1448188-69-9
1448188-69-9
Chemical Structure
VL285 Phenol
- CAS No.: 1448188-69-9
- Formula:C29H32N4O5S
- Molecular Weight:548.65
IUPAC Name: (2S,4R)-4-hydroxy-N-(2-hydroxy-4-(4-methylthiazol-5-yl)benzyl)-1-((S)-3-methyl-2-(1-oxoisoindolin-2-yl)butanoyl)pyrrolidine-2-carboxamide
InChIKey: KNZQRBRUYSXXRG-VTZPFEBOSA-N
SMILES: CC(N=CS1)=C1C2=CC(O)=C(CNC([C@@H]3C[C@@H](O)CN3C([C@@H](N4CC(C=CC=C5)=C5C4=O)C(C)C)=O)=O)C=C2
Biological Activity: VL285 Phenol is a phenol-based VL285 analog. VL285 is an E3 ubiquitin ligase VHL ligand and can be used in the synthesis of HaloPROTAC3, degrading HaloTag7 fusion protein (IC50=0.34 μM).
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VL285 Phenol | VL285 Phenol is a phenol-based VL285 analog. VL285 is an E3 ubiquitin ligase VHL ligand and can be used in the synthesis of HaloPROTAC3, degrading HaloTag7 fusion protein (IC50=0.34 μM). | |||||||||||||||||||||
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