1. PI3K/Akt/mTOR
    Metabolic Enzyme/Protease
    Immunology/Inflammation
    NF-κB
    Apoptosis
    Autophagy
  2. Akt
    Reactive Oxygen Species
    Apoptosis
    Autophagy
  3. Isobavachalcone

Isobavachalcone (Synonyms: Corylifolinin; Isobacachalcone)

Cat. No.: HY-13065 Purity: 99.01%
Handling Instructions

Isobavachalcone (Corylifolinin) is derived from Psoralea corylifolia Linn. and is a potent inhibitor of Akt signaling pathway, which induces apoptosis in human cancer cells (Inhibits OVCAR-8 cell growth with an IC50 value of 7.92 μM). Isobavachalcone also induces Reactive Oxyen Species (ROS) generation in OVCAR-8 cells and has exhibit cancer anti-promotive and anti-proliferative activity.

For research use only. We do not sell to patients.

Isobavachalcone Chemical Structure

Isobavachalcone Chemical Structure

CAS No. : 20784-50-3

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10 mM * 1 mL in DMSO USD 92 In-stock
Estimated Time of Arrival: December 31
5 mg USD 84 In-stock
Estimated Time of Arrival: December 31
10 mg USD 144 In-stock
Estimated Time of Arrival: December 31
25 mg USD 288 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 3 publication(s) in Google Scholar

Top Publications Citing Use of Products

    Isobavachalcone purchased from MCE. Usage Cited in: Int Immunopharmacol. 2013 Jan;15(1):38-41.

    IBC inhibits iNOS protein induced by TLRs agonists. A–C) RAW264.7 cells are pretreated with 20 or 50 μM IBC for 1 h and then further stimulated with MALP-2 (10 μg/mL) (A), LPS (10 μg/mL) (B), or poly[I:C] (10 μg/mL) (C) for an additional 8 h. Cell lysates are analyzed for iNOS and β-actin protein by immunoblots. Veh, vehicle; IBC, isobavachalcone.

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    Description

    Isobavachalcone (Corylifolinin) is derived from Psoralea corylifolia Linn. and is a potent inhibitor of Akt signaling pathway, which induces apoptosis in human cancer cells (Inhibits OVCAR-8 cell growth with an IC50 value of 7.92 μM). Isobavachalcone also induces Reactive Oxyen Species (ROS) generation in OVCAR-8 cells and has exhibit cancer anti-promotive and anti-proliferative activity[1].

    IC50 & Target

    IC50: 7.92 μM (OVCAR-8 cell)[1]

    In Vitro

    Isobavachalcone (6.0-48.0 μM; 72 hours; OVCAR-8, PC3, A549, MCF-7, L-02 and HUVEC cells) treatment inhibits the proliferation of human cancer cells. Isobavachalcone inhibits PC3, A549, MCF-7, L-02 and HUVEC cells growth with IC50 values of 15.06 μM, 32.2 μM, 28.29 μM, 31.61 μM and 31.3 μM, respectively[1].
    Isobavachalcone (0-18 μM; 6 hours; OVCAR-8 and PC3 cells) treatment results in a concentration-and time-dependent down-regulation of the Ser-473 phosphorylation of Akt and GSK3b phosphorylation[1].
    Isobavachalcone (0-18 μM; 72 hours; OVCAR-8 and PC3 cells) treatment causes apoptosis via caspase- and ROS-involved mitochondrial pathway[1].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Cell Proliferation Assay[1]

    Cell Line: OVCAR-8, PC3, A549, MCF-7, L-02 and HUVEC cells
    Concentration: 6.0-48.0 μM
    Incubation Time: 72 hours
    Result: Inhibited the proliferation of human cancer cells.

    Western Blot Analysis[1]

    Cell Line: OVCAR-8 or PC3 cells
    Concentration: 0 μM, 6 μM, 12 μM, and 18 μM
    Incubation Time: 6 hours
    Result: A concentration-and time-dependent down-regulation of the Ser-473 phosphorylation of Akt. GSK3b phosphorylation was also inhibited in a concentration- and time-dependent manner.

    Apoptosis Analysis[1]

    Cell Line: OVCAR-8 cells and PC3 cells
    Concentration: 0 μM, 6 μM, 12 μM, and 18 μM
    Incubation Time: 72 hours
    Result: Led to dose dependent increase of apoptosis.
    In Vivo

    Isobavachalcone (20 mg/kg; intraperitoneal injection; for 0.5-24 hours; female Kunming mice) treatment results in an increase in blood glucose levels, reaching a maximum within 1 hour and maintaining until 4 hours post-dosing[1].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Seven-week-old specific pathogen-free female Kunming mice (18-22 g)[1]
    Dosage: 20 mg/kg
    Administration: Intraperitoneal injection; for 0.5, 1, 2, 4, 6, 8, 12, 24 hours
    Result: Increased in blood glucose levels.
    Molecular Weight

    324.37

    Formula

    C₂₀H₂₀O₄

    CAS No.

    20784-50-3

    SMILES

    O=C(/C=C/C1=CC=C(C=C1)O)C2=CC=C(C(C/C=C(C)\C)=C2O)O

    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage

    4°C, protect from light

    *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

    Solvent & Solubility
    In Vitro: 

    DMSO : 11 mg/mL (33.91 mM; Need ultrasonic and warming)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 3.0829 mL 15.4145 mL 30.8290 mL
    5 mM 0.6166 mL 3.0829 mL 6.1658 mL
    10 mM 0.3083 mL 1.5414 mL 3.0829 mL
    *Please refer to the solubility information to select the appropriate solvent.
    References

    Purity: 99.01%

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    Keywords:

    IsobavachalconeCorylifolinin IsobacachalconeAktReactive Oxygen SpeciesApoptosisAutophagyPKBProtein kinase BInhibitorinhibitorinhibit

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