leishmaniasis (CL). DNDI-0690 shows potent in vitro activity against CL-causing Leishmania species (EC50 = 0.17 μM against visceral leishmaniasis (VL), and < 5 μM against CL-causing species). DNDI-0690 exerts effects in a mouse model of L. major CL. DNDI-0690 can be used for CL research .
    DNDI-0690
  • HY-145033
    VL-6

    		Biochemical Assay Reagents Others
    VL-6 can be used in the synthesis of biomimetic nanomaterials which for delivery of therapeutic, diagnostic, or prophylactic agents .
    VL-6
  • HY-118904
    VL-0395

    		Cholecystokinin Receptor Metabolic Disease
    VL-0395 is a CCK1 selective antagonist with IC50 of 0.197 μM for CCK1 in rat pancreatic acinar cells .
    VL-0395
  • HY-P990810
    Anti-LCMV Nucleoprotein Antibody (VL-4)

    		Arenavirus Infection
    Anti-LCMV Nucleoprotein Antibody (VL-4) is rat-derived IgG2a κ type antibody inhibitor, targeting to LCMV nucleoprotein. Anti-LCMV Nucleoprotein Antibody (VL-4) reacts with lymphocytic choriomeningitis virus (LCMV) nucleoprotein. Anti-LCMV Nucleoprotein Antibody (VL-4) stain LCMV-infected cell internally with no surface staining. Anti-LCMV Nucleoprotein Antibody (VL-4) can be used for the detections of immunohistochemistry and flow cytometry in LCMV infection .
    Anti-LCMV Nucleoprotein Antibody (VL-4)
  • HY-169088
    VL285 Phenol-PEG2-Cl

    		E3 Ligase Ligand-Linker Conjugates Cancer
    VL285 Phenol-PEG2-Cl is the conjugate of E3 Ligase ligand and PROTAC Linker, whcich can be used to synthesize PROTACs, such as MS41 (HY-169086).
    VL285 Phenol-PEG2-Cl
  • HY-W077028R
    N-(2-Hydroxypropyl)methacrylamide (Standard)

    		Biochemical Assay Reagents Reference Standards Others
    N-(2-Hydroxypropyl)methacrylamide is used to synthesize copolymers for the targeted delivery of antileishmanial agents in Visceral leishmaniasis (VL) .
    N-(2-Hydroxypropyl)methacrylamide (Standard)
  • HY-178456
    Antileishmanial agent-36

    		Parasite Reactive Oxygen Species (ROS) Apoptosis Infection
    Antileishmanial agent-36 (compound 4f) is an indole-dihydropyrimidinone derivative with anti-leishmanial activity. Antileishmanial agent-36 induces reactive oxygen species (ROS)-mediated mitochondrial dysfunction and apoptosis. Antileishmanial agent-36 exhibits potent activity against L. donovani (IC50 =4.54 μM) with low cytotoxicity against J774.1 macrophage. Antileishmanial agent-36 clears the parasite burden in a visceral leishmaniasis (VL) model. Antileishmanial agent-36 can be used for VL research .
    Antileishmanial agent-36
  • HY-RS19508
    Gpr161 Mouse Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Gpr161 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Gpr161 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Gpr161 Mouse Pre-designed siRNA Set A
    Gpr161 Mouse Pre-designed siRNA Set A
  • HY-RS08485
    MLC1 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    MLC1 Human Pre-designed siRNA Set A contains three designed siRNAs for MLC1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    MLC1 Human Pre-designed siRNA Set A
    MLC1 Human Pre-designed siRNA Set A
  • HY-151395
    Tubulin polymerization-IN-34

    		Microtubule/Tubulin Cancer
    Tubulin polymerization-IN-34 is an inhibitor of [1,2]oxazoloisoindoles tubulin polymerization, demonstrates high selectivity against marginal zone lymphoma VL51 cell line .
    Tubulin polymerization-IN-34
  • HY-151396
    Tubulin polymerization-IN-35

    		Microtubule/Tubulin Cancer
    Tubulin polymerization-IN-35 is an inhibitor of [1,2]oxazoloisoindoles tubulin polymerization, demonstrates high selectivity against marginal zone lymphoma VL51 cell line .
    Tubulin polymerization-IN-35
  • HY-131350A
    LXE408 fumarate

    		Proteasome Parasite Infection
    LXE408 fumarate is an orally active, non-competitive and kinetoplastid-selective proteasome inhibitor. LXE408 fumarate has an IC50 of 0.04 μM for L. donovani proteasome and an EC50 of 0.04 μM for L. donovani. LXE408 fumarate has a low propensity to cross the blood brain barrier. LXE408 fumarate has the potential for visceral leishmaniasis (VL) research .
    LXE408 fumarate
  • HY-175364
    Antiparasitic agent-27

    		Parasite Reactive Oxygen Species (ROS) Infection
    Antiparasitic agent-27 (Compound 2) is a potent antiparasitic agent targeting Leishmania infantum (IC50=3.1 μM). Antiparasitic agent-27 induces G0/G1 cell cycle arrest and reactive oxygen species (ROS) generation to trigger programmed cell death. Antiparasitic agent-27 is promising for research of visceral leishmaniasis (VL) .
    Antiparasitic agent-27
  • HY-W663179
    DNDI-VL-2098

    		Parasite Cytochrome P450 Infection
    DNDI-VL-2098 is an orally active antileishmanial agent. DNDI-VL-2098 exhibits high permeability, in vitro metabolic stability, and selective inhibition of CYP2C19 (IC50=0.47 μM). DNDI-VL-2098 does not affect the activities of other major CYP enzymes (CYP1A2, CYP2C9, CYP2D6 and CYP3A4) at concentrations up to 12.5 μM. It shows favorable pharmacokinetic properties in multiple animal models including mice, hamsters, rats and dogs. DNDI-VL-2098 is characterized by moderate to high plasma protein binding and can be used for the research of visceral leishmaniasis .
    DNDI-VL-2098
  • HY-P992232
    Anti-GFRA4 Antibody (scFv)

    		RET Inflammation/Immunology
    Anti-GFRA4 Antibody (scFv) is a recombinant single-chain antibody fragment targeting GFRA4. Anti-GFRA4 Antibody (scFv) is formed by connecting the variable region of the heavy chain (VH) and the variable region of the light chain (VL) through a flexible short peptide (Linker), without the Fc segment, while maintaining the antigen-binding specificity.
    Anti-GFRA4 Antibody (scFv)

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