1. PI3K/Akt/mTOR NF-κB Metabolic Enzyme/Protease Immunology/Inflammation Apoptosis Autophagy
  2. Akt Reactive Oxygen Species Apoptosis Autophagy
  3. Isobavachalcone

Isobavachalcone  (Synonyms: Corylifolinin; Isobacachalcone)

Cat. No.: HY-13065 Purity: 99.01%
COA Handling Instructions

Isobavachalcone (Corylifolinin) is derived from Psoralea corylifolia Linn. and is a potent inhibitor of Akt signaling pathway, which induces apoptosis in human cancer cells (Inhibits OVCAR-8 cell growth with an IC50 value of 7.92 μM). Isobavachalcone also induces Reactive Oxyen Species (ROS) generation in OVCAR-8 cells and has exhibit cancer anti-promotive and anti-proliferative activity.

For research use only. We do not sell to patients.

Isobavachalcone Chemical Structure

Isobavachalcone Chemical Structure

CAS No. : 20784-50-3

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
USD 77 In-stock
Solution
10 mM * 1 mL in DMSO USD 77 In-stock
Solid
1 mg USD 40 In-stock
5 mg USD 70 In-stock
10 mg USD 115 In-stock
25 mg USD 240 In-stock
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Customer Review

Based on 8 publication(s) in Google Scholar

Top Publications Citing Use of Products

    Isobavachalcone purchased from MedChemExpress. Usage Cited in: Int Immunopharmacol. 2013 Jan;15(1):38-41.  [Abstract]

    IBC inhibits iNOS protein induced by TLRs agonists. A–C) RAW264.7 cells are pretreated with 20 or 50 μM IBC for 1 h and then further stimulated with MALP-2 (10 μg/mL) (A), LPS (10 μg/mL) (B), or poly[I:C] (10 μg/mL) (C) for an additional 8 h. Cell lysates are analyzed for iNOS and β-actin protein by immunoblots. Veh, vehicle; IBC, isobavachalcone.

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    Description

    Isobavachalcone (Corylifolinin) is derived from Psoralea corylifolia Linn. and is a potent inhibitor of Akt signaling pathway, which induces apoptosis in human cancer cells (Inhibits OVCAR-8 cell growth with an IC50 value of 7.92 μM). Isobavachalcone also induces Reactive Oxyen Species (ROS) generation in OVCAR-8 cells and has exhibit cancer anti-promotive and anti-proliferative activity[1].

    IC50 & Target

    IC50: 7.92 μM (OVCAR-8 cell)[1]

    In Vitro

    Isobavachalcone (6.0-48.0 μM; 72 hours; OVCAR-8, PC3, A549, MCF-7, L-02 and HUVEC cells) treatment inhibits the proliferation of human cancer cells. Isobavachalcone inhibits PC3, A549, MCF-7, L-02 and HUVEC cells growth with IC50 values of 15.06 μM, 32.2 μM, 28.29 μM, 31.61 μM and 31.3 μM, respectively[1].
    Isobavachalcone (0-18 μM; 6 hours; OVCAR-8 and PC3 cells) treatment results in a concentration-and time-dependent down-regulation of the Ser-473 phosphorylation of Akt and GSK3b phosphorylation[1].
    Isobavachalcone (0-18 μM; 72 hours; OVCAR-8 and PC3 cells) treatment causes apoptosis via caspase- and ROS-involved mitochondrial pathway[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Cell Proliferation Assay[1]

    Cell Line: OVCAR-8, PC3, A549, MCF-7, L-02 and HUVEC cells
    Concentration: 6.0-48.0 μM
    Incubation Time: 72 hours
    Result: Inhibited the proliferation of human cancer cells.

    Western Blot Analysis[1]

    Cell Line: OVCAR-8 or PC3 cells
    Concentration: 0 μM, 6 μM, 12 μM, and 18 μM
    Incubation Time: 6 hours
    Result: A concentration-and time-dependent down-regulation of the Ser-473 phosphorylation of Akt. GSK3b phosphorylation was also inhibited in a concentration- and time-dependent manner.

    Apoptosis Analysis[1]

    Cell Line: OVCAR-8 cells and PC3 cells
    Concentration: 0 μM, 6 μM, 12 μM, and 18 μM
    Incubation Time: 72 hours
    Result: Led to dose dependent increase of apoptosis.
    In Vivo

    Isobavachalcone (20 mg/kg; intraperitoneal injection; for 0.5-24 hours; female Kunming mice) treatment results in an increase in blood glucose levels, reaching a maximum within 1 hour and maintaining until 4 hours post-dosing[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Seven-week-old specific pathogen-free female Kunming mice (18-22 g)[1]
    Dosage: 20 mg/kg
    Administration: Intraperitoneal injection; for 0.5, 1, 2, 4, 6, 8, 12, 24 hours
    Result: Increased in blood glucose levels.
    Molecular Weight

    324.37

    Formula

    C20H20O4

    CAS No.
    Appearance

    Solid

    Color

    Light yellow to yellow

    SMILES

    O=C(/C=C/C1=CC=C(C=C1)O)C2=CC=C(C(C/C=C(C)\C)=C2O)O

    Structure Classification
    Initial Source
    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage

    4°C, protect from light

    *In solvent : -80°C, 1 year; -20°C, 6 months (protect from light)

    Solvent & Solubility
    In Vitro: 

    DMSO : 11 mg/mL (33.91 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 3.0829 mL 15.4145 mL 30.8290 mL
    5 mM 0.6166 mL 3.0829 mL 6.1658 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months (protect from light). When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

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    Working solution concentration: mg/mL
    Purity & Documentation

    Purity: 99.01%

    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months (protect from light). When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 3.0829 mL 15.4145 mL 30.8290 mL 77.0725 mL
    5 mM 0.6166 mL 3.0829 mL 6.1658 mL 15.4145 mL
    10 mM 0.3083 mL 1.5414 mL 3.0829 mL 7.7072 mL
    15 mM 0.2055 mL 1.0276 mL 2.0553 mL 5.1382 mL
    20 mM 0.1541 mL 0.7707 mL 1.5414 mL 3.8536 mL
    25 mM 0.1233 mL 0.6166 mL 1.2332 mL 3.0829 mL
    30 mM 0.1028 mL 0.5138 mL 1.0276 mL 2.5691 mL
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    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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    Product Name:
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