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Results for "

anaphylaxis

" in MedChemExpress (MCE) Product Catalog:

53

Inhibitors & Agonists

3

Biochemical Assay Reagents

5

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7

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4

Isotope-Labeled Compounds

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-Y1703
    HATU

    		Biochemical Assay Reagents Others
    HATU is a third-generation uronium salt peptide coupling reagent. HATU increases the rate of peptide coupling reactions, activates amino acids, promotes peptide bond formation in both solution-phase and solid-phase synthesis, and also facilitates peptide assembly, fragment coupling, and linear peptide cyclization. HATU can promote the N-acylation of chitosan to generate amide-linked cationic derivatives with a controllable degree of substitution. HATU is commonly used in amine acylation reactions .
    HATU
  • HY-145191
    MrgprX2 antagonist-1
    5 Publications Verification

    		 Mas-related G-protein-coupled Receptor (MRGPR) Inflammation/Immunology
    MrgprX2 antagonist-1 is an MrgprX2 antagonist extracted from patent WO2021092264A1, example E23. MrgprX2 antagonist-1 can be used for the research of inflammatory disorders of the skin .
    MrgprX2 antagonist-1
  • HY-145192
    MrgprX2 antagonist-2

    		Mas-related G-protein-coupled Receptor (MRGPR) Inflammation/Immunology
    MrgprX2 antagonist-2 is an MrgprX2 antagonist extracted from patent WO2021092262A1, example E163. MrgprX2 antagonist-2 can be used for the research of inflammatory disorders of the skin .
    MrgprX2 antagonist-2
  • HY-145193
    MrgprX2 antagonist-3

    		Mas-related G-protein-coupled Receptor (MRGPR) Inflammation/Immunology
    MrgprX2 antagonist-3 is an MrgprX2 antagonist extracted from patent WO2021092240A1, example E117. MrgprX2 antagonist-3 can be used for the research of inflammatory disorders of the skin .
    MrgprX2 antagonist-3
  • HY-P0009A
    Cetrorelix Acetate
    1 Publications Verification

    SB-75 acetate

    		 GnRH Receptor Neurological Disease Endocrinology
    Cetrorelix Acetate (SB-75 acetate) is a potent gonadotropin-releasing hormone (GnRH) receptor antagonist with an IC50 of 1.21 nM .
    Cetrorelix Acetate
  • HY-P0171
    Motixafortide
    3 Publications Verification

    BKT140 (4-fluorobenzoyl); BL-8040; TF14016

    		 CXCR Endocrinology Cancer
    Motixafortide (BKT140 4-fluorobenzoyl) is a novel CXCR4 antagonist with an IC50 vakue of ～1 nM.
    Motixafortide
  • HY-Y0912
    HBTU

    N-HBTU

    		 Biochemical Assay Reagents Inflammation/Immunology
    HBTU (N-HBTU) is a guanidinium-based peptide coupling reagent and immunological sensitizer. HBTU can be used in combination with bases such as DIPEA (HY-130142) to complete coupling reactions, with HOBt and TMU as by-products. HBTU is a standard reagent in automated solid-phase peptide synthesis, particularly for the Fmoc/tBu strategy, which effectively promotes coupling steps, but it is not suitable for sterically hindered amino acids or dipeptide derivatives. HBTU can induce rhinitis, dermatitis, bronchial asthma and severe allergic reactions. HBTU can be used to study the pathogenesis of allergic reactions, occupational rhinitis, allergic contact dermatitis and bronchial asthma .
    HBTU
  • HY-145195
    MrgprX2 antagonist-5

    		Mas-related G-protein-coupled Receptor (MRGPR) Inflammation/Immunology
    MrgprX2 antagonist-5 is an MrgprX2 antagonist extracted from patent WO2020223255A1, example 16. MrgprX2 antagonist-5 can be used for the research of inflammatory disorders of the skin .
    MrgprX2 antagonist-5
  • HY-145194
    MrgprX2 antagonist-4

