1. Apoptosis
  2. Apoptosis
  3. Furanodienone

Furanodienone 

Cat. No.: HY-N2184
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Furanodienone is one of the major bioactive constituents derived from Rhizoma Curcumae. Furanodienone induced apoptosis.

For research use only. We do not sell to patients.

Furanodienone Chemical Structure

Furanodienone Chemical Structure

CAS No. : 24268-41-5

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Description

Furanodienone is one of the major bioactive constituents derived from Rhizoma Curcumae. Furanodienone induced apoptosis[1].

In Vitro

Furanodienone (0-573.8 μM; 24  hours) exhibits IC50 values : 56.4 μM (RKO), 73.7 μM (sw480), 251.1 μM (HT-29), 412.5 μM (sw620) and 573.8 μM (LoVo) at 24 hours, while that in 48 h are 51.8 μM (RKO), 44.18 μM (sw480), 168.9 μM (HT-29), 314.2 μM (sw620) and 502.1 μM (LoVo), respectively[1].
Furanodienone (0-150 μM; 24  hours) induces apoptosis and shows increase in caspase-9 and -3 activity has been observed in both cells, whereas a relative minor effect on that of caspase-8 in RKO and HT-29 cells[1].
Furanodienone (0-150 μM; 24  hours) increases the apoptotic rates from 2.34±0.45% to 19.45±2.37% and 27.34±0.79%, in RKO cells at 75 and 150 μM. whereas 12.4±1.08 and 20.64±3.02% apoptosis at the concentration of 75 and 150 μM are observed in HT-29 cells compared with 2.89±0.26%[1].

Western Blot Analysis[1]

Cell Line: RKO and HT-29 cells
Concentration: 0 μM; 50 μM; 100 μM; 150 μM
Incubation Time: 24 hours
Result: Increased caspase-9 and -3.

Apoptosis Analysis[1]

Cell Line: RKO and HT-29 cells
Concentration: 0 μM; 75 μM; 150 μM
Incubation Time: 24 hours
Result: Induced apoptosis of colorectal cells (RKO and HT-29).
Molecular Weight

230.30

Formula

C₁₅H₁₈O₂

CAS No.

24268-41-5

SMILES

O=C1/C=C(C)/CC/C=C(C)/CC2=C1C(C)=CO2

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