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cytochalasan

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Antibiotic (1) Apoptosis (1) Arp2/3 Complex (1) Endogenous Metabolite (2)
By Research Areas:	Cancer (5)

Inhibitors & Agonists

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

Cytoglobosin C	Endogenous Metabolite	Cancer
Cytoglobosin C, a cytochalasan derivative, shows potent cytotoxicity against both SGC-7901 and A549 cell lines (IC₅₀<10 μM) .

19-O-Acetylchaetoglobosin A	Arp2/3 Complex	Cancer
19-O-Acetylchaetoglobosin A, a cytochalasan alkaloid, is a fungal metabolite originally isolated from C. globosum that has actin polymerization inhibitory and cytotoxic activities. 19-O-Acetylchaetoglobosin A is cytotoxic to HeLa cervical cancer cells .

Chaetoglobosin F	Endogenous Metabolite	Cancer
Chaetoglobosin F is a cytochalasan-based alkaloid from Chaetomium globosum. Chaetoglobosin F exhibits cytotoxicity against human nasopharyngeal epidermoid tumor cell KB, with IC₅₀ of 52.0 µM .

Cytochalasin Z2	Others	Others
Cytochalasin Z2 is a 24-oxa-[14]cytochalasan. Cytochalasin Z2 is isolated from wheat cultures of Pyrenophora semeniperda. Cytochalasin Z2 shows no activity in root elongation assays of wheat and tomato seedlings .

Boerelasin E	Apoptosis	Cancer
Boerelasin E is the first cytochalasan possessing a cis-configured Δ21(22) double bond that can be isolated from endophytic fungus Boeremia exigua. Boerelasin E exhibits antiproliferative activity against MCF-7 cells (IC₅₀=20.52 μM) more potent than cisplatin (HY-17394). Boerelasin E inhibits the complete cell division of MCF-7 cells by arresting them in the G2/M phase and inducing apoptosis^[1].

TMC-169	Antibiotic	Cancer
TMC-169 is a potent antibiotic of the Aspochalasin group that can be isolated from Aspergillus flavipes. TMC-169 exhibits anti-tumor activity against multiple cancer cells. TMC-169 can be used for the research of cancer, such as hematologic malignancies, non-small cell lung cancer, breast cancer, and glioma .

Cytoglobosin C	Alkaloids Microorganisms Classification of Application Fields Disease Research Fields Indole Alkaloids Cancer Source Classification	Endogenous Metabolite
Cytoglobosin C, a cytochalasan derivative, shows potent cytotoxicity against both SGC-7901 and A549 cell lines (IC₅₀<10 μM) .

19-O-Acetylchaetoglobosin A	Alkaloids Microorganisms Classification of Application Fields Disease Research Fields Cancer Source Classification	Arp2/3 Complex
19-O-Acetylchaetoglobosin A, a cytochalasan alkaloid, is a fungal metabolite originally isolated from C. globosum that has actin polymerization inhibitory and cytotoxic activities. 19-O-Acetylchaetoglobosin A is cytotoxic to HeLa cervical cancer cells .

Chaetoglobosin F	Structural Classification Alkaloids Microorganisms Pyrrole Alkaloids Indole Alkaloids Source Classification	Endogenous Metabolite
Chaetoglobosin F is a cytochalasan-based alkaloid from Chaetomium globosum. Chaetoglobosin F exhibits cytotoxicity against human nasopharyngeal epidermoid tumor cell KB, with IC₅₀ of 52.0 µM .

Cytochalasin Z2	Structural Classification Alkaloids Microorganisms Indole Alkaloids Source Classification	Others
Cytochalasin Z2 is a 24-oxa-[14]cytochalasan. Cytochalasin Z2 is isolated from wheat cultures of Pyrenophora semeniperda. Cytochalasin Z2 shows no activity in root elongation assays of wheat and tomato seedlings .

Boerelasin E	Microorganisms Ketones, Aldehydes, Acids Phenols Source Classification	Apoptosis
Boerelasin E is the first cytochalasan possessing a cis-configured Δ21(22) double bond that can be isolated from endophytic fungus Boeremia exigua. Boerelasin E exhibits antiproliferative activity against MCF-7 cells (IC₅₀=20.52 μM) more potent than cisplatin (HY-17394). Boerelasin E inhibits the complete cell division of MCF-7 cells by arresting them in the G2/M phase and inducing apoptosis^[1].

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