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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
25 Results for "
VL
" in MedChemExpress (MCE) Product Catalog:
Products (25)
25 Results for "VL" in MCE Product Catalog:
Cat. No.: HY-W077028
CAS No.: 21442-01-3
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N-(2-Hydroxypropyl)methacrylamide is used to synthesize copolymers for the targeted delivery of antileishmanial agents in Visceral leishmaniasis (VL) .
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VL285 is a potent VHL ligand with an IC50 of 0.34 μM .
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LXE408 is an orally active, non-competitive and kinetoplastid-selective proteasome inhibitor. LXE408 has an IC50 of 0.04 μM for L. donovani proteasome and an EC50 of 0.04 μM for L. donovani. LXE408 has a low propensity to cross the blood brain barrier. LXE408 has the potential for visceral leishmaniasis (VL) research .
Cat. No.: HY-159709
CAS No.: 2765519-47-7
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VL-422 is an ionizable cationic lipid. VL-422 delivers CRISPR complementary single-guide RNA (sgRNA) and Cas9 mRNA to enable in vitro and in vivo gene editing. LNPs containing VL-422 loaded with Cas9 mRNA and sgRNA targeting the ANGPTL3 gene induce the deletion of premature stop codons within the ANGPTL3 gene in the liver of cynomolgus monkeys. Loss-of-function of ANGPTL3 leads to decreased levels of LDL, HDL and cholesterol in plasma. The VL-422 delivery system can be used for the research of gene editing strategies targeting lipid metabolism diseases .
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VL285 Phenol is a phenol-based VL285 analog. VL285 is an E3 ubiquitin ligase VHL ligand and can be used in the synthesis of HaloPROTAC3, degrading HaloTag7 fusion protein (IC50=0.34 μM).
Cat. No.: HY-W086630
CAS No.: 10373-78-1
Synonyms: 2,3-Bornanedione
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Camphorquinone (2,3-Bornanedione) is a photoinitiator. Camphorquinone enhances free radical production under visible light (VL) irradiation and exhibits minimal cytotoxicity to HPF cells. Camphorquinone is used in the research of dental resin polymers .
Cat. No.: HY-156132
CAS No.: 2097881-13-3
Cat. No.: HY-P990162
Synonyms: AB1-2
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Cat. No.: HY-145033
CAS No.: 2274813-29-3
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VL-6 can be used in the synthesis of biomimetic nanomaterials which for delivery of therapeutic, diagnostic, or prophylactic agents .
Cat. No.: HY-118904
CAS No.: 620167-11-5
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VL-0395 is a CCK1 selective antagonist with IC50 of 0.197 μM for CCK1 in rat pancreatic acinar cells .
Cat. No.: HY-P990810
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Cat. No.: HY-169088
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VL285 Phenol-PEG2-Cl is the conjugate of E3 Ligase ligand and PROTAC Linker, whcich can be used to synthesize PROTACs, such as MS41 (HY-169086).
Cat. No.: HY-W077028R
CAS No.: 21442-01-3
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N-(2-Hydroxypropyl)methacrylamide is used to synthesize copolymers for the targeted delivery of antileishmanial agents in Visceral leishmaniasis (VL) .
Cat. No.: HY-178456
CAS No.: 3086122-36-0
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Antileishmanial agent-36 (compound 4f) is an indole-dihydropyrimidinone derivative with anti-leishmanial activity. Antileishmanial agent-36 induces reactive oxygen species (ROS)-mediated mitochondrial dysfunction and apoptosis. Antileishmanial agent-36 exhibits potent activity against L. donovani (IC50 =4.54 μM) with low cytotoxicity against J774.1 macrophage. Antileishmanial agent-36 clears the parasite burden in a visceral leishmaniasis (VL) model. Antileishmanial agent-36 can be used for VL research .
Cat. No.: HY-RS08485
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MLC1 Human Pre-designed siRNA Set A contains three designed siRNAs for MLC1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS19508
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Gpr161 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Gpr161 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-151395
CAS No.: 3051788-87-2
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Tubulin polymerization-IN-34 is an inhibitor of [1,2]oxazoloisoindoles tubulin polymerization, demonstrates high selectivity against marginal zone lymphoma VL51 cell line .
Cat. No.: HY-151396
CAS No.: 3051788-88-3
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Tubulin polymerization-IN-35 is an inhibitor of [1,2]oxazoloisoindoles tubulin polymerization, demonstrates high selectivity against marginal zone lymphoma VL51 cell line .
Cat. No.: HY-131350A
CAS No.: 3026790-19-9
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LXE408 fumarate is an orally active, non-competitive and kinetoplastid-selective proteasome inhibitor. LXE408 fumarate has an IC50 of 0.04 μM for L. donovani proteasome and an EC50 of 0.04 μM for L. donovani. LXE408 fumarate has a low propensity to cross the blood brain barrier. LXE408 fumarate has the potential for visceral leishmaniasis (VL) research .
Cat. No.: HY-175364
CAS No.: 3048504-54-4
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Antiparasitic agent-27 (Compound 2) is a potent antiparasitic agent targeting Leishmania infantum (IC50=3.1 μM). Antiparasitic agent-27 induces G0/G1 cell cycle arrest and reactive oxygen species (ROS) generation to trigger programmed cell death. Antiparasitic agent-27 is promising for research of visceral leishmaniasis (VL) .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
