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corylifolia

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Akt (2) Apoptosis (5) Autophagy (3) Bacterial (3) Calcium Channel (1) Calmodulin (1) COX (1) Cytochrome P450 (1) DNA/RNA Synthesis (2) Dopamine Transporter (1) Drug Intermediate (1) Estrogen Receptor/ERR (2) Fc Receptor (FcR) (1) Histamine Receptor (1) Keap1-Nrf2 (1) Monoamine Transporter (1) NF-κB (1) NO Synthase (1) p38 MAPK (1) RANKL/RANK (1) Reactive Oxygen Species (ROS) (3) Reference Standards (4) Topoisomerase (1) UGT (1)
By Research Areas:	Cancer (10) Infection (5) Inflammation/Immunology (2) Metabolic Disease (3) Neurological Disease (2)

By Targets:

Akt (2)

Apoptosis (5)

Autophagy (3)

Bacterial (3)

Calcium Channel (1)

Calmodulin (1)

COX (1)

Cytochrome P450 (1)

DNA/RNA Synthesis (2)

Dopamine Transporter (1)

Drug Intermediate (1)

Estrogen Receptor/ERR (2)

Fc Receptor (FcR) (1)

Histamine Receptor (1)

Keap1-Nrf2 (1)

Monoamine Transporter (1)

NF-κB (1)

NO Synthase (1)

p38 MAPK (1)

RANKL/RANK (1)

Reactive Oxygen Species (ROS) (3)

Reference Standards (4)

Topoisomerase (1)

UGT (1)

By Research Areas:

Cancer (10)

Infection (5)

Inflammation/Immunology (2)

Metabolic Disease (3)

Neurological Disease (2)

Inhibitors & Agonists

Natural
Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-13065

Isobavachalcone 5+ Cited Publications Corylifolinin; Isobacachalcone	Akt Reactive Oxygen Species (ROS) Apoptosis Autophagy	Cancer
Isobavachalcone (Corylifolinin) is derived from Psoralea corylifolia* Linn.* and is a potent inhibitor of Akt signaling pathway, which induces apoptosis in human cancer cells (Inhibits OVCAR-8 cell growth with an IC₅₀ value of 7.92 μM). Isobavachalcone also induces Reactive Oxyen Species (ROS) generation in OVCAR-8 cells and has exhibit cancer anti-promotive and anti-proliferative activity .

HY-N0233

Bavachin 10+ Cited Publications Corylifolin	Estrogen Receptor/ERR	Cancer
Bavachin, a flavonoid first isolated from seeds of P. corylifolia, acts as a phytoestrogen that activates the estrogen receptors ERα and ERβ with EC₅₀s of 320 and 680 nM, respectively.

HY-N0720

Neobavaisoflavone Maximum Cited Publications 15 Publications Verification	Apoptosis DNA/RNA Synthesis	Inflammation/Immunology Cancer
Neobavaisoflavone, a flavonoid, is isolated from the seeds of Psoralea corylifolia. Neobavaisoflavone exhibits anti-inflammatory, anti-cancer and anti-oxidation activities. Neobavaisoflavone inhibits DNA polymerase at moderate to high concentrations. Neobavaisoflavone also inhibits platelet aggregation .

HY-N0762

Isobavachin 5 Publications Verification	Cytochrome P450 UGT p38 MAPK NF-κB NO Synthase COX Fc Receptor (FcR) RANKL/RANK Keap1-Nrf2 Reactive Oxygen Species (ROS) Apoptosis Autophagy	Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Isobavachin is an orally active, blood-brain barrier-penetrating prenylated flavonoid present in Psoralea corylifolia. Isobavachin inhibits human CYP2B6, CYP2C9, CYP2C19, UGT1A1, UGT1A9, and UGT2B7. Isobavachin suppresses MAPK activation, NF-κB nuclear translocation, overexpression of iNOS/COX-2, FcεRI-mediated signaling pathways, and RANKL-induced osteoclastogenesis. Isobavachin induces autophagy, cytotoxicity, neuronal differentiation, and NRF2 activation; it alleviates oxidative damage, inflammatory responses, apoptosis, iron accumulation, mitochondrial biogenesis, and mast cell degranulation. Isobavachin is applicable to research related to liver injury, inflammatory diseases, osteoporosis, liver cancer, prostate cancer, glioma, periodontitis-induced bone loss, and Alzheimer's disease .

