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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
46 Results for "
deruxtecan
" in MedChemExpress (MCE) Product Catalog:
Products (46)
46 Results for "deruxtecan" in MCE Product Catalog:
32
32 Publications Verification
Synonyms: MC-GGFG-DXD
Target:
Áreas de investigación:
Deruxtecan is an ADC drug-linker conjugate composed of an DX-8951 derivative (DXd) and a maleimide-GGFG peptide linker, used for synthesizing Trastuzumab deruxtecan (HY-138298A) and Patritumab deruxtecan (HY-P99813) .
9
9 Cited Publications
Synonyms: T-DXd; DS-8201; DS-8201a
9
9 Cited Publications
Synonyms: T-DXd (solution); DS-8201 (solution); DS-8201a (solution)
5
2
2 Cited Publications
Synonyms: DS-1062 (solution); Dato-DXd (solution)
2
2 Cited Publications
Referencia número: HY-P99843
No. CAS: 2267989-53-5
Target:
Áreas de investigación:
2
2 Cited Publications
Referencia número: HY-141598B
No. CAS: 2238831-60-0
Synonyms: DS-1062; Dato-DXd
Áreas de investigación:
Datopotamab deruxtecan (DS-1062) is a TROP2-targeted antibody-drug conjugate (ADC) with human TROP2 Kd of 0.74 nmol/L. Datopotamab deruxtecan consists of the antibody Datopotamab (HY-P99843) and the toxic molecule-linker conjugate Deruxtecan (HY-13631E). Datopotamab deruxtecan binds TROP2, triggers internalization and lysosomal trafficking and releases DXd topoisomerase I inhibitor payload. Datopotamab deruxtecan disrupts DNA function, induces DNA damage, apoptosis, and bystander killing of tumor microenvironment cells. Datopotamab deruxtecan can be used in research related to triple-negative breast cancer, gastric cancer, and non-small cell lung cancer .
1
Target:
Áreas de investigación:
Patritumab deruxtecan (HER3-DXd) is an antibody-drug conjugate (ADC) consisting of a fully human anti-HER3 IgG1 monoclonal antibody Patritumab (HY-P99275) attached to a topoisomerase I inhibitor payload via a tetrapeptide-based cleavable linker. Patritumab deruxtecan shows anticancer activity .
1
1 Cited Publications
Referencia número: HY-164152A
1
1 Cited Publications
Referencia número: HY-164152
Áreas de investigación:
Referencia número: HY-P3371
No. CAS: 2484870-92-8
Synonyms: DS-7300a; MABX-9001a; I-DXd
Áreas de investigación:
Áreas de investigación:
Gly-Mal-GGFG-Deruxtecan 2-hydroxypropanamide is the drug-linker conjugate for ADC, containing ADC linker Gly-Mal-GGFG and ADC cytotoxin Deruxtecan 2-hydroxypropanamide .
Target:
Áreas de investigación:
Deruxtecan 2-hydroxypropanamide is a highly stable Deruxtecan (HY-13631E) analog that specifically binds to receptors highly expressed in tumor cells .
Referencia número: HY-164734
No. CAS: 2610074-57-0
Synonyms: R-DXd; DS-6000
Target:
Áreas de investigación:
Raludotatug Deruxtecan is an antibody-drug conjugate targeting CDH6, with an EC50 of 64.7 ng/mL in humans, 70.4 ng/mL in cynomolgus monkeys, and 228 ng/mL in mice. Raludotatug Deruxtecan specifically binds to CDH6 on the surface of cancer cells, triggers lysosomal internalization, and releases the DXd payload that inhibits TOP1. Raludotatug Deruxtecan induces DNA damage, Chk1 phosphorylation, caspase-3 cleavage, apoptosis, and bystander cell death. Raludotatug Deruxtecan is applicable to research related to serous ovarian cancer and renal cell carcinoma .
Referencia número: HY-P990028
No. CAS: 2610074-56-9
Áreas de investigación:
Referencia número: HY-45672
No. CAS: 1599440-20-6
Target:
Áreas de investigación:
Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH is an ADC Linker that can be used to synthesize Drug-Linker Conjugates for ADC. Especially for the synthesis of Deruxtecan (HY-13631E), a toxic drug-linker conjugate .
Referencia número: HY-177442
Synonyms: DS-3939
Referencia número: HY-13631EG
No. CAS: 1599440-13-7
Synonyms: MC-GGFG-DXD (GMP)
Referencia número: HY-13631ES4
Synonyms: MC-GGFG-DXD-d5
Referencia número: HY-164835
No. CAS: 2760408-75-9
Synonyms: VcMMAE-(PAB-GGFG-AMAA)Exatecan; SMP-54418
Áreas de investigación:
VcMMAE-Deruxtecan (VcMMAE-(PAB-GGFG-AMAA)Exatecan; SMP-54418) is a drug-linker conjugate for ADC, composed of linker-payload molecule conjugate VcMMAE (HY-15575) and linker-payload molecule conjugate Deruxtecan (PAB-GGFG-AMAA)Exatecan) (HY-13631E). VcMMAE-Deruxtecan can be used in the synthesis of ADCs.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
