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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
8 Results for "
gene replacement
" in MedChemExpress (MCE) Product Catalog:
Products (8)
8 Results for "gene replacement" in MCE Product Catalog:
21
21 Publications Verification
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SCR7 pyrazine is a DNA ligase IV inhibitor that blocks nonhomologous end-joining (NHEJ) in a ligase IV-dependent manner. SCR7 pyrazine increases the efficiency of Cas9-mediated homology-directed repair (HDR). SCR7 pyrazine induces cell apoptosis and has anticancer activity .
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5-Methylcytidine 5′-triphosphate (5-Methyl-CTP) trisodium is a modified ribonucleoside 5′-triphosphate. When incorporated into mRNA, 5-Methylcytidine 5′-triphosphate trisodium enhances the translation efficiency and stability of the mRNA, and reduces the innate immune response. 5-Methylcytidine 5′-triphosphate trisodium can be used in studies related to gene replacement and vaccination applications .
OF-02 is an ionizable lipid for mRNA delivery and a key component of lipid nanoparticles (LNPs). OF-02 is protonated in the acidic endosomal environment to promote endosomal escape of mRNA and efficiently induce protein expression in target cells. OF-02 relies on the pH-responsive membrane fusion properties to form a complex with mRNA and destroy the endosomal membrane structure to achieve mRNA release in the cytoplasm. OF-02 is mainly used in the development of mRNA vaccines, gene editing, and protein replacement therapy[1][2][3].
Cat. No.: HY-147338
CAS No.: 327174-86-7
Synonyms: 5-Methyl-CTP
Target:
Research Areas:
5-Methylcytidine 5′-triphosphate (5-Methyl-CTP) is a modified ribonucleoside 5′-triphosphate. When incorporated into mRNA, 5-Methylcytidine 5′-triphosphate enhances the translation efficiency and stability of the mRNA, and reduces the innate immune response. 5-Methylcytidine 5′-triphosphate can be used in studies related to gene replacement and vaccination applications .
Cat. No.: HY-147338S
Synonyms: 5-Methyl-CTP-d3 trisodium
Research Areas:
5-Methylcytidine 5′-triphosphate-d3 (5-Methyl-CTP-d3) trisodium is the deuterium labeled 5-Methylcytidine 5’-triphosphate (5-Methyl-CTP) trisodium (HY-147338A). 5-Methylcytidine 5’-triphosphate trisodium is a modified ribonucleoside 5′-triphosphate. When incorporated into mRNA, 5-Methylcytidine 5′-triphosphate trisodium enhances the translation efficiency and stability of the mRNA, and reduces the innate immune response. 5-Methylcytidine 5′-triphosphate trisodium can be used in studies related to gene replacement and vaccination applications .
Cat. No.: HY-147338S2
Synonyms: 5-Methyl-CTP-d8 trisodium
Research Areas:
5-Methylcytidine 5′-triphosphate-d8 (5-Methyl-CTP-d8) trisodium is the deuterium-labeled 5-Methylcytidine 5’-triphosphate (5-Methyl-CTP) trisodium (HY-147338A). 5-Methylcytidine 5’-triphosphate trisodium is a modified ribonucleoside 5′-triphosphate. When incorporated into mRNA, 5-Methylcytidine 5′-triphosphate trisodium enhances the translation efficiency and stability of the mRNA, and reduces the innate immune response. 5-Methylcytidine 5′-triphosphate trisodium can be used in studies related to gene replacement and vaccination applications .
Cat. No.: HY-147338S1
Synonyms: 5-Methyl-CTP-15N2, 13C trisodium
Research Areas:
5-Methylcytidine 5′-triphosphate-15N2, 13C (5-Methyl-CTP-15N2, 13C) trisodium is the 15N and 13C labled 5-Methylcytidine 5’-triphosphate (5-Methyl-CTP) trisodium (HY-147338A). 5-Methylcytidine 5’-triphosphate trisodium is a modified ribonucleoside 5′-triphosphate. When incorporated into mRNA, 5-Methylcytidine 5′-triphosphate trisodium enhances the translation efficiency and stability of the mRNA, and reduces the innate immune response. 5-Methylcytidine 5′-triphosphate trisodium can be used in studies related to gene replacement and vaccination applications .
Cat. No.: HY-107845R
CAS No.: 14892-97-8
Research Areas:
SCR7 pyrazine (Standard) is the analytical standard of SCR7 pyrazine (HY-107845). This product is intended for research and analytical applications. SCR7 pyrazine is a DNA ligase IV inhibitor that blocks nonhomologous end-joining (NHEJ) in a ligase IV-dependent manner. SCR7 pyrazine increases the efficiency of Cas9-mediated homology-directed repair (HDR). SCR7 pyrazine induces cell apoptosis and has anticancer activity .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