HY-N7506

13-Hydroxyisobakuchiol Delta3,2-Hydroxylbakuchiol	Monoamine Transporter Dopamine Transporter	Neurological Disease
13-Hydroxyisobakuchiol (Delta3,2-Hydroxylbakuchiol), an analog of Bakuchiol (HY-N0235) that can be isolated from Psoralea corylifolia (L.), is a potent selective monoamine transporter inhibitor. 13-Hydroxyisobakuchiol is more selective for the dopamine transporter (DAT) (IC₅₀ = 0.58 μM) and norepinephrine transporter (NET) (IC₅₀ = 0.69 μM) than for the serotonin transporter (SERT) (IC₅₀ = 312.02 μM). 13-Hydroxyisobakuchiol increases the activity of intact mice and improves the decreased activity of reserpinized mice in vivo. 13-Hydroxyisobakuchiol can be used for the research of disorders such as Parkinson's disease and depression .

HY-N7503

Psoralenoside	Drug Intermediate Bacterial	Infection Cancer
Psoralenoside is an orally active benzofuran glycoside. Psoralenoside is isolated from the fruits of Psoralea corylifolia. As a metabolite precursor, Psoralenoside undergoes deglycosylation by intestinal flora to form Psoralen (HY-N0053). Psoralenoside is applicable to research related to cancer and bacterial infections .

HY-N7504

Isopsoralenoside	Bacterial	Infection Metabolic Disease Cancer
Isopsoralenoside is a benzofuran glycoside from Psoralea corylifolia. Isopsoralenoside can be quickly metabolized to Psoralen (HY-N0053) in digestive tract contents. Isopsoralenoside show estrogen-like activity, osteoblastic proliferation accelerating activity, antitumor effects and antibacterial activity .

HY-N9184

Furano(2'',3'',7,6)-4'-hydroxyflavanone	Others	Others
Furano(2'',3'',7,6)-4'-hydroxyflavanone is a Flavonoids product that can be isolated from the seeds of Psoralea corylifolia. .

HY-N10820

Psoracorylifol C	Bacterial	Infection
Psoracorylifol C is a natural product. Psoracorylifol C has important activity against Helicobacter pylori. Psoracorylifol C can be isolated from the seeds of Psoralea corylifolia .

HY-N0720R

Neobavaisoflavone (Standard)	Reference Standards Apoptosis DNA/RNA Synthesis	Cancer
Neobavaisoflavone (Standard) is the analytical standard of Neobavaisoflavone. This product is intended for research and analytical applications. Neobavaisoflavone, a flavonoid, is isolated from the seeds of Psoralea corylifolia. Neobavaisoflavone exhibits anti-inflammatory, anti-cancer and anti-oxidation activities. Neobavaisoflavone inhibits DNA polymerase at moderate to high concentrations. Neobavaisoflavone also inhibits platelet aggregation .

HY-N7503R

Psoralenoside (Standard)	Reference Standards Histamine Receptor Calcium Channel Calmodulin	Infection Metabolic Disease Cancer
Psoralenoside is a benzofuran glycoside from Psoralea corylifolia . Psoralenoside exhibits high binding affinities against histaminergic H1, calmodulin, and voltage-gated L-type calcium channels (E-value≥-6.5 Kcal/mol) . Psoralenoside shows estrogen-like activity, osteoblastic proliferation accelerating activity, antitumor effects and antibacterial activity .

HY-121236

Bavachromene	Others	Others
Bavachromene is a chromenochalcone from the seeds of Psoralea corylifolia with estrogenic activities .

HY-N0233R

Bavachin (Standard) Corylifolin (Standard)	Reference Standards Estrogen Receptor/ERR	Cancer
Bavachin (Standard) is the analytical standard of Bavachin. This product is intended for research and analytical applications. Bavachin, a flavonoid first isolated from seeds of P. corylifolia, acts as a phytoestrogen that activates the estrogen receptors ERα and ERβ with EC50s of 320 and 680 nM, respectively.

