Antiplatelet flavonoids from seeds of Psoralea corylifolia

  • J Nat Prod. 1996 Jul;59(7):671-2. doi: 10.1021/np960157y.
W J Tsai  1 ,  W C Hsin ,  C C Chen
Affiliations
  • 1. National Research Institute of Chinese Medicine, Taipei, Taiwan, Republic of China.
PMID: 8759164 DOI: 10.1021/np960157y
Abstract

The MeOH extract of the seeds of Psoralea corylifolia L. was found to inhibit the aggregation of rabbit platelets induced by arachidonic acid, Collagen, and platelet activating factor. Bioassay-directed fractionation led to the isolation of three Flavonoids, isobavachalcone (1), neobavaiso-flavone (2), and bavachin (3). Compounds 1 and 2 inhibited platelet aggregation.

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