5875-50-3
Chemical Structure
D-4'-Phosphopantothenate
Synonym(s): Phosphopantothenic acid; 4'-Phosphopantothenate
- CAS No.: 5875-50-3
- Formula:C9H18NO8P
- Molecular Weight:299.21
InChIKey: XHFVGHPGDLDEQO-ZETCQYMHSA-N
SMILES: O=P(O)(O)OCC(C)(C)[C@@H](O)C(NCCC(O)=O)=O
Biological Activity: D-4'-Phosphopantothenate (Phosphopantothenic acid; 4'-Phosphopantothenate) serves as a precursor for coenzyme A synthesis and is a key metabolite in the biosynthetic pathway of pantothenic acid and coenzyme A. The expression level of D-4'-Phosphopantothenate is downregulated in macrophages exposed to graphene nanosheets or the CD36 ligand sulfo-N-succinimidyl oleate. D-4'-Phosphopantothenate is positively correlated with the sucrose preference index in mice subjected to chronic unpredictable mild stress (CUMS), and its expression can be upregulated by the aqueous extract of Cistanche tubulosa. D-4'-Phosphopantothenate can be used in studies related to depression comorbid with sexual dysfunction[1][2][3].
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D-4'-Phosphopantothenate | D-4'-Phosphopantothenate (Phosphopantothenic acid; 4'-Phosphopantothenate) serves as a precursor for coenzyme A synthesis and is a key metabolite in the biosynthetic pathway of pantothenic acid and coenzyme A. The expression level of D-4'-Phosphopantothenate is downregulated in macrophages exposed to graphene nanosheets or the CD36 ligand sulfo-N-succinimidyl oleate. D-4'-Phosphopantothenate is positively correlated with the sucrose preference index in mice subjected to chronic unpredictable mild stress (CUMS), and its expression can be upregulated by the aqueous extract of Cistanche tubulosa. D-4'-Phosphopantothenate can be used in studies related to depression comorbid with sexual dysfunction. | |||||||||||||||||||||
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- [1]. Thomès L, et al. Mosaic Evolution of the Phosphopantothenate Biosynthesis Pathway in Bacteria and Archaea. Genome biology and evolution. 2021 Feb 03;13(2):evaa262.
- [2]. Adamson SX, et al. Metabolomic insights of macrophage responses to graphene nanoplatelets: Role of scavenger receptor CD36. PloS one. 2018;13(11):e0207042.
- [3]. Sun A, et al. A metabolomics approach reveals the pharmacological effects and mechanisms of Cistanche tubulosa stems and its combination with fluoxetine on depression in comorbid with sexual dysfunction. Journal of ethnopharmacology. 2025 Jan 30;337(Pt 2):118891.
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