HY-N11698

Bakuchicin Allopsoralen	Topoisomerase	Infection
Bakuchicin (Allopsoralen) is a compound that can be found in Psoralea corylifolia. It has certain inhibitory activity against topoisomerase II. In the cell model infected with Simian virus 40 (SV40), the IC₅₀ of Bakuchicin against topoisomerase II is 404 μM. Bakuchicin can be used in the research of the anti-infection field .

HY-13065R

Isobavachalcone (Standard) Corylifolinin (Standard); Isobacachalcone (Standard)	Reference Standards Akt Reactive Oxygen Species (ROS) Apoptosis Autophagy	Cancer
Isobavachalcone (Standard) is the analytical standard of Isobavachalcone. This product is intended for research and analytical applications. Isobavachalcone (Corylifolinin) is derived from Psoralea corylifolia Linn. and is a potent inhibitor of Akt signaling pathway, which induces apoptosis in human cancer cells (Inhibits OVCAR-8 cell growth with an IC50 value of 7.92 μM). Isobavachalcone also induces Reactive Oxyen Species (ROS) generation in OVCAR-8 cells and has exhibit cancer anti-promotive and anti-proliferative activity .

HY-N9242

Isoficusin A	Others	Others
Isoficusin A is a Flavonoids product that can be isolated from the seeds of Psoralea corylifolia Linn. .

HY-N9288

8-(6-Hydroperoxy-3,7-dimethyl-2,7-octadienyloxy)psoralen	Others	Others
8-(6-Hydroperoxy-3,7-dimethyl-2,7-octadienyloxy)psoralen is a Coumarins product that can be isolated from the herbs of Psoralea corylifolia L. .

Isobavachalcone 5+ Cited Publications Corylifolinin; Isobacachalcone	Chalcones Flavonoids Classification of Application Fields Leguminosae Phenols Polyphenols Psoralea corylifolia L. Plants Glycyrrhiza uralensis Fisch. Disease Research Fields Source Classification Cancer	Akt Reactive Oxygen Species (ROS) Apoptosis Autophagy
Isobavachalcone (Corylifolinin) is derived from Psoralea corylifolia* Linn.* and is a potent inhibitor of Akt signaling pathway, which induces apoptosis in human cancer cells (Inhibits OVCAR-8 cell growth with an IC₅₀ value of 7.92 μM). Isobavachalcone also induces Reactive Oxyen Species (ROS) generation in OVCAR-8 cells and has exhibit cancer anti-promotive and anti-proliferative activity .

Bavachin 10+ Cited Publications Corylifolin	Flavonoids Classification of Application Fields Leguminosae Flavonones Phenols Polyphenols Psoralea corylifolia L. Plants Disease Research Fields Source Classification Cancer	Estrogen Receptor/ERR
Bavachin, a flavonoid first isolated from seeds of P. corylifolia, acts as a phytoestrogen that activates the estrogen receptors ERα and ERβ with EC₅₀s of 320 and 680 nM, respectively.

Neobavaisoflavone Maximum Cited Publications 15 Publications Verification	Structural Classification Flavonoids Classification of Application Fields Leguminosae Phenols Polyphenols Psoralea corylifolia L. Plants Disease Research Fields Isoflavones Source Classification Cancer	Apoptosis DNA/RNA Synthesis
Neobavaisoflavone, a flavonoid, is isolated from the seeds of Psoralea corylifolia. Neobavaisoflavone exhibits anti-inflammatory, anti-cancer and anti-oxidation activities. Neobavaisoflavone inhibits DNA polymerase at moderate to high concentrations. Neobavaisoflavone also inhibits platelet aggregation .

