DNDI-0690
DNDI-0690 is a potent orally active analogue of DNDI-VL-2098, exhibiting potent activity against cutaneous leishmaniasis (CL). DNDI-0690 shows potent in vitro activity against CL-causing Leishmania species (EC50 = 0.17 μM against visceral leishmaniasis (VL), and < 5 μM against CL-causing species). DNDI-0690 exerts effects in a mouse model of L. major CL. DNDI-0690 can be used for CL research.
For research use only. We do not sell to patients.
- CAS No.: 2097881-13-3
- Formula: C18H15FN4O4
- Molecular Weight:370.33
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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- References
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Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MRC5 | IC50 |
>64 μM
Compound: 79
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Cytotoxicity against human MRC5 cells assessed as cell viability after 72 hrs by resazurin assay
Cytotoxicity against human MRC5 cells assessed as cell viability after 72 hrs by resazurin assay
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[PMID: 28459575] |
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 2097881-13-3
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Molecular Weight 370.33
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Formula C18H15FN4O4
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SMILES
FC(C=C1)=CC=C1C2=NC=C(C=C2)OC[C@@H]3OC4=NC([N+]([O-])=O)=CN4CC3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
DNDI-0690 Related Classifications
HY-156132 Related Classifications
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