    		Mas-related G-protein-coupled Receptor (MRGPR) Inflammation/Immunology
    MrgprX2 antagonist-4 is an MrgprX2 antagonist extracted from patent US20210128561A1, compound B-51 E117. MrgprX2 antagonist-4 can be used for the research of inflammatory disorders of the skin .
    MrgprX2 antagonist-4
  • HY-B1148
    Furaltadone hydrochloride
    1 Publications Verification

    Altafur hydrochloride

    		 Bacterial Infection Inflammation/Immunology
    Furaltadone hydrochloride is an orally active antibacterial agent that can be used for the study of intestinal Salmonella infections. Furaltadone has in vitro inhibitory effects on Staphylococcus. In addition, Furaltadone shows inhibitory effects on allergic reactions .
    Furaltadone hydrochloride
  • HY-113331
    Thromboxane B2
    1 Publications Verification

    		 Prostaglandin Receptor Cardiovascular Disease Inflammation/Immunology
    Thromboxane B2 is a prostaglandin derivative that is released during anaphylaxis. Thromboxane B2 induces arterial contraction and platelet aggregation. Thromboxane B2 is a biological inactive product and circulating catabolite of thromboxane A2. Thromboxane B2 levels in peripheral venous blood and coronary sinus blood can be used as a diagnostic marker for angina. Thromboxane B2 level in serum is also associated with inhibition of COX-1 activity inhibition in platelets. Thromboxane B2 is a major product of prostaglandin endoperoxide metabolism. Thromboxane B2 produces dose-related decreases in airflow rate, tidal volume and dynamic lung compliance, whilst simultaneously increasing pulmonary airway resistance in dog model. Thromboxane B2 appears to be a naturally occurring bronchoactive metabolite in the bioconversion of arachidonic acid .
    Thromboxane B2
  • HY-113465
    Leukotriene E4
    1 Publications Verification

    LTE4

    		 Endogenous Metabolite Inflammation/Immunology
    Leukotriene E4 (LTE4) is produced by the action of dipeptidase on LTD4. Leukotriene E4 is one of the constituents of slow-reacting substance of anaphylaxis (SRS-A). Leukotriene E4 accumulates in both plasma and urine and urinary excretion of Leukotriene E4 is most often used as an indicator of asthma.
    Leukotriene E4
  • HY-B0010B
    Formoterol-1
    1 Publications Verification

    (±)Formoterol

    		 Adrenergic Receptor Inflammation/Immunology
    Formoterol ((±)Formoterol) is an orally active β2-selective agonist. Formoterol potently relaxes the peripheral airways through stimulating the beta 2-adrenoceptors selectively as is the case in the central airways and that it significantly inhibits IgE-mediated slow reactive substance of anaphylaxis (SRS-A) release through beta-adrenoceptor stimulation .
    Formoterol-1
  • HY-W181102
    NFAT Inhibitor-2

    		Calcineurin Cardiovascular Disease Neurological Disease Inflammation/Immunology
    NFAT Inhibitor-2 is a potent inhibitor of calcineurin NFAT signalling. Calcineurin is a serine/threonine protein phosphatase regulated by Ca2+ and calmodulin. NFAT Inhibitor-2 has the potential for the research of inflammatory disease, an autoimmune disorder, a cardiovascular disease, a neurodegenerative disease, a disease occurring with uncontrolled cell proliferation and/or differentiation, an angiogenesis-related disease, an allergy, anaphylaxis and alopecia (extracted from patent WO2016207212A1, compound 17) .
    NFAT Inhibitor-2
  • HY-139690
    CCG258747
    1 Publications Verification

    		 Opioid Receptor G Protein-coupled Receptor Kinase (GRK) Mas-related G-protein-coupled Receptor (MRGPR) Cardiovascular Disease Inflammation/Immunology
    CCG258747 is a selective GRK2 inhibitor (IC50 = 18 nM) with high selectivity over GRK1, GRK5, PKA, and ROCK1 (518, 83, > 5500, and > 550-fold, respectively). CCG258747 also blocks the internalization of the µ-opioid receptor (MOR). CCG258747 attenuates IgE mediated anaphylaxis by inhibiting GRK2 and FcεRI signaling pathway but activates mast cells via MRGPRX2 and MRGPRB2. CCG258747 can be used to study diseases related to overexpression of GRK2 (such as heart failure, opioid tolerance) .
    CCG258747
  • HY-P4452
    PRL 2915
    1 Publications Verification

    		 Somatostatin Receptor Urotensin Receptor Endocrinology
    PRL 2915 is a potent human somatostatin subtype 2 receptor (hsst2) antagonist with a Ki of 12 nM .
    PRL 2915
  • HY-107607
    FPL-55712 free base

    		Leukotriene Receptor Inflammation/Immunology
    FPL-55712 free base is a leukotriene receptor antagonist. FPL-55712 free base is also an antagonist of slow reacting substance of anaphylaxis (SRS-A). FPL-55712 free base inhibits leukotriene-induced bronchoconstriction .
    FPL-55712 free base
  • HY-N11072
    Tremulacin

    		Lipoxygenase Leukotriene Receptor Reactive Oxygen Species (ROS) MMP Inflammation/Immunology
    Tremulacin is a 5-LOX inhibitor. Tremulacin reduces the biosynthesis of LTB4 and slow-reacting substances of anaphylaxis. Tremulacin alleviates carrageenan-induced paw edema in rats, croton oil-induced ear edema in mice, and acetic acid-induced writhing response in mice. Tremulacin inhibits TNF-α-stimulated ROS production and MMP-1 expression, and promotes collagen secretion in human dermal fibroblasts. Tremulacin is investigated for studies on inflammation-related diseases .
    Tremulacin
  • HY-106358
    Andolast free base

    CR 2039 free base; Dizolast free base

    		 Phosphodiesterase (PDE) Inflammation/Immunology
    Andolast (CR 2039) (free base) is an anti-allergic agent. Andolast can inhibit cAMP-phosphodiesterase with an IC50 value of 50 μM. Andolast can be used for the research of asthma .
    Andolast free base
  • HY-113465S
    Leukotriene E4-d5

    LTE4-d5

    		 Endogenous Metabolite Inflammation/Immunology
    Leukotriene E4-d5 is the deuterium labeled Leukotriene E4. Leukotriene E4 (LTE4) is produced by the action of dipeptidase on LTD4. Leukotriene E4 is one of the constituents of slow-reacting substance of anaphylaxis (SRS-A). Leukotriene E4 accumulates in both plasma and urine and urinary excretion of Leukotriene E4 is most often used as an indicator of asthma.
    Leukotriene E4-d5
  • HY-107928A
    Iron–Dextran(Fe 25-35% w/w)

    		Biochemical Assay Reagents Others
    Iron-Dextran is an injectable complex of iron and dextran, a complex carbohydrate. It is often used to improve iron deficiency anemia, a condition characterized by low levels of iron in the blood due to insufficient dietary intake or malabsorption. Iron-glucan works by providing a source of supplemental iron that the body can use to produce hemoglobin, the protein responsible for carrying oxygen in the blood. However, caution should be exercised when taking iron dextran because it may cause hypersensitivity reactions, including anaphylaxis, and may also increase the risk of infection or other adverse reactions. Therefore, it should only be administered under the supervision of a qualified healthcare provider in a clinical setting.
    Iron–Dextran(Fe 25-35% w/w)
  • HY-N2024B
    Maltose solution, 20% in H2O

    		Endogenous Metabolite Glycosidase Metabolic Disease
    Maltose solution, 20% in H2O is a 20% aqueous maltose solution. Maltose is a disaccharide composed of two glucose molecules linked together. Maltose is an endogenous metabolic product in plants, yeast, or bacteria, and it participates in carbon source storage and metabolism. Maltose is a key core metabolite and main transport form in the temporary starch degradation, carbon output, and subsequent sucrose synthesis metabolism of the night chloroplast. In X. dendrorhous, maltose can act as a sugar donor and is converted into isomaltulose by α-glucosidase. Maltose can act as a osmotic agent, supporting continuous capillary ultrafiltration and preventing severe metabolic disorders .
    Maltose solution, 20% in H2O
  • HY-13218
    Acitazanolast

    WP-871

    		 Histamine Receptor Inflammation/Immunology
    Acitazanolast is an orally active antiallergic agent, can inhibit histamine release. Acitazanolast can be used in study of type I anaphylaxis (immediate) caused by IgE antibodies .
    Acitazanolast
  • HY-121007
    Bepafant

    Web2170

    		 Platelet-activating Factor Receptor (PAFR) Others
    Bepafant (Web2170) is a platelet-activating factor (PAF) antagonist that protects against anaphylactic lethality in active and passive anaphylaxis models in mice and guinea pigs in a dose-dependent manner and attenuates bronchoconstriction and blood pressure changes in anaphylaxis.
    Bepafant
  • HY-113331S1
    Thromboxane B2-d9

    		Isotope-Labeled Compounds Prostaglandin Receptor Inflammation/Immunology
    Thromboxane B2-d9 is deuterium labeled Thromboxane B2. Thromboxane B2 is a prostaglandin derivative that is released during anaphylaxis. Thromboxane B2 induces arterial contraction and platelet aggregation .
    Thromboxane B2-d9
  • HY-113331S
    Thromboxane B2-d4

    		Isotope-Labeled Compounds Inflammation/Immunology
    Thromboxane B2-D4 is the deuterium labeled Thromboxane B2. Thromboxane B2 is a prostaglandin derivative that is released during anaphylaxis. Thromboxane B2 induces arterial contraction and platelet aggregation .
    Thromboxane B2-d4
  • HY-106358A
    Andolast

    CR 2039; Dizolast

    		 Phosphodiesterase (PDE) Inflammation/Immunology
    Andolast (CR 2039) is an anti-allergic agent. Andolast can inhibit cAMP-phosphodiesterase with an IC50 value of 50 μM. Andolast can be used for the research of asthma .
    Andolast
  • HY-113456S
    Leukotriene D4-d5

    		Drug Metabolite Endogenous Metabolite Cardiovascular Disease Inflammation/Immunology
    Leukotriene D4-d5 is the deuterium labeled Leukotriene D4. Leukotriene D4 is one of the constituents of slow-reacting substance of anaphylaxis (SRS-A) produced by the metabolism of LTC4 by γ-glutamyl transpeptidase. Leukotriene D4 is the first cysteinyl-leukotriene metabolite of LTC4. Leukotriene D4-induced bronchoconstriction and enhanced vascular permeability contribute to the pathogenesis of asthma and acute hypersensitivity.
    Leukotriene D4-d5
  • HY-P0009B
    Cetrorelix diacetate

    SB-75 diacetate

    		 GnRH Receptor Neurological Disease Endocrinology
    Cetrorelix diacetate (SB-075 diacetate) is a potent gonadotropin-releasing hormone (GnRH) receptor antagonist with an IC50 of 1.21 nM .
    Cetrorelix diacetate
  • HY-N8276
    Ro 3-1314

    9a,12a-Octadecadiynoic acid

    		 Lipoxygenase Metabolic Disease Inflammation/Immunology
    Ro 3-1314 (9a,12a-Octadecadiynoic acid) is a plant lipoxygenase inhibitor. Ro 3-1314 is a linoleic acid metabolism inhibitor. Ro 3-1314 stimulates the antigen-induced contraction of guinea-pig tracheal spirals and the immunological release of slow reacting substance of anaphylaxis (SRS-A) from actively sensitized guinea-pig lung fragments .
    Ro 3-1314
  • HY-19125
    BN-50726

    		Platelet-activating Factor Receptor (PAFR) Cardiovascular Disease Inflammation/Immunology
    BN-50726 is a potent platelet-activating factor (PAF) receptor antagonist. BN-50726 inhibits PAF-induced effects (e.g., [3H]-serotonin release and hypotension) (IC50=5.40 nM). BN-50726 is promising for research of PAF-mediated pathological processes (e.g., inflammation, anaphylaxis, hypotension) .
    BN-50726
  • HY-131374
    TN14003

    		CXCR Cancer
    TN14003 is a CXCR4 inhibitor. TN14003 has antitumor activity .
    TN14003
  • HY-106645
    Cloxacepride

    		Calmodulin Neurological Disease Inflammation/Immunology
    Cloxacepride is an orally active and potent antiallergic agent. Cloxacepride is a CaM (calmodulin) antagonist. Cloxacepride has anti-PCA (passive cutaneous anaphylaxis) activity .
    Cloxacepride
  • HY-158272
    Penicillin/OVA

    		Bacterial Inflammation/Immunology
    Penicillin/OVA is a conjugate of penicillin and Ovalbumins, that is utilized as an antigen in immunological research. Penicillin/OVA causes IgE-dependent anaphylactic response to penicillin in mice .
    Penicillin/OVA
  • HY-N5067
    Rhodiocyanoside A

    Multifidin

    		 Others Inflammation/Immunology
    Rhodiocyanoside A is found to show antiallergic activity in a passive cutaneous anaphylaxis test in rat .
    Rhodiocyanoside A
  • HY-N10279
    Gymconopin C

    		Others Infection
    Gymconopin C shows an antiallergic effect on ear passive cutaneous anaphylaxis reactions in mice.
    Gymconopin C
  • HY-159926
    Tixanox sodium

    RS-7540

    		 Histamine Receptor Inflammation/Immunology
    Tixanox sodium (RS-7540), an anti-allergic compound, is a potent inhibitor of mediator release in the IgE-mediated passive cutaneous anaphylaxis (PCA) reaction .
    Tixanox sodium
  • HY-106806
    NZ-107

    		Leukotriene Receptor Inflammation/Immunology
    NZ-107 is an orally active leukotriene receptor antagonist. NZ-107 can inhibit anaphylaxis reaction. NZ-107 can be used for the researches of inflammation and immunology .
    NZ-107
  • HY-W754020
    Elbanizine

    		Histamine Receptor Others
    Elbanizine inhibits histamine, bradykinin, histamin-release from rat mast cells (IC50 of 0.26 μM) and the IgE-mediated passive cutaneous anaphylaxis (PCA) reaction. Elbanizine exhibits antiallergic and antiasthmatic in guinea pig model .
    Elbanizine
  • HY-145193A
    (R)-MrgprX2 antagonist-3

    		Mas-related G-protein-coupled Receptor (MRGPR) Inflammation/Immunology
    (R)-MrgprX2 antagonist-3 (compound E118) is an MrgprX2 antagonist extracted from patent WO2021092240A1, example E118. (R)-MrgprX2 antagonist-3 can be used for the research of inflammatory disorders of the skin .
    (R)-MrgprX2 antagonist-3
  • HY-N4027
    Hydrangenol 8-O-glucoside

    Hydrangenol 8-O-β-D-glucopyranoside

    		 Cholinesterase (ChE) Neurological Disease
    Hydrangenol 8-O-glucoside (Hydrangenol 8-O-β-D-glucopyranoside) can be isolated from Hydrangea macrophyllu. Hydrangenol 8-O-glucoside is an AChE inhibitor (IC50: 22.66 μM). Hydrangenol 8-O-glucoside inhibits passive cutaneous anaphylaxis (PCA) reaction .
    Hydrangenol 8-O-glucoside
  • HY-106358R
    Andolast free base (Standard)

    CR 2039 free base (Standard); Dizolast free base (Standard)

    		 Reference Standards Phosphodiesterase (PDE) Inflammation/Immunology
    Andolast (free base) (Standard) is the analytical standard of Andolast (free base). This product is intended for research and analytical applications. Andolast (CR 2039) (free base) is an anti-allergic agent. Andolast can inhibit cAMP-phosphodiesterase with an IC50 value of 50 μM. Andolast can be used for the research of asthma .
    Andolast free base (Standard)
  • HY-139247
    pNPS-DHA

    		Drug Derivative Inflammation/Immunology
    pNPS-DHA (Compound 19) is an orally active DHA-ethanolamide (DHEA) derivative that has antiallergic activity. pNPS-DHA inhibits IgE-dependent passive cutaneous anaphylaxis (PCA) reaction in mice. pNPS-DHA has anti-degranulating activity in RBL-2H3 mast cells with an IC50 of 15 μM .
    pNPS-DHA
  • HY-126127
    BRL 22321 free base

    		Histamine Receptor Inflammation/Immunology
    BRL 22321 free base is a stabilizer with similar mast cell stabilizing activity to Cromolyn sodium (HY-B0320A) and also has some smooth muscle relaxant activity. BRL 22321 free base is more potent than Cromolyn sodium (HY-B0320A) in inhibiting rat passive cutaneous and peritoneal anaphylaxis and antigen-induced histamine release from passively sensitized rat peritoneal cells .
    BRL 22321 free base
  • HY-152862
    Dibutepinephrine

    		Drug Intermediate Adrenergic Receptor Inflammation/Immunology
    Dibutepinephrine is an orally active adrenergic prodrug. Dibutepinephrine rapidly alleviates allergic symptoms. Dibutepinephrine can be used for the research of severe allergic reactions .
    Dibutepinephrine
  • HY-137312
    Carbuterol

    SKF 40383-A

    		 Adrenergic Receptor Inflammation/Immunology
    Carbuterol (SKF 40383-A) is a selective β2-adrenergic receptor agonist that primarily targets bronchial smooth muscle, exhibiting significant bronchodilatory and anti-allergic activity. Carbuterol can directly inhibit the immunologically induced release of histamine and slow-reacting substance of anaphylaxis (SRS-A), thereby alleviating allergic responses. Carbuterol exerts mild β1-mediated cardiac stimulation and is applicable to studies related to respiratory and immune-related diseases such as asthma and allergic disorders .
    Carbuterol
  • HY-137312A
    Carbuterol hydrochloride

    SKF 40383-A hydrochloride

    		 Adrenergic Receptor Inflammation/Immunology
    Carbuterol (SKF 40383-A) hydrochloride is a selective β2-adrenergic receptor agonist that primarily targets bronchial smooth muscle, exhibiting significant bronchodilatory and anti-allergic activity. Carbuterol hydrochloride can directly inhibit the immunologically induced release of histamine and slow-reacting substance of anaphylaxis (SRS-A), thereby alleviating allergic responses. In addition, it exerts mild β1-mediated cardiac stimulation and is applicable to studies related to respiratory and immune-related diseases such as asthma and allergic disorders .
    Carbuterol hydrochloride
  • HY-N18182
    Mudanpioside E

    		Glycosidase Inflammation/Immunology
    Mudanpioside E is an orally effective paeoniflorin-type monoterpene glycoside antiallergic agent, with an IC50 of 40.34 μM against IgE-mediated β-hexosaminidase release. Mudanpioside E reverses the inhibitory effect of the modified Xiaoqinglong Decoction extract (paeonia root component removed) on passive cutaneous anaphylaxis in mice. Mudanpioside E itself shows no activity against passive cutaneous anaphylaxis. Mudanpioside E can be used in research related to allergic diseases .
    Mudanpioside E
  • HY-165395
    AY 25674

    		Phosphodiesterase (PDE) Inflammation/Immunology
    AY 25674 is an orally active antiallergic agent and a PDE inhibitor. AY 25674 inhibits the release of allergic histamine from mast cells. AY 25674 suppresses passive anaphylaxis induced by reaginic (IgE) antibodies. AY 25674 does not inhibit the increased vascular permeability caused by non-reaginic antibodies, serotonin or histamine. AY 25674 reaches its peak activity shortly after administration; rapid tolerance occurs at high doses. AY 25674 can be used in research related to passive anaphylaxis .
    AY 25674
  • HY-N19243
    6-O-Senesioyl plenolin

    		Histamine Receptor Inflammation/Immunology
    6-O-Senesioyl plenolin is a sesquiterpene lactone found in Centipeda minima with antiallergic activity. 6-O-Senesioyl plenolin inhibits histamine release from mast cells (IC50 = 18 μM) and suppresses pigment exudation in passive cutaneous anaphylaxis tests. 6-O-Senesioyl plenolin can be used in research related to allergy .
    6-O-Senesioyl plenolin

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