Isobavachin 5 Publications Verification	Structural Classification Flavonoids Neurological Disease Classification of Application Fields Leguminosae Flavonones Phenols Polyphenols Psoralea corylifolia L. Plants Disease Research Fields Source Classification	Cytochrome P450 UGT p38 MAPK NF-κB NO Synthase COX Fc Receptor (FcR) RANKL/RANK Keap1-Nrf2 Reactive Oxygen Species (ROS) Apoptosis Autophagy
Isobavachin is an orally active, blood-brain barrier-penetrating prenylated flavonoid present in Psoralea corylifolia. Isobavachin inhibits human CYP2B6, CYP2C9, CYP2C19, UGT1A1, UGT1A9, and UGT2B7. Isobavachin suppresses MAPK activation, NF-κB nuclear translocation, overexpression of iNOS/COX-2, FcεRI-mediated signaling pathways, and RANKL-induced osteoclastogenesis. Isobavachin induces autophagy, cytotoxicity, neuronal differentiation, and NRF2 activation; it alleviates oxidative damage, inflammatory responses, apoptosis, iron accumulation, mitochondrial biogenesis, and mast cell degranulation. Isobavachin is applicable to research related to liver injury, inflammatory diseases, osteoporosis, liver cancer, prostate cancer, glioma, periodontitis-induced bone loss, and Alzheimer's disease .

13-Hydroxyisobakuchiol Delta3,2-Hydroxylbakuchiol	Structural Classification Monophenols Leguminosae Phenols Psoralea corylifolia L. Plants Source Classification	Monoamine Transporter Dopamine Transporter
13-Hydroxyisobakuchiol (Delta3,2-Hydroxylbakuchiol), an analog of Bakuchiol (HY-N0235) that can be isolated from Psoralea corylifolia (L.), is a potent selective monoamine transporter inhibitor. 13-Hydroxyisobakuchiol is more selective for the dopamine transporter (DAT) (IC₅₀ = 0.58 μM) and norepinephrine transporter (NET) (IC₅₀ = 0.69 μM) than for the serotonin transporter (SERT) (IC₅₀ = 312.02 μM). 13-Hydroxyisobakuchiol increases the activity of intact mice and improves the decreased activity of reserpinized mice in vivo. 13-Hydroxyisobakuchiol can be used for the research of disorders such as Parkinson's disease and depression .

Psoralenoside	Infection Structural Classification Classification of Application Fields Simple Phenylpropanols Leguminosae Metabolic Disease Phenylpropanoids Psoralea corylifolia L. Plants Disease Research Fields Source Classification	Drug Intermediate Bacterial
Psoralenoside is an orally active benzofuran glycoside. Psoralenoside is isolated from the fruits of Psoralea corylifolia. As a metabolite precursor, Psoralenoside undergoes deglycosylation by intestinal flora to form Psoralen (HY-N0053). Psoralenoside is applicable to research related to cancer and bacterial infections .

Isopsoralenoside	Infection Classification of Application Fields Leguminosae Ketones, Aldehydes, Acids Metabolic Disease Psoralea corylifolia L. Plants Disease Research Fields Source Classification	Bacterial
Isopsoralenoside is a benzofuran glycoside from Psoralea corylifolia. Isopsoralenoside can be quickly metabolized to Psoralen (HY-N0053) in digestive tract contents. Isopsoralenoside show estrogen-like activity, osteoblastic proliferation accelerating activity, antitumor effects and antibacterial activity .

Furano(2'',3'',7,6)-4'-hydroxyflavanone	Flavonoids Leguminosae Flavonones Psoralea corylifolia L. Plants Source Classification	Others
Furano(2'',3'',7,6)-4'-hydroxyflavanone is a Flavonoids product that can be isolated from the seeds of Psoralea corylifolia. .

Psoracorylifol C	Microorganisms Leguminosae Coumarins Phenylpropanoids Psoralea corylifolia L. Plants Source Classification	Bacterial
Psoracorylifol C is a natural product. Psoracorylifol C has important activity against Helicobacter pylori. Psoracorylifol C can be isolated from the seeds of Psoralea corylifolia .

