7727-79-9
Chemical Structure
Zederone
- CAS No.: 7727-79-9
- Formula:C15H18O3
- Molecular Weight:246.30
IUPAC Name: (1aR,10aR,E)-1a,5,9-trimethyl-2,3,6,10a-tetrahydrooxireno[2',3':4,5]cyclodeca[1,2-b]furan-10(1aH)-one
InChIKey: CVIVANCKIBYAOP-KOMYPQRHSA-N
SMILES: CC1=COC(C/C(C)=C/CC[C@]2(C)[C@@]3([H])O2)=C1C3=O
Biological Activity: Zederone is a sesquiterpene. Zederone inhibits ovarian cancer cell proliferation through mTOR/p70s6K signalling pathway. Zederone inhibits CYP activities with IC50s of 2.9 μM (CYP2B6), 9.2 μM (CYP2C9), 11,2 μM (CYP2C19) and >30 μM (CYP1A2 and CYP2D6). Zederone is hepatotoxic with LD50 value at 24 hours in mice of approximately 223 mg/kg and cytotoxic against the KG1a cell line. Zederone shows antibacterial activity against a number of multi-drug resistant and Methicillin (HY-121544)-resistant Staphylococcus aureus strain. Zederone shows cognition improving capacity and assists in the modulation of gut bacterial dysbiosis[1][2][3][4][5][6].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Zederone | 99.61% | Zederone is a sesquiterpene. Zederone inhibits ovarian cancer cell proliferation through mTOR/p70s6K signalling pathway. Zederone inhibits CYP activities with IC50s of 2.9 μM (CYP2B6), 9.2 μM (CYP2C9), 11,2 μM (CYP2C19) and >30 μM (CYP1A2 and CYP2D6). Zederone is hepatotoxic with LD50 value at 24 hours in mice of approximately 223 mg/kg and cytotoxic against the KG1a cell line. Zederone shows antibacterial activity against a number of multi-drug resistant and Methicillin (HY-121544)-resistant Staphylococcus aureus strain. Zederone shows cognition improving capacity and assists in the modulation of gut bacterial dysbiosis. | ||||||||||||||||||||
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References
- [1]. Prapapan Pimkaew, et al. Zederone, a sesquiterpene from Curcuma elata Roxb, is hepatotoxic in mice. Int J Toxicol. 2013 Nov-Dec;32(6):454-62. [Content Brief]
- [2]. Zhilei Zhang, et al. A study of zederone for the inhibition on ovarian cancer cell proliferation through mTOR/p70s6K signalling pathway. J BUON. 2020 Mar-Apr;25(2):785-791. [Content Brief]
- [3]. Pimkaew P, et al. Interactions of sesquiterpenes zederone and germacrone with the human cytochrome P450 system. Toxicol In Vitro. 2013 Sep;27(6):2005-12. [Content Brief]
- [4]. Kader M G, et al. Zederone from the rhizomes of Zingiber zerumbet and its anti-staphylococcal activity[J]. Boletín Latinoamericano y del Caribe de Plantas Medicinales y Aromáticas, 2010, 9(1): 63-68.
- [5]. Anuchapreeda S, et al. Characterization and biological properties of zederone and zedoarondiol from rhizomes of En-lueang (Curcuma cf. Amada)[J]. Natural Product Communications, 2018, 13(12).
- [6]. Borah S, Sarkar P, Sharma HK. Zederone Improves the Fecal Microbial Profile in Dementia Induced Rat Model: A First Report. CNS Neurol Disord Drug Targets. 2022;21(4):335-342. [Content Brief]
