1 Result for "

Zederone

" in MedChemExpress (MCE) Product Catalog:
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1 Results for "Zederone" in MCE Product Catalog:

Zederone
Zederone
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Cat. No.: HY-N1050
CAS No.: 7727-79-9
Category:  

Terpenoids Sesquiterpenes Plants Curcuma elata Roxb. Zingiberaceae

Target:  

mTOR Ribosomal S6 Kinase (RSK) Bacterial

Zederone is a sesquiterpene. Zederone inhibits ovarian cancer cell proliferation through mTOR/p70s6K signalling pathway. Zederone inhibits CYP activities with IC50s of 2.9 μM (CYP2B6), 9.2 μM (CYP2C9), 11,2 μM (CYP2C19) and >30 μM (CYP1A2 and CYP2D6). Zederone is hepatotoxic with LD50 value at 24 hours in mice of approximately 223 mg/kg and cytotoxic against the KG1a cell line. Zederone shows antibacterial activity against a number of multi-drug resistant and Methicillin (HY-121544)-resistant Staphylococcus aureus strain. Zederone shows cognition improving capacity and assists in the modulation of gut bacterial dysbiosis .
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