Neobavaisoflavone (Standard)	Structural Classification Flavonoids Leguminosae Phenols Polyphenols Psoralea corylifolia L. Plants Isoflavones Source Classification	Reference Standards Apoptosis DNA/RNA Synthesis
Neobavaisoflavone (Standard) is the analytical standard of Neobavaisoflavone. This product is intended for research and analytical applications. Neobavaisoflavone, a flavonoid, is isolated from the seeds of Psoralea corylifolia. Neobavaisoflavone exhibits anti-inflammatory, anti-cancer and anti-oxidation activities. Neobavaisoflavone inhibits DNA polymerase at moderate to high concentrations. Neobavaisoflavone also inhibits platelet aggregation .

Psoralenoside (Standard)	Structural Classification Simple Phenylpropanols Leguminosae Phenylpropanoids Psoralea corylifolia L. Plants Source Classification	Reference Standards Histamine Receptor Calcium Channel Calmodulin
Psoralenoside is a benzofuran glycoside from Psoralea corylifolia . Psoralenoside exhibits high binding affinities against histaminergic H1, calmodulin, and voltage-gated L-type calcium channels (E-value≥-6.5 Kcal/mol) . Psoralenoside shows estrogen-like activity, osteoblastic proliferation accelerating activity, antitumor effects and antibacterial activity .

Bavachromene	Flavonoids Chalcones Classification of Application Fields Leguminosae Other Diseases Phenols Polyphenols Psoralea corylifolia L. Plants Disease Research Fields Source Classification	Others
Bavachromene is a chromenochalcone from the seeds of Psoralea corylifolia with estrogenic activities .

Bavachin (Standard) Corylifolin (Standard)	Structural Classification Flavonoids Leguminosae Flavonones Phenols Polyphenols Psoralea corylifolia L. Plants Source Classification	Reference Standards Estrogen Receptor/ERR
Bavachin (Standard) is the analytical standard of Bavachin. This product is intended for research and analytical applications. Bavachin, a flavonoid first isolated from seeds of P. corylifolia, acts as a phytoestrogen that activates the estrogen receptors ERα and ERβ with EC50s of 320 and 680 nM, respectively.

Bakuchicin Allopsoralen	Leguminosae Coumarins Phenylpropanoids Psoralea corylifolia L. Plants Source Classification	Topoisomerase
Bakuchicin (Allopsoralen) is a compound that can be found in Psoralea corylifolia. It has certain inhibitory activity against topoisomerase II. In the cell model infected with Simian virus 40 (SV40), the IC₅₀ of Bakuchicin against topoisomerase II is 404 μM. Bakuchicin can be used in the research of the anti-infection field .

Isobavachalcone (Standard) Corylifolinin (Standard); Isobacachalcone (Standard)	Structural Classification Chalcones Flavonoids Leguminosae Phenols Polyphenols Psoralea corylifolia L. Plants Glycyrrhiza uralensis Fisch. Source Classification	Reference Standards Akt Reactive Oxygen Species (ROS) Apoptosis Autophagy
Isobavachalcone (Standard) is the analytical standard of Isobavachalcone. This product is intended for research and analytical applications. Isobavachalcone (Corylifolinin) is derived from Psoralea corylifolia Linn. and is a potent inhibitor of Akt signaling pathway, which induces apoptosis in human cancer cells (Inhibits OVCAR-8 cell growth with an IC50 value of 7.92 μM). Isobavachalcone also induces Reactive Oxyen Species (ROS) generation in OVCAR-8 cells and has exhibit cancer anti-promotive and anti-proliferative activity .

Isoficusin A	Flavonoids Leguminosae Psoralea corylifolia L. Plants Fabaceae Source Classification	Others
Isoficusin A is a Flavonoids product that can be isolated from the seeds of Psoralea corylifolia Linn. .

8-(6-Hydroperoxy-3,7-dimethyl-2,7-octadienyloxy)psoralen	Leguminosae Coumarins Phenylpropanoids Psoralea corylifolia L. Plants Source Classification	Others
8-(6-Hydroperoxy-3,7-dimethyl-2,7-octadienyloxy)psoralen is a Coumarins product that can be isolated from the herbs of Psoralea corylifolia L. .

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Inhibitors & Agonists

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Products