2097881-13-3
Chemical Structure
DNDI-0690
- CAS No.: 2097881-13-3
- Formula:C18H15FN4O4
- Molecular Weight:370.33
InChIKey: USIKCXQLXHGVDD-OAHLLOKOSA-N
SMILES: FC(C=C1)=CC=C1C2=NC=C(C=C2)OC[C@@H]3OC4=NC([N+]([O-])=O)=CN4CC3
Biological Activity: DNDI-0690 is a potent orally active analogue of DNDI-VL-2098, exhibiting potent activity against cutaneous leishmaniasis (CL). DNDI-0690 shows potent in vitro activity against CL-causing Leishmania species (EC50 = 0.17 μM against visceral leishmaniasis (VL), and < 5 μM against CL-causing species). DNDI-0690 exerts effects in a mouse model of L. major CL. DNDI-0690 can be used for CL research[1].
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DNDI-0690 | DNDI-0690 is a potent orally active analogue of DNDI-VL-2098, exhibiting potent activity against cutaneous leishmaniasis (CL). DNDI-0690 shows potent in vitro activity against CL-causing Leishmania species (EC50 = 0.17 μM against visceral leishmaniasis (VL), and < 5 μM against CL-causing species). DNDI-0690 exerts effects in a mouse model of L. major CL. DNDI-0690 can be used for CL research. | |||||||||||||||||||||
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Keywords
