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Cat. No.: HY-165471

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D-4'-Phosphopantothenate

Name: D-4'-Phosphopantothenate
Brand: MedChemExpress
SKU: HY-165471
Price: 204.00 USD
Availability: InStock
Rating: 5 (1 reviews)

(Synonyms: Phosphopantothenic acid; 4'-Phosphopantothenate)

D-4'-Phosphopantothenate (Phosphopantothenic acid; 4'-Phosphopantothenate) serves as a precursor for coenzyme A synthesis and is a key metabolite in the biosynthetic pathway of pantothenic acid and coenzyme A. The expression level of D-4'-Phosphopantothenate is downregulated in macrophages exposed to graphene nanosheets or the CD36 ligand sulfo-N-succinimidyl oleate. D-4'-Phosphopantothenate is positively correlated with the sucrose preference index in mice subjected to chronic unpredictable mild stress (CUMS), and its expression can be upregulated by the aqueous extract of Cistanche tubulosa. D-4'-Phosphopantothenate can be used in studies related to depression comorbid with sexual dysfunction.

For research use only. We do not sell to patients.

CAS No.: 5875-50-3
Formula: C₉H₁₈NO₈P
Molecular Weight:299.21

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

D-4'-Phosphopantothenate Chemical Structure

CAS No.: 5875-50-3

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- Description
- In Vitro
- In Vivo
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Biological Activity

Description

All Endogenous Metabolite Isoforms :

In Vitro

D‑4'-Phosphopantothenate is synthesized via the archaeal pathway (dependent on PoK and PPS) in symbiotic Candidatus Entoporibacteria, whereas free-living Candidatus Pelagiporibacteria produce this metabolite through the canonical bacterial pathway (dependent on PS and type III PanK); both groups of microorganisms utilize bacterial-type DPCK to complete the subsequent biosynthesis of coenzyme A^[1].
D-4'-Phosphopantothenate is downregulated in RAW 264.7 mouse macrophages exposed to graphene nanosheets or the CD36 ligand sulfo-N-succinimidyl oleate^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

D-4'-Phosphopantothenate correlates positively with improved antidepressant-related sucrose preference in CUMS-induced mice with comorbid depression and sexual dysfunction, with its testicular levels upregulated by Cistanche tubulosa aqueous extract exposure^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 5875-50-3
Molecular Weight 299.21
Formula C₉H₁₈NO₈P
SMILES

O=P(O)(O)OCC(C)(C)[C@@H](O)C(NCCC(O)=O)=O
Synonyms

Phosphopantothenic acid; 4'-Phosphopantothenate
Structure Classification
- Ketones, Aldehydes, Acids
Initial Source
- Endogenous metabolite
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Thomès L, et al. Mosaic Evolution of the Phosphopantothenate Biosynthesis Pathway in Bacteria and Archaea. Genome biology and evolution. 2021 Feb 03;13(2):evaa262.

[2]. Adamson SX, et al. Metabolomic insights of macrophage responses to graphene nanoplatelets: Role of scavenger receptor CD36. PloS one. 2018;13(11):e0207042. [Content Brief]

[3]. Sun A, et al. A metabolomics approach reveals the pharmacological effects and mechanisms of Cistanche tubulosa stems and its combination with fluoxetine on depression in comorbid with sexual dysfunction. Journal of ethnopharmacology. 2025 Jan 30;337(Pt 2):118891.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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