1. Apoptosis
  2. Apoptosis
  3. Linderalactone

Linderalactone 

Cat. No.: HY-N0781
Handling Instructions

Linderalactone is an important sesquiterpene lactone isolated from Radix linderae. Linderalactone inhibits cancer growth by modulating the expression of apoptosis-related proteins and inhibition of JAK/STAT signalling pathway. Linderalactone also inhibits the proliferation of the lung cancer A-549 cells with an IC50 of 15 µM.

For research use only. We do not sell to patients.

Linderalactone Chemical Structure

Linderalactone Chemical Structure

CAS No. : 728-61-0

Size Price Stock
1 mg USD 67 Ask For Quote & Lead Time
5 mg USD 202 Ask For Quote & Lead Time
10 mg USD 343 Ask For Quote & Lead Time

* Please select Quantity before adding items.

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Linderalactone is an important sesquiterpene lactone isolated from Radix linderae. Linderalactone inhibits cancer growth by modulating the expression of apoptosis-related proteins and inhibition of JAK/STAT signalling pathway. Linderalactone also inhibits the proliferation of the lung cancer A-549 cells with an IC50 of 15 µM[1][2].

In Vitro

Linderalactone (0-100 μM; 24 hours; A549 cells) treatment inhibits the growth of A549 cells concentration-dependently. The IC50 of linderalactone is 15 µM[1].
Linderalactone (7.5-30 μM; A549 cells) treatment induces apoptosis in A549 cells in a dose-dependent manner[1].
Linderalactone (7.5-30 μM; 24 hours; A549 cells) treatment induces G2/M cell cycle arrest of A549 cells dose-dependently[1].
Linderalactone (7.5-30 μM; A549 cells) inhibits the expression of STAT1, JAK1 and JAK2. Linderalactone could also inhibit the phosphorylation of pSTAT1, pSTAT-2, pJAK1 and pJAk2[1].

Cell Viability Assay[1]

Cell Line: Lung cancer A549 cells
Concentration: 0 μM, 1.6 μM, 3.2 μM, 6.25 μM, 12.5 μM, 25 μM, 50 μM, 100 μM
Incubation Time: 24 hours
Result: Inhibited the growth of A549 cells concentration-dependently.

Apoptosis Analysis[1]

Cell Line: Lung cancer A549 cells
Concentration: 7.5 μM, 15 μM, 30 μM
Incubation Time:
Result: Induced apoptosis in A549 cells in a dose-dependent manner.

Cell Cycle Analysis[1]

Cell Line: Lung cancer A549 cells
Concentration: 7.5 μM, 15 μM, 30 μM
Incubation Time: 24 hours
Result: Induced G2/M cell cycle arrest.

Western Blot Analysis[1]

Cell Line: Lung cancer A549 cells
Concentration: 7.5 μM, 15 μM, 30 μM
Incubation Time:
Result: Inhibited the JAK/STAT pathway in A549 cells.
Molecular Weight

244.29

Formula

C₁₅H₁₆O₃

CAS No.

728-61-0

SMILES

O=C1C2=C[[email protected]@](C3=C(OC=C3C)C/C(C)=C/CC2)([H])O1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

LinderalactoneApoptosisInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product name

 

Salutation

Applicant name *

 

Email address *

Phone number *

 

Organization name *

Country or Region *

 

Requested quantity *

Remarks

Bulk Inquiry

Inquiry Information

Product name:
Linderalactone
Cat. No.:
HY-N0781
Quantity:
MCE Japan Authorized Agent: