D-4'-Phosphopantothenate
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D-4'-Phosphopantothenate (Phosphopantothenic acid; 4'-Phosphopantothenate) serves as a precursor for coenzyme A synthesis and is a key metabolite in the biosynthetic pathway of pantothenic acid and coenzyme A. The expression level of D-4'-Phosphopantothenate is downregulated in macrophages exposed to graphene nanosheets or the CD36 ligand sulfo-N-succinimidyl oleate. D-4'-Phosphopantothenate is positively correlated with the sucrose preference index in mice subjected to chronic unpredictable mild stress (CUMS), and its expression can be upregulated by the aqueous extract of Cistanche tubulosa. D-4'-Phosphopantothenate can be used in studies related to depression comorbid with sexual dysfunction.
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- Purity : 98.56%
- CAS No.: 5875-50-3
- 화학식: C9H18NO8P
- 분자량:299.21
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보관:
-20°C, stored under nitrogen, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)
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Biological Activity
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Chemical Information
- Protocol
- 순도&문서
- References
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Help & FAQs
All Endogenous Metabolite Isoforms
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Biological Activity
제품 설명
In Vitro
D‑4'-Phosphopantothenate is synthesized via the archaeal pathway (dependent on PoK and PPS) in symbiotic Candidatus Entoporibacteria, whereas free-living Candidatus Pelagiporibacteria produce this metabolite through the canonical bacterial pathway (dependent on PS and type III PanK); both groups of microorganisms utilize bacterial-type DPCK to complete the subsequent biosynthesis of coenzyme A[1].
D-4'-Phosphopantothenate is downregulated in RAW 264.7 mouse macrophages exposed to graphene nanosheets or the CD36 ligand sulfo-N-succinimidyl oleate[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 5875-50-3
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Appearance Solid
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분자량 299.21
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화학식 C9H18NO8P
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Color White to off-white
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SMILES
O=P(O)(O)OCC(C)(C)[C@@H](O)C(NCCC(O)=O)=O
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Synonyms
Phosphopantothenic acid; 4'-Phosphopantothenate
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Structure Classification
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Initial Source
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선적
Room temperature in continental US; may vary elsewhere.
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보관
-20°C, stored under nitrogen, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)
Protocol
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RNA extraction experimental
By lysing cells, releasing RNA, and removing impurities such as proteins and DNA, high-purity RNA products are finally obtained. The commonly used traditional method is the guanidine isothiocyanate/phenol/chloroform method (Trizol), which is suitable for a variety of animal materials including animal tissues, microorganisms, cultured cells, etc., and most plant materials.
순도&문서
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Data Sheet (276 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
D-4'-Phosphopantothenate Related Classifications
HY-165471 Related Classifications
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Keywords
- D-4'-Phosphopantothenate
- 5875-50-3
- Phosphopantothenic acid
- 4'-Phosphopantothenate
- Endogenous Metabolite
- Drug Intermediate
- macrophages
- sulfo-N-succinimidyl oleate
- Candidatus Entoporibacteria
- CD36
- CUMS mice
- RAW 264.7 mouse macrophages
- coenzyme A
- pantothenate and coenzyme A biosynthesis pathway
- Cistanche tubulosa
- graphene nanoplatelets
- Inhibitor
- inhibitor
- inhibit