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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
7 Results for "
chronic unpredictable mild stress
" in MedChemExpress (MCE) Product Catalog:
Products (7)
7 Results for "chronic unpredictable mild stress" in MCE Product Catalog:
Cat. No.: HY-18698
CAS No.: 142326-59-8
Target:
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L-701324 is a potent, orally active NMDA receptor antagonist that antagonizes the activity of the NMDA receptor by blocking its glycine B binding site. L-701324 binds with high affinity to rat brain membranes (IC50=2 nM). L-701324 has antidepressant activity .
Cat. No.: HY-N0660
CAS No.: 55466-05-2
Cat. No.: HY-P11222
CAS No.: 2614435-43-5
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Research Areas:
Cat. No.: HY-174395
Research Areas:
CD-10 is an orally active and BBB-penatrable Keap1-Nrf2 protein-protein interaction (PPI) inhibitor. CD-10 binds to Keap1 with a KD value of 193 nM. CD-10 exhibits potent anti-oxidative and anti-inflammatory effects through Keap1-Nrf2 pathway activation, evidenced by reduced levels of MDA, IL-4, IL-10 and increased expression of HO-1. CD-10 effectively alleviated anxiety and depressive behaviors and restored serum neurotransmitter levels by promoting Nrf2 nuclear translocation in the chronic unpredictable mild stress (CUMS) mouse model. CD-10 can be used for the study of depression.
Cat. No.: HY-184410
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nNOS-PDZ-IN-1 is an orally active, blood-brain barrier-penetrant inhibitor of neuronal nitric oxide synthase-PDZ domain (nNOS-PDZ), with an IC50 of 0.76 μM and a KD of 0.55 μM. nNOS-PDZ-IN-1 binds to the nNOS-PDZ domain, occupies its binding site and disrupts its interaction with the serotonin transporter. nNOS-PDZ-IN-1 exhibits antidepressant activity without addiction potential or movement-related side effects. nNOS-PDZ-IN-1 can be used in research related to major depressive disorder .
Cat. No.: HY-N0660R
CAS No.: 55466-05-